(71 nodes) Glyoxylate and dicarboxylate metabolism network (Oryzias melastigma)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ENSOMEP00000028394	Malate synthase-like. (331 aa)
	hoga1	4-hydroxy-2-oxoglutarate aldolase 1; Belongs to the DapA family. (327 aa)
	ENSOMEP00000028984	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (330 aa)
	LOC112155910	Patatin-like phospholipase domain containing 8. (716 aa)
	LOC112157059	Glyoxylate reductase/hydroxypyruvate reductase b; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (359 aa)
	gldc	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1032 aa)
	ENSOMEP00000030607	Glutamate-ammonia ligase (glutamine synthase) c; Belongs to the glutamine synthetase family. (273 aa)
	ENSOMEP00000030758	Hydroxyacid oxidase (glycolate oxidase) 1. (380 aa)
	atad1	ATPase family AAA domain containing 1b; Belongs to the AAA ATPase family. (362 aa)
	ENSOMEP00000031390	Malate dehydrogenase. (209 aa)
	ENSOMEP00000031436	Nipsnap homolog 2. (303 aa)
	ENSOMEP00000032546	Serine hydroxymethyltransferase 2 (mitochondrial). (500 aa)
	mcee	Methylmalonyl CoA epimerase. (173 aa)
	ENSOMEP00000033026	SOGA family member 3b. (467 aa)
	setd3	Protein-histidine N-methyltransferase. (604 aa)
	ENSOMEP00000034591	Citrate synthase; Belongs to the citrate synthase family. (471 aa)
	ENSOMEP00000034417	Gln_synt_b-grasp domain-containing protein; Belongs to the glutamine synthetase family. (191 aa)
	glyctk	Glycerate kinase. (565 aa)
	ENSOMEP00000001870	Uncharacterized protein. (161 aa)
	ENSOMEP00000001887	Uncharacterized protein. (158 aa)
	glul	Glutamine synthetase. (371 aa)
	LOC112153810	Glyoxylate reductase/hydroxypyruvate reductase a; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (328 aa)
	ireb2	Iron-responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family. (986 aa)
	ENSOMEP00000005506	Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family. (306 aa)
	acat2	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
	LOC112152709	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (175 aa)
	mdh1b	Malate dehydrogenase 1B, NAD (soluble). (460 aa)
	pgp	Phosphoglycolate phosphatase; Belongs to the HAD-like hydrolase superfamily. (307 aa)
	ENSOMEP00000006255	Aminomethyltransferase. (244 aa)
	SOGA1	Suppressor of glucose, autophagy associated 1. (1844 aa)
	LOC112142927	NIPSNAP domain-containing protein. (276 aa)
	ENSOMEP00000008086	Uncharacterized protein. (317 aa)
	LOC112158687	Uncharacterized protein. (264 aa)
	LOC112153212	Nipsnap homolog 3A (C. elegans). (249 aa)
	LOC112152144	PNPLA domain-containing protein. (876 aa)
	lgsn	Lengsin, lens protein with glutamine synthetase domain; Belongs to the glutamine synthetase family. (656 aa)
	wdtc1	WD and tetratricopeptide repeats 1. (696 aa)
	LOC112146482	Uncharacterized protein. (107 aa)
	LOC112148509	Nipsnap homolog 1 (C. elegans). (290 aa)
	afmid	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (322 aa)
	ENSOMEP00000011472	Dihydrolipoyl dehydrogenase. (508 aa)
	LOC112162207	Zgc:136493. (517 aa)
	ankrd1	Ankyrin repeat domain 1a (cardiac muscle). (307 aa)
	LOC112150832	Cocaine- and amphetamine-regulated transcript 1. (107 aa)
	LOC112143344	SOGA family member 3a. (829 aa)
	ENSOMEP00000014606	DUF4482 domain-containing protein. (893 aa)
	pccb	Propionyl-CoA carboxylase subunit beta. (560 aa)
	hao2	Hydroxyacid oxidase 2 (long chain). (370 aa)
	ENSOMEP00000015791	Uncharacterized protein. (122 aa)
	LOC112148610	ATPase family AAA domain containing 1a; Belongs to the AAA ATPase family. (378 aa)
	mdh1	Malate dehydrogenase. (350 aa)
	pxdn	Peroxidasin. (1473 aa)
	ENSOMEP00000018666	Methylmalonyl CoA mutase. (650 aa)
	LOC112151857	Acetyl-coenzyme A synthetase. (673 aa)
	acss1	Acetyl-coenzyme A synthetase. (680 aa)
	LOC112161617	Malate dehydrogenase. (333 aa)
	LOC112147379	Serine--pyruvate aminotransferase. (430 aa)
	acat1	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (418 aa)
	LOC112160869	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (174 aa)
	setd4	Uncharacterized protein. (437 aa)
	pcca	Propionyl-CoA carboxylase subunit alpha. (713 aa)
	cat	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
	LOC112159311	PNPLA domain-containing protein. (761 aa)
	shmt1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (482 aa)
	LOC112159621	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (552 aa)
	aco1	Aconitase 1, soluble; Belongs to the aconitase/IPM isomerase family. (892 aa)
	acss2	Acyl-CoA synthetase short chain family member 2. (698 aa)
	ENSOMEP00000026368	Microtubule crosslinking factor 1. (489 aa)
	ENSOMEP00000026375	Uncharacterized protein. (155 aa)
	aco2	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (781 aa)
	ENSOMEP00000027808	Serine--pyruvate aminotransferase. (337 aa)

