(78 nodes) Pyruvate metabolism network (Oryzias melastigma)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSOMEP00000035295	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (891 aa)
	LOC112143239	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (924 aa)
	LOC112140226	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (435 aa)
	LOC112140203	Uncharacterized protein. (621 aa)
	dlat	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (639 aa)
	LOC112158967	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (457 aa)
	LOC112151791	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
	LOC112149431	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (463 aa)
	aldh16a1	Aldehyde dehydrogenase 16 family, member A1. (792 aa)
	ENSOMEP00000031390	Malate dehydrogenase. (209 aa)
	LOC112154983	PNKD metallo-beta-lactamase domain containing. (359 aa)
	parp6	Poly [ADP-ribose] polymerase. (642 aa)
	LOC112140371	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
	LOC112152743	Pyruvate kinase; Belongs to the pyruvate kinase family. (597 aa)
	ENSOMEP00000030077	Poly (ADP-ribose) polymerase family, member 6b. (516 aa)
	ENSOMEP00000030070	Si:ch211-257p13.3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (466 aa)
	ENSOMEP00000030036	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (226 aa)
	clptm1	CLPTM1 regulator of GABA type A receptor forward trafficking. (628 aa)
	LOC112157059	Glyoxylate reductase/hydroxypyruvate reductase b; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (359 aa)
	ENSOMEP00000028984	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (330 aa)
	HAGHL	Hydroxyacylglutathione hydrolase like. (282 aa)
	LOC112144045	Uncharacterized protein. (527 aa)
	ENSOMEP00000028394	Malate synthase-like. (331 aa)
	ENSOMEP00000028226	Si:ch73-71c20.5. (140 aa)
	ldhd	Lactate dehydrogenase D. (502 aa)
	LOC112147259	Aldehyde dehydrogenase 9 family, member A1b; Belongs to the aldehyde dehydrogenase family. (518 aa)
	LOC112143273	Pyruvate kinase; Belongs to the pyruvate kinase family. (543 aa)
	acss2	Acyl-CoA synthetase short chain family member 2. (698 aa)
	ENSOMEP00000025391	Acetyl-CoA carboxylase alpha. (2331 aa)
	ENSOMEP00000024302	BBS1 domain-containing protein. (391 aa)
	pdhb	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (374 aa)
	LOC112144281	Uncharacterized protein. (634 aa)
	acat1	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (418 aa)
	LOC112150670	Aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 1; Belongs to the aldehyde dehydrogenase family. (505 aa)
	ENSOMEP00000021899	Acylphosphatase 2, muscle type; Belongs to the acylphosphatase family. (96 aa)
	LOC112161617	Malate dehydrogenase. (333 aa)
	me2	Malic enzyme. (608 aa)
	acss1	Acetyl-coenzyme A synthetase. (680 aa)
	aldh2	Aldehyde dehydrogenase 2 family member, tandem duplicate 2; Belongs to the aldehyde dehydrogenase family. (520 aa)
	ACYP1	Acylphosphatase. (129 aa)
	LOC112151857	Acetyl-coenzyme A synthetase. (673 aa)
	ttll12	Tubulin tyrosine ligase-like family, member 12. (619 aa)
	mdh1	Malate dehydrogenase. (350 aa)
	GLO1	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (179 aa)
	LACTB2	Lactamase beta 2. (287 aa)
	ENSOMEP00000015791	Uncharacterized protein. (122 aa)
	pck2	Phosphoenolpyruvate carboxykinase 2 (mitochondrial). (633 aa)
	LOC112150832	Cocaine- and amphetamine-regulated transcript 1. (107 aa)
	ENSOMEP00000013754	Pyruvate kinase; Belongs to the pyruvate kinase family. (554 aa)
	slc25a3	Solute carrier family 25 member 3a; Belongs to the mitochondrial carrier (TC 2.A.29) family. (357 aa)
	tmem104	Transmembrane protein 104. (491 aa)
	aldh7a1	Aldehyde dehydrogenase 7 family, member A1; Belongs to the aldehyde dehydrogenase family. (563 aa)
	ENSOMEP00000012701	Uncharacterized protein. (100 aa)
	LOC112162207	Zgc:136493. (517 aa)
	ENSOMEP00000011472	Dihydrolipoyl dehydrogenase. (508 aa)
	ENSOMEP00000011152	Family with sequence similarity 114 member A1. (652 aa)
	hagh	Hydroxyacylglutathione hydrolase. (338 aa)
	clptm1l	CLPTM1 like. (580 aa)
	LOC112146482	Uncharacterized protein. (107 aa)
	LOC112152922	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (358 aa)
	LOC112154846	Malic enzyme. (613 aa)
	ENSOMEP00000008966	Malic_M domain-containing protein. (234 aa)
	fh	Fumarate hydratase. (499 aa)
	ENSOMEP00000007240	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (507 aa)
	LOC112142944	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (489 aa)
	pc	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1179 aa)
	mdh1b	Malate dehydrogenase 1B, NAD (soluble). (460 aa)
	acat2	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
	me1	Malic enzyme. (588 aa)
	acot11	Acyl-CoA thioesterase 11b. (584 aa)
	bbs1	Bardet-Biedl syndrome 1. (582 aa)
	tsr1	TSR1 ribosome maturation factor. (833 aa)
	LOC112153810	Glyoxylate reductase/hydroxypyruvate reductase a; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (328 aa)
	ENSOMEP00000003292	Glyoxalase domain containing 4. (338 aa)
	ENSOMEP00000001870	Uncharacterized protein. (161 aa)
	acacb	Acetyl-CoA carboxylase beta. (2423 aa)
	kifc1	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (628 aa)
	pck1	Phosphoenolpyruvate carboxykinase 1 (soluble). (624 aa)

