(149 nodes) Oocyte meiosis network (Oryzias melastigma)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ppp2ca	Serine/threonine-protein phosphatase. (309 aa)
	mad2l1	MAD2 mitotic arrest deficient-like 1 (yeast). (202 aa)
	LOC112147429	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1153 aa)
	LOC112142690	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (104 aa)
	ENSOMEP00000024440	Cytoplasmic polyadenylation element binding protein 2. (761 aa)
	rbx1	Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
	LOC112155937	Cysteine three histidine 1. (337 aa)
	ppp2r5e	Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (481 aa)
	CPEB4	Cytoplasmic polyadenylation element binding protein 4. (750 aa)
	cul1	Cullin 1b; Belongs to the cullin family. (777 aa)
	ENSOMEP00000025329	STE20-like kinase a. (950 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (532 aa)
	LOC112138526	Transmembrane protein 82. (337 aa)
	calml4	Calmodulin-like 4a. (153 aa)
	LOC112158536	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1187 aa)
	ywhaq	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b; Belongs to the 14-3-3 family. (249 aa)
	ENSOMEP00000026532	Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (571 aa)
	ppp2cb	Serine/threonine-protein phosphatase. (309 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1419 aa)
	ENSOMEP00000027649	V-mos Moloney murine sarcoma viral oncogene homolog; Belongs to the protein kinase superfamily. (262 aa)
	ppp2r5c	Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (607 aa)
	LOC112163241	Shugoshin_C domain-containing protein. (645 aa)
	ENSOMEP00000029103	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (498 aa)
	LOC112153519	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	PLCZ1	Phosphoinositide phospholipase C. (516 aa)
	ENSOMEP00000029714	Protein kinase domain-containing protein. (102 aa)
	LOC112162254	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; Belongs to the 14-3-3 family. (248 aa)
	calm2-3	Calmodulin 3. (149 aa)
	cdc16	Cell division cycle 16 homolog (S. cerevisiae). (618 aa)
	anapc2	Anaphase promoting complex subunit 2; Belongs to the cullin family. (806 aa)
	ENSOMEP00000031347	Aurora kinase B; Belongs to the protein kinase superfamily. (312 aa)
	adcy7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1099 aa)
	ENSOMEP00000031513	ANAPC4_WD40 domain-containing protein. (206 aa)
	adcy5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1196 aa)
	anapc5	Anaphase promoting complex subunit 5. (773 aa)
	ENSOMEP00000032467	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (539 aa)
	smc1a	Structural maintenance of chromosomes protein. (1231 aa)
	ENSOMEP00000032569	Adenylate cyclase 3b; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (357 aa)
	prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
	ENSOMEP00000032690	Cytoplasmic polyadenylation element binding protein 3. (681 aa)
	ENSOMEP00000032841	Tyrosine-protein kinase receptor. (1405 aa)
	LOC112159026	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1179 aa)
	LOC112156435	Uncharacterized protein. (1276 aa)
	cdc20	Cell division cycle 20 homolog. (556 aa)
	ppp2r5a	Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (508 aa)
	ENSOMEP00000035932	Mitogen-activated protein kinase. (351 aa)
	ppp3r1	Uncharacterized protein. (170 aa)
	cdk2	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
	cdc23	CDC23 (cell division cycle 23, yeast, homolog). (642 aa)
	ENSOMEP00000034970	Anaphase promoting complex subunit 7. (565 aa)
	ENSOMEP00000034958	Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (412 aa)
	pkmyt1	Protein kinase, membrane associated tyrosine/threonine 1. (565 aa)
	LOC112149497	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (262 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1105 aa)
	ENSOMEP00000000163	Inositol 1,4,5-trisphosphate receptor, type 1b. (2649 aa)
	ins	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (113 aa)
	LOC112142568	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family. (293 aa)
	cdk1	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (303 aa)
	LOC112152400	Structural maintenance of chromosomes protein. (1241 aa)
	ccnb2	Cyclin B2; Belongs to the cyclin family. (394 aa)
