(31 nodes) Ubiquinone and other terpenoid-quinone biosynthesis network (Oryzias melastigma)

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Your Input:
	tat	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (475 aa)
	ggcx	Gamma-glutamyl carboxylase. (763 aa)
	ENSOMEP00000024011	Si:ch73-390p7.2. (125 aa)
	abhd8	Abhydrolase domain containing 8b. (472 aa)
	LOC112147184	Abhydrolase domain containing 8a. (474 aa)
	LOC112154808	Flavodoxin_2 domain-containing protein. (271 aa)
	ENSOMEP00000026130	VOC domain-containing protein. (245 aa)
	abhd11	Abhydrolase domain containing 11. (307 aa)
	ENSOMEP00000027124	Vitamin K epoxide reductase complex, subunit 1-like 1. (204 aa)
	coq7	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. (218 aa)
	gins4	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
	coq5	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (343 aa)
	LOC112148495	4-hydroxyphenylpyruvate dioxygenase. (393 aa)
	med24	Mediator complex subunit 24. (985 aa)
	coq6	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (510 aa)
	coq2	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (375 aa)
	ubiad1	UbiA prenyltransferase domain containing 1. (348 aa)
	ENSOMEP00000003067	Cell division cycle and apoptosis regulator 1. (1245 aa)
	coq3	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (329 aa)
	itprip	Inositol 1,4,5-trisphosphate receptor interacting protein. (533 aa)
	LOC112154838	Flavodoxin_2 domain-containing protein. (295 aa)
	ENSOMEP00000007157	Uncharacterized protein. (327 aa)
	ENSOMEP00000008005	VOC domain-containing protein. (127 aa)
	ENSOMEP00000008781	Transmembrane protein 94. (1297 aa)
	ENSOMEP00000009575	Si:dkeyp-80c12.4. (631 aa)
	hpdl	4-hydroxyphenylpyruvate dioxygenase. (444 aa)
	acot13	Acyl-CoA thioesterase 13. (142 aa)
	LOC112155852	Procollagen C-endopeptidase enhancer b. (612 aa)
	ENSOMEP00000011317	Uncharacterized protein. (270 aa)
	LOC112157998	Zinc finger protein 410. (531 aa)
	LOC112154204	Vitamin K epoxide reductase complex, subunit 1. (167 aa)

Your Current Organism:

Oryzias melastigma

NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSOMEP00000003067	ENSOMEP00000007157	ENSOMEP00000003067	ENSOMEP00000007157	Cell division cycle and apoptosis regulator 1.	Uncharacterized protein.	0.741
ENSOMEP00000003067	ENSOMEP00000008005	ENSOMEP00000003067	ENSOMEP00000008005	Cell division cycle and apoptosis regulator 1.	VOC domain-containing protein.	0.748
ENSOMEP00000003067	ENSOMEP00000011317	ENSOMEP00000003067	ENSOMEP00000011317	Cell division cycle and apoptosis regulator 1.	Uncharacterized protein.	0.741
ENSOMEP00000003067	ENSOMEP00000026130	ENSOMEP00000003067	ENSOMEP00000026130	Cell division cycle and apoptosis regulator 1.	VOC domain-containing protein.	0.748
ENSOMEP00000003067	LOC112148495	ENSOMEP00000003067	ENSOMEP00000029530	Cell division cycle and apoptosis regulator 1.	4-hydroxyphenylpyruvate dioxygenase.	0.748
ENSOMEP00000003067	coq5	ENSOMEP00000003067	ENSOMEP00000029092	Cell division cycle and apoptosis regulator 1.	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2).	0.741
ENSOMEP00000003067	hpdl	ENSOMEP00000003067	ENSOMEP00000009750	Cell division cycle and apoptosis regulator 1.	4-hydroxyphenylpyruvate dioxygenase.	0.748
ENSOMEP00000007157	ENSOMEP00000003067	ENSOMEP00000007157	ENSOMEP00000003067	Uncharacterized protein.	Cell division cycle and apoptosis regulator 1.	0.741
ENSOMEP00000007157	ENSOMEP00000009575	ENSOMEP00000007157	ENSOMEP00000009575	Uncharacterized protein.	Si:dkeyp-80c12.4.	0.736
ENSOMEP00000007157	ENSOMEP00000027124	ENSOMEP00000007157	ENSOMEP00000027124	Uncharacterized protein.	Vitamin K epoxide reductase complex, subunit 1-like 1.	0.590
ENSOMEP00000007157	LOC112154204	ENSOMEP00000007157	ENSOMEP00000017750	Uncharacterized protein.	Vitamin K epoxide reductase complex, subunit 1.	0.674
ENSOMEP00000007157	coq2	ENSOMEP00000007157	ENSOMEP00000029736	Uncharacterized protein.	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	0.824
ENSOMEP00000007157	coq3	ENSOMEP00000007157	ENSOMEP00000004678	Uncharacterized protein.	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	0.737
ENSOMEP00000007157	coq6	ENSOMEP00000007157	ENSOMEP00000034988	Uncharacterized protein.	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	0.939
ENSOMEP00000007157	coq7	ENSOMEP00000007157	ENSOMEP00000027508	Uncharacterized protein.	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner.	0.935
ENSOMEP00000007157	itprip	ENSOMEP00000007157	ENSOMEP00000005357	Uncharacterized protein.	Inositol 1,4,5-trisphosphate receptor interacting protein.	0.736
ENSOMEP00000007157	ubiad1	ENSOMEP00000007157	ENSOMEP00000001519	Uncharacterized protein.	UbiA prenyltransferase domain containing 1.	0.781
ENSOMEP00000008005	ENSOMEP00000003067	ENSOMEP00000008005	ENSOMEP00000003067	VOC domain-containing protein.	Cell division cycle and apoptosis regulator 1.	0.748
ENSOMEP00000008005	ENSOMEP00000026130	ENSOMEP00000008005	ENSOMEP00000026130	VOC domain-containing protein.	VOC domain-containing protein.	0.888
ENSOMEP00000008005	LOC112148495	ENSOMEP00000008005	ENSOMEP00000029530	VOC domain-containing protein.	4-hydroxyphenylpyruvate dioxygenase.	0.876