(23 nodes) FOXO-mediated transcription of cell cycle genes network (Oryzias melastigma)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC112156730	Myostatin a. (355 aa)
	SMAD3-2	Mothers against decapentaplegic homolog. (429 aa)
	ENSOMEP00000036288	Fork-head domain-containing protein. (518 aa)
	ENSOMEP00000036054	Fork-head domain-containing protein. (337 aa)
	LOC112148478	Mothers against decapentaplegic homolog. (467 aa)
	foxo3	Forkhead box O3b. (661 aa)
	smad2	Mothers against decapentaplegic homolog. (473 aa)
	LOC112155279	Myostatin b. (378 aa)
	gdf11	Growth differentiation factor 11. (388 aa)
	ENSOMEP00000017692	Forkhead box G1a. (348 aa)
	LOC112144034	Forkhead box O6 a. (726 aa)
	LOC112136593	Mothers against decapentaplegic homolog. (536 aa)
	btg1	B-cell translocation gene 1, anti-proliferative. (182 aa)
	LOC112153119	Forkhead box O4. (637 aa)
	ENSOMEP00000032745	MH1 domain-containing protein. (63 aa)
	LOC112148176	Mothers against decapentaplegic homolog. (510 aa)
	LOC112149680	Forkhead box O1 a. (657 aa)
	LOC112141271	Fork-head domain-containing protein. (381 aa)
	CCNG2	Cyclin G2; Belongs to the cyclin family. (331 aa)
	LOC112136562	Forkhead box O6 b. (708 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	ENSOMEP00000023058	Mothers against decapentaplegic homolog. (493 aa)
	ccng2	Cyclin G2; Belongs to the cyclin family. (334 aa)

Your Current Organism:

Oryzias melastigma

NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCNG2	ccng2	ENSOMEP00000009819	ENSOMEP00000023732	Cyclin G2; Belongs to the cyclin family.	Cyclin G2; Belongs to the cyclin family.	0.963
ENSOMEP00000017692	ENSOMEP00000023058	ENSOMEP00000017692	ENSOMEP00000023058	Forkhead box G1a.	Mothers against decapentaplegic homolog.	0.635
ENSOMEP00000017692	ENSOMEP00000032745	ENSOMEP00000017692	ENSOMEP00000032745	Forkhead box G1a.	MH1 domain-containing protein.	0.493
ENSOMEP00000017692	ENSOMEP00000036054	ENSOMEP00000017692	ENSOMEP00000036054	Forkhead box G1a.	Fork-head domain-containing protein.	0.873
ENSOMEP00000017692	ENSOMEP00000036288	ENSOMEP00000017692	ENSOMEP00000036288	Forkhead box G1a.	Fork-head domain-containing protein.	0.601
ENSOMEP00000017692	LOC112136593	ENSOMEP00000017692	ENSOMEP00000023904	Forkhead box G1a.	Mothers against decapentaplegic homolog.	0.635
ENSOMEP00000017692	LOC112141271	ENSOMEP00000017692	ENSOMEP00000011336	Forkhead box G1a.	Fork-head domain-containing protein.	0.873
ENSOMEP00000017692	LOC112148176	ENSOMEP00000017692	ENSOMEP00000021474	Forkhead box G1a.	Mothers against decapentaplegic homolog.	0.635
ENSOMEP00000017692	LOC112148478	ENSOMEP00000017692	ENSOMEP00000034558	Forkhead box G1a.	Mothers against decapentaplegic homolog.	0.493
ENSOMEP00000017692	LOC112149680	ENSOMEP00000017692	ENSOMEP00000022349	Forkhead box G1a.	Forkhead box O1 a.	0.601
ENSOMEP00000017692	LOC112153119	ENSOMEP00000017692	ENSOMEP00000032474	Forkhead box G1a.	Forkhead box O4.	0.601
ENSOMEP00000017692	SMAD3	ENSOMEP00000017692	ENSOMEP00000007833	Forkhead box G1a.	Mothers against decapentaplegic homolog.	0.493
ENSOMEP00000017692	SMAD3-2	ENSOMEP00000017692	ENSOMEP00000018305	Forkhead box G1a.	Mothers against decapentaplegic homolog.	0.493
ENSOMEP00000017692	foxo3	ENSOMEP00000017692	ENSOMEP00000006411	Forkhead box G1a.	Forkhead box O3b.	0.601
ENSOMEP00000017692	smad2	ENSOMEP00000017692	ENSOMEP00000018968	Forkhead box G1a.	Mothers against decapentaplegic homolog.	0.493
ENSOMEP00000023058	ENSOMEP00000017692	ENSOMEP00000023058	ENSOMEP00000017692	Mothers against decapentaplegic homolog.	Forkhead box G1a.	0.635
ENSOMEP00000023058	ENSOMEP00000032745	ENSOMEP00000023058	ENSOMEP00000032745	Mothers against decapentaplegic homolog.	MH1 domain-containing protein.	0.894
ENSOMEP00000023058	ENSOMEP00000036054	ENSOMEP00000023058	ENSOMEP00000036054	Mothers against decapentaplegic homolog.	Fork-head domain-containing protein.	0.635
ENSOMEP00000023058	ENSOMEP00000036288	ENSOMEP00000023058	ENSOMEP00000036288	Mothers against decapentaplegic homolog.	Fork-head domain-containing protein.	0.733
ENSOMEP00000023058	LOC112136593	ENSOMEP00000023058	ENSOMEP00000023904	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.891