	LOC112148460	Serine/threonine-protein phosphatase. (515 aa)
	igf1	Insulin-like growth factor 1. (184 aa)
	LOC112149544	3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2; Belongs to the 14-3-3 family. (247 aa)
	skp1	S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (376 aa)
	fbxw11	F-box and WD repeat domain containing 11a. (562 aa)
	LOC112161131	Ribosomal protein S6 kinase. (746 aa)
	LOC112156501	Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1. (551 aa)
	LOC112144834	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (244 aa)
	ENSOMEP00000003528	Transmembrane protein 82. (317 aa)
	ENSOMEP00000003958	Serine/threonine-protein phosphatase. (496 aa)
	LOC112137485	Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (577 aa)
	LOC112137465	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1453 aa)
	LOC112139901	Androgen receptor. (718 aa)
	LOC112147433	Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
	LOC112152311	Tyrosine-protein kinase receptor. (1413 aa)
	adcy6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1209 aa)
	prkaca	Uncharacterized protein; Belongs to the protein kinase superfamily. (359 aa)
	cpeb1	Cytoplasmic polyadenylation element binding protein 1b. (588 aa)
	LOC112146515	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (377 aa)
	ENSOMEP00000005785	Structural maintenance of chromosomes 3. (1124 aa)
	anapc11	APC11 anaphase promoting complex subunit 11 homolog (yeast). (84 aa)
	LOC112149155	Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (412 aa)
	mad2l2	Mitotic arrest deficient 2 like 2. (210 aa)
	ENSOMEP00000007288	CaMKII_AD domain-containing protein. (203 aa)
	espl1	Extra spindle pole bodies like 1, separase. (2141 aa)
	camk2a	Calcium/calmodulin-dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (478 aa)
	mapk1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
	spdya	Speedy/RINGO cell cycle regulator family member A. (317 aa)
	ENSOMEP00000008938	Protein kinase domain-containing protein. (530 aa)
	LOC112143003	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (252 aa)
	YWHAB	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b; Belongs to the 14-3-3 family. (244 aa)
	ENSOMEP00000009674	Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
	ENSOMEP00000009829	Non-specific serine/threonine protein kinase. (592 aa)
	ENSOMEP00000009874	MIR domain-containing protein. (214 aa)
	ENSOMEP00000009898	Inositol 1,4,5-trisphosphate receptor, type 2. (1588 aa)
	LOC112153403	Cytoplasmic polyadenylation element binding protein 4a. (741 aa)
	LOC112158927	IlGF domain-containing protein. (181 aa)
	mtrf1l	Mitochondrial translational release factor 1-like. (431 aa)
	fbxo5	F-box protein 5. (410 aa)
	ENSOMEP00000011806	Anaphase promoting complex subunit 1. (1855 aa)
	ENSOMEP00000012192	Adenylate cyclase 2b (brain); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (826 aa)
	ppp1cb	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
	calm2	Calmodulin 2a (phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
	LOC112153467	Uncharacterized protein. (678 aa)
	LOC112156983	Protein kinase domain-containing protein. (552 aa)
	LOC112143511	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1203 aa)
	LOC112153155	Ribosomal protein S6 kinase. (727 aa)
	LOC112153084	Uncharacterized protein. (181 aa)
	LOC112150580	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1114 aa)
	ENSOMEP00000013464	Protein phosphatase 2, regulatory subunit A, beta b. (647 aa)
	ENSOMEP00000013699	MIR domain-containing protein. (213 aa)
	ENSOMEP00000013717	Ion_trans domain-containing protein. (462 aa)
	cdc27	Cell division cycle 27. (802 aa)
	LOC112153053	Serine/threonine-protein phosphatase. (492 aa)
	rec8	REC8 meiotic recombination protein b. (568 aa)
	LOC112159424	Mitogen-activated protein kinase. (363 aa)
	ccnb1	Cyclin B1; Belongs to the cyclin family. (400 aa)
	ENSOMEP00000015819	Protein kinase domain-containing protein. (358 aa)
	aurka	Aurora kinase A; Belongs to the protein kinase superfamily. (427 aa)
	bub1	BUB1 mitotic checkpoint serine/threonine kinase. (1124 aa)
	LOC112146278	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (389 aa)
	LOC112146006	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