Your Current Organism:

Oryzias melastigma

NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSOMEP00000001870	ENSOMEP00000028394	ENSOMEP00000001870	ENSOMEP00000028394	Uncharacterized protein.	Malate synthase-like.	0.812
ENSOMEP00000001870	ENSOMEP00000030758	ENSOMEP00000001870	ENSOMEP00000030758	Uncharacterized protein.	Hydroxyacid oxidase (glycolate oxidase) 1.	0.536
ENSOMEP00000001870	ENSOMEP00000034591	ENSOMEP00000001870	ENSOMEP00000034591	Uncharacterized protein.	Citrate synthase; Belongs to the citrate synthase family.	0.861
ENSOMEP00000001870	LOC112151857	ENSOMEP00000001870	ENSOMEP00000019262	Uncharacterized protein.	Acetyl-coenzyme A synthetase.	0.754
ENSOMEP00000001870	aco1	ENSOMEP00000001870	ENSOMEP00000026015	Uncharacterized protein.	Aconitase 1, soluble; Belongs to the aconitase/IPM isomerase family.	0.418
ENSOMEP00000001870	aco2	ENSOMEP00000001870	ENSOMEP00000026609	Uncharacterized protein.	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	0.418
ENSOMEP00000001870	acss1	ENSOMEP00000001870	ENSOMEP00000019808	Uncharacterized protein.	Acetyl-coenzyme A synthetase.	0.754
ENSOMEP00000001870	acss2	ENSOMEP00000001870	ENSOMEP00000026201	Uncharacterized protein.	Acyl-CoA synthetase short chain family member 2.	0.754
ENSOMEP00000001870	hao2	ENSOMEP00000001870	ENSOMEP00000015427	Uncharacterized protein.	Hydroxyacid oxidase 2 (long chain).	0.536
ENSOMEP00000001870	ireb2	ENSOMEP00000001870	ENSOMEP00000004149	Uncharacterized protein.	Iron-responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family.	0.418
ENSOMEP00000001870	pcca	ENSOMEP00000001870	ENSOMEP00000022381	Uncharacterized protein.	Propionyl-CoA carboxylase subunit alpha.	0.695
ENSOMEP00000001870	pccb	ENSOMEP00000001870	ENSOMEP00000014642	Uncharacterized protein.	Propionyl-CoA carboxylase subunit beta.	0.686
ENSOMEP00000001887	ENSOMEP00000026368	ENSOMEP00000001887	ENSOMEP00000026368	Uncharacterized protein.	Microtubule crosslinking factor 1.	0.887
ENSOMEP00000005506	ENSOMEP00000027808	ENSOMEP00000005506	ENSOMEP00000027808	Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family.	Serine--pyruvate aminotransferase.	0.892
ENSOMEP00000005506	ENSOMEP00000028394	ENSOMEP00000005506	ENSOMEP00000028394	Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family.	Malate synthase-like.	0.538
ENSOMEP00000005506	ENSOMEP00000028984	ENSOMEP00000005506	ENSOMEP00000028984	Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family.	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.768
ENSOMEP00000005506	LOC112147379	ENSOMEP00000005506	ENSOMEP00000021723	Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family.	Serine--pyruvate aminotransferase.	0.892
ENSOMEP00000005506	LOC112153810	ENSOMEP00000005506	ENSOMEP00000003349	Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family.	Glyoxylate reductase/hydroxypyruvate reductase a; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.918
ENSOMEP00000005506	LOC112157059	ENSOMEP00000005506	ENSOMEP00000029514	Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family.	Glyoxylate reductase/hydroxypyruvate reductase b; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.918
ENSOMEP00000005506	LOC112162207	ENSOMEP00000005506	ENSOMEP00000012066	Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family.	Zgc:136493.	0.768