(70 nodes) Ferroptosis network (Oryzias melastigma)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSOMEP00000029056	Uncharacterized