STRINGSTRING
rtel1 rtel1 PTGDR2 PTGDR2 ENSOMEP00000003330 ENSOMEP00000003330 rpa1 rpa1 HES2 HES2 tent2 tent2 top3a top3a polk polk ENSOMEP00000004644 ENSOMEP00000004644 FAAP100 FAAP100 LOC112136477 LOC112136477 atrip atrip ENSOMEP00000007258 ENSOMEP00000007258 LOC112136804 LOC112136804 RPA1 RPA1 fanci fanci rev1 rev1 polq polq LOC112162145 LOC112162145 ENSOMEP00000012865 ENSOMEP00000012865 ENSOMEP00000013247 ENSOMEP00000013247 fan1 fan1 LOC112144436 LOC112144436 LOC112141146 LOC112141146 telo2 telo2 LOC112158704 LOC112158704 eme2 eme2 palb2 palb2 fance fance ENSOMEP00000018901 ENSOMEP00000018901 ENSOMEP00000018923 ENSOMEP00000018923 hes1 hes1 ENSOMEP00000020292 ENSOMEP00000020292 ENSOMEP00000020693 ENSOMEP00000020693 ENSOMEP00000002422 ENSOMEP00000002422 rmi2 rmi2 mical2 mical2 rad51 rad51 LOC112157806 LOC112157806 FANCG FANCG LOC112156448 LOC112156448 slx4 slx4 ENSOMEP00000025223 ENSOMEP00000025223 fancb fancb rpa3 rpa3 ercc4 ercc4 cenpx cenpx fancm fancm ENSOMEP00000028071 ENSOMEP00000028071 poli poli rev3l rev3l ENSOMEP00000028431 ENSOMEP00000028431 ENSOMEP00000028578 ENSOMEP00000028578 n4bp2 n4bp2 wdr48 wdr48 nutf2 nutf2 poln poln ENSOMEP00000031192 ENSOMEP00000031192 fancf fancf mlh1 mlh1 pithd1 pithd1 rpa2 rpa2 eme1 eme1 faap24 faap24 hes4 hes4 ENSOMEP00000035332 ENSOMEP00000035332 ENSOMEP00000035339 ENSOMEP00000035339 ENSOMEP00000035350 ENSOMEP00000035350 CNP CNP blm blm rmi1 rmi1 fancl fancl ercc1 ercc1 LOC112149564 LOC112149564 top3b top3b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rtel1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1174 aa)
PTGDR2Prostaglandin D2 receptor 2; Belongs to the G-protein coupled receptor 1 family. (367 aa)
ENSOMEP00000003330RING-type domain-containing protein. (841 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (598 aa)
HES2Hes family bHLH transcription factor 2, tandem duplicate 1. (201 aa)
tent2Terminal nucleotidyltransferase 2. (483 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1024 aa)
polkPolymerase (DNA directed) kappa. (847 aa)
ENSOMEP00000004644Polymerase (DNA directed), eta. (302 aa)
FAAP100Uncharacterized protein. (827 aa)
LOC112136477Hairy-related 8.2. (182 aa)
atripUncharacterized protein. (739 aa)
ENSOMEP00000007258Ubiquitin carboxyl-terminal hydrolase. (784 aa)
LOC112136804SAS-6 centriolar assembly protein. (581 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (649 aa)
fanciFA complementation group I. (1323 aa)
rev1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1347 aa)
polqPolymerase (DNA directed), theta. (2616 aa)
LOC112162145NTF2 domain-containing protein. (129 aa)
ENSOMEP00000012865Uncharacterized protein. (281 aa)
ENSOMEP00000013247Ubiquitin-conjugating enzyme E2T (putative). (186 aa)
fan1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (940 aa)
LOC112144436Uncharacterized protein. (225 aa)
LOC112141146Microtubule associated monooxygenase, calponin and LIM domain containing 2b. (1375 aa)
telo2TEL2, telomere maintenance 2, homolog (S. cerevisiae). (823 aa)
LOC112158704Microtubule associated monooxygenase, calponin and LIM domain containing 1. (1273 aa)
eme2ERCC4 domain-containing protein. (429 aa)
palb2PALB2_WD40 domain-containing protein. (1266 aa)
fanceFA complementation group E. (524 aa)
ENSOMEP00000018901FAD_binding_3 domain-containing protein. (324 aa)
ENSOMEP00000018923LIM zinc-binding domain-containing protein. (79 aa)
hes1Hairy-related 6. (274 aa)
ENSOMEP00000020292FA complementation group C. (591 aa)
ENSOMEP00000020693FAD_binding_3 domain-containing protein. (292 aa)
ENSOMEP00000002422MUS81 structure-specific endonuclease subunit. (514 aa)
rmi2RecQ mediated genome instability 2. (140 aa)
mical2Microtubule associated monooxygenase, calponin and LIM domain containing 2a. (978 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa)
LOC112157806G_PROTEIN_RECEP_F1_2 domain-containing protein. (427 aa)
FANCGFA complementation group G. (607 aa)
LOC112156448Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (276 aa)
slx4SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1506 aa)
ENSOMEP00000025223PMS1 homolog 2, mismatch repair system component. (805 aa)
fancbFA complementation group B. (857 aa)
rpa3Replication protein A3. (122 aa)
ercc4Excision repair cross-complementation group 4. (917 aa)
cenpxCentromere protein X. (106 aa)
fancmUncharacterized protein. (1898 aa)
ENSOMEP00000028071BRCA1 interacting protein C-terminal helicase 1. (1312 aa)
poliPolymerase (DNA directed) iota. (714 aa)
rev3lREV3 like, DNA directed polymerase zeta catalytic subunit. (2959 aa)
ENSOMEP00000028431RAD51 paralog C. (307 aa)
ENSOMEP00000028578FA complementation group D2. (1400 aa)
n4bp2NEDD4 binding protein 2. (1711 aa)
wdr48WD repeat domain 48b. (677 aa)
nutf2Nuclear transport factor 2. (127 aa)
polnPolymerase (DNA directed) nu. (1171 aa)
ENSOMEP00000031192Uncharacterized protein. (116 aa)
fancfFA complementation group F. (344 aa)
mlh1MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (728 aa)
pithd1PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1. (209 aa)
rpa2Replication protein A2. (270 aa)
eme1Essential meiotic structure-specific endonuclease 1. (498 aa)
faap24FA core complex associated protein 24. (209 aa)
hes4Hairy-related 9. (291 aa)
ENSOMEP00000035332BMERB domain-containing protein. (116 aa)
ENSOMEP00000035339LIM zinc-binding domain-containing protein. (73 aa)
ENSOMEP00000035350Calponin-homology (CH) domain-containing protein. (186 aa)
CNP2',3'-cyclic nucleotide 3' phosphodiesterase. (628 aa)
blmBLM RecQ like helicase. (1368 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (647 aa)
fanclFA complementation group L. (378 aa)
ercc1Excision repair cross-complementation group 1. (403 aa)
LOC112149564BRCA2 DNA repair associated. (2893 aa)
top3bDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (859 aa)
Your Current Organism:
Oryzias melastigma
NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka
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