Your Current Organism:

Oryzias melastigma

NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACYP1	ENSOMEP00000007240	ENSOMEP00000019273	ENSOMEP00000007240	Acylphosphatase.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.893
ACYP1	ENSOMEP00000021899	ENSOMEP00000019273	ENSOMEP00000021899	Acylphosphatase.	Acylphosphatase 2, muscle type; Belongs to the acylphosphatase family.	0.890
ACYP1	LOC112142944	ENSOMEP00000019273	ENSOMEP00000007084	Acylphosphatase.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.892
ACYP1	LOC112144281	ENSOMEP00000019273	ENSOMEP00000023248	Acylphosphatase.	Uncharacterized protein.	0.672
ACYP1	acot11	ENSOMEP00000019273	ENSOMEP00000004449	Acylphosphatase.	Acyl-CoA thioesterase 11b.	0.672
ACYP1	aldh7a1	ENSOMEP00000019273	ENSOMEP00000012765	Acylphosphatase.	Aldehyde dehydrogenase 7 family, member A1; Belongs to the aldehyde dehydrogenase family.	0.925
ENSOMEP00000001870	ENSOMEP00000007240	ENSOMEP00000001870	ENSOMEP00000007240	Uncharacterized protein.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.596
ENSOMEP00000001870	ENSOMEP00000008966	ENSOMEP00000001870	ENSOMEP00000008966	Uncharacterized protein.	Malic_M domain-containing protein.	0.645
ENSOMEP00000001870	ENSOMEP00000025391	ENSOMEP00000001870	ENSOMEP00000025391	Uncharacterized protein.	Acetyl-CoA carboxylase alpha.	0.707
ENSOMEP00000001870	ENSOMEP00000028394	ENSOMEP00000001870	ENSOMEP00000028394	Uncharacterized protein.	Malate synthase-like.	0.812
ENSOMEP00000001870	LOC112142944	ENSOMEP00000001870	ENSOMEP00000007084	Uncharacterized protein.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.596
ENSOMEP00000001870	LOC112144281	ENSOMEP00000001870	ENSOMEP00000023248	Uncharacterized protein.	Uncharacterized protein.	0.681
ENSOMEP00000001870	LOC112147259	ENSOMEP00000001870	ENSOMEP00000027368	Uncharacterized protein.	Aldehyde dehydrogenase 9 family, member A1b; Belongs to the aldehyde dehydrogenase family.	0.603
ENSOMEP00000001870	LOC112150670	ENSOMEP00000001870	ENSOMEP00000022180	Uncharacterized protein.	Aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 1; Belongs to the aldehyde dehydrogenase family.	0.603
ENSOMEP00000001870	LOC112151857	ENSOMEP00000001870	ENSOMEP00000019262	Uncharacterized protein.	Acetyl-coenzyme A synthetase.	0.754
ENSOMEP00000001870	LOC112154846	ENSOMEP00000001870	ENSOMEP00000009032	Uncharacterized protein.	Malic enzyme.	0.645
ENSOMEP00000001870	acacb	ENSOMEP00000001870	ENSOMEP00000001815	Uncharacterized protein.	Acetyl-CoA carboxylase beta.	0.707
ENSOMEP00000001870	acot11	ENSOMEP00000001870	ENSOMEP00000004449	Uncharacterized protein.	Acyl-CoA thioesterase 11b.	0.681
ENSOMEP00000001870	acss1	ENSOMEP00000001870	ENSOMEP00000019808	Uncharacterized protein.	Acetyl-coenzyme A synthetase.	0.754
ENSOMEP00000001870	acss2	ENSOMEP00000001870	ENSOMEP00000026201	Uncharacterized protein.	Acyl-CoA synthetase short chain family member 2.	0.754