(23 nodes) 2-Oxocarboxylic acid metabolism network (Oryzias melastigma)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

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co-expression

protein homology

Your Input:
	ENSOMEP00000013721	Aminotran_1_2 domain-containing protein. (438 aa)
	ENSOMEP00000024638	Aminotran_1_2 domain-containing protein. (524 aa)
	acy1	Aminoacylase 1. (419 aa)
	aco1	Aconitase 1, soluble; Belongs to the aconitase/IPM isomerase family. (892 aa)
	aco2	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (781 aa)
	ppp1r16a	Si:ch211-217a12.1. (1028 aa)
	ENSOMEP00000034591	Citrate synthase; Belongs to the citrate synthase family. (471 aa)
	LOC112152846	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
	GOT1	Aspartate aminotransferase. (410 aa)
	idh1	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
	LOC112147363	Glutamic pyruvate transaminase (alanine aminotransferase) 2, like. (515 aa)
	ireb2	Iron-responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family. (986 aa)
	got1	Aspartate aminotransferase. (441 aa)
	LOC112146039	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (389 aa)
	hsd17b14	Hydroxysteroid (17-beta) dehydrogenase 14; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (285 aa)
	idh3g	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (392 aa)
	ENSOMEP00000019982	N-acetylglutamate synthase. (455 aa)
	idh3a	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (368 aa)
	got2	Aspartate aminotransferase. (428 aa)
	idh3b	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (390 aa)
	aadat	Aminoadipate aminotransferase. (425 aa)
	IDH2	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
	ENSOMEP00000012622	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (385 aa)

Your Current Organism:

Oryzias melastigma

NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSOMEP00000012622	ENSOMEP00000013721	ENSOMEP00000012622	ENSOMEP00000013721	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	Aminotran_1_2 domain-containing protein.	0.788
ENSOMEP00000012622	ENSOMEP00000019982	ENSOMEP00000012622	ENSOMEP00000019982	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	N-acetylglutamate synthase.	0.461
ENSOMEP00000012622	ENSOMEP00000024638	ENSOMEP00000012622	ENSOMEP00000024638	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	Aminotran_1_2 domain-containing protein.	0.788
ENSOMEP00000012622	ENSOMEP00000034591	ENSOMEP00000012622	ENSOMEP00000034591	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	Citrate synthase; Belongs to the citrate synthase family.	0.855
ENSOMEP00000012622	GOT1	ENSOMEP00000012622	ENSOMEP00000010261	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	Aspartate aminotransferase.	0.744
ENSOMEP00000012622	IDH2	ENSOMEP00000012622	ENSOMEP00000011892	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.886
ENSOMEP00000012622	LOC112146039	ENSOMEP00000012622	ENSOMEP00000016243	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.663
ENSOMEP00000012622	LOC112147363	ENSOMEP00000012622	ENSOMEP00000008392	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	Glutamic pyruvate transaminase (alanine aminotransferase) 2, like.	0.788
ENSOMEP00000012622	LOC112152846	ENSOMEP00000012622	ENSOMEP00000036075	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.886
ENSOMEP00000012622	aadat	ENSOMEP00000012622	ENSOMEP00000015081	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	Aminoadipate aminotransferase.	0.761
ENSOMEP00000012622	aco1	ENSOMEP00000012622	ENSOMEP00000026015	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	Aconitase 1, soluble; Belongs to the aconitase/IPM isomerase family.	0.850
ENSOMEP00000012622	aco2	ENSOMEP00000012622	ENSOMEP00000026609	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	0.953
ENSOMEP00000012622	got1	ENSOMEP00000012622	ENSOMEP00000002354	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	Aspartate aminotransferase.	0.744
ENSOMEP00000012622	got2	ENSOMEP00000012622	ENSOMEP00000022801	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	Aspartate aminotransferase.	0.854
ENSOMEP00000012622	idh1	ENSOMEP00000012622	ENSOMEP00000009945	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.922
ENSOMEP00000012622	idh3a	ENSOMEP00000012622	ENSOMEP00000020850	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.998
ENSOMEP00000012622	idh3b	ENSOMEP00000012622	ENSOMEP00000022973	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.853
ENSOMEP00000012622	ireb2	ENSOMEP00000012622	ENSOMEP00000004149	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	Iron-responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family.	0.850
ENSOMEP00000012622	ppp1r16a	ENSOMEP00000012622	ENSOMEP00000029343	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	Si:ch211-217a12.1.	0.788
ENSOMEP00000013721	ENSOMEP00000012622	ENSOMEP00000013721	ENSOMEP00000012622	Aminotran_1_2 domain-containing protein.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.788