	LOC112158959	Ribosomal protein S6 kinase. (734 aa)
	PLK1	Serine/threonine-protein kinase PLK. (582 aa)
	LOC112152008	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (247 aa)
	anapc13	Anaphase promoting complex subunit 13. (74 aa)
	LOC112158855	Mitogen-activated protein kinase. (360 aa)
	LOC112142009	Serine/threonine-protein phosphatase. (522 aa)
	FBXO43	F-box protein 43. (561 aa)
	ENSOMEP00000018611	Uncharacterized protein. (730 aa)
	adcy8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1228 aa)
	ENSOMEP00000018799	STE20-like kinase b. (1070 aa)
	cdc26	Cell division cycle 26 homolog. (93 aa)
	map2k1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
	LOC112154198	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (325 aa)
	ccne1	Cyclin E1; Belongs to the cyclin family. (423 aa)
	ccne2	Cyclin E2; Belongs to the cyclin family. (395 aa)
	ENSOMEP00000020086	Uncharacterized protein. (97 aa)
	ppp1cc	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
	camk2b	Calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2. (539 aa)
	LOC112152089	Mitogen-activated protein kinase. (361 aa)
	LOC112139315	Mitogen-activated protein kinase. (361 aa)
	ENSOMEP00000021364	Inositol 1,4,5-trisphosphate receptor, type 1a. (2568 aa)
	mad1l1	Mitotic arrest deficient 1 like 1. (722 aa)
	ENSOMEP00000021559	Mitogen-activated protein kinase 12b. (358 aa)
	ENSOMEP00000021566	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (217 aa)
	calm2-2	Calmodulin 3. (149 aa)
	pgr	Progesterone receptor. (667 aa)

Your Current Organism:

Oryzias melastigma

NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY3	ADCY9	ENSOMEP00000034112	ENSOMEP00000027538	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.744
ADCY3	CPEB4	ENSOMEP00000034112	ENSOMEP00000025057	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Cytoplasmic polyadenylation element binding protein 4.	0.537
ADCY3	ENSOMEP00000007288	ENSOMEP00000034112	ENSOMEP00000007288	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	CaMKII_AD domain-containing protein.	0.658
ADCY3	ENSOMEP00000008938	ENSOMEP00000034112	ENSOMEP00000008938	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.609
ADCY3	ENSOMEP00000009674	ENSOMEP00000034112	ENSOMEP00000009674	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the calmodulin family.	0.661
ADCY3	ENSOMEP00000024440	ENSOMEP00000034112	ENSOMEP00000024440	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Cytoplasmic polyadenylation element binding protein 2.	0.537
ADCY3	ENSOMEP00000029103	ENSOMEP00000034112	ENSOMEP00000029103	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.658
ADCY3	ENSOMEP00000032467	ENSOMEP00000034112	ENSOMEP00000032467	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.641
ADCY3	ENSOMEP00000032690	ENSOMEP00000034112	ENSOMEP00000032690	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Cytoplasmic polyadenylation element binding protein 3.	0.561
ADCY3	LOC112137465	ENSOMEP00000034112	ENSOMEP00000004631	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.744
ADCY3	LOC112146515	ENSOMEP00000034112	ENSOMEP00000005650	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	0.716
ADCY3	LOC112147433	ENSOMEP00000034112	ENSOMEP00000004821	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.917
ADCY3	LOC112156501	ENSOMEP00000034112	ENSOMEP00000003298	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1.	0.609
ADCY3	LOC112156983	ENSOMEP00000034112	ENSOMEP00000012623	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.609
ADCY3	LOC112158536	ENSOMEP00000034112	ENSOMEP00000026127	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.641
ADCY3	LOC112159026	ENSOMEP00000034112	ENSOMEP00000033236	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.630
ADCY3	adcy5	ENSOMEP00000034112	ENSOMEP00000031870	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.630
ADCY3	adcy6	ENSOMEP00000034112	ENSOMEP00000005277	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.630
ADCY3	adcy8	ENSOMEP00000034112	ENSOMEP00000018689	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.641
ADCY3	calm2	ENSOMEP00000034112	ENSOMEP00000012334	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 2a (phosphorylase kinase, delta); Belongs to the calmodulin family.	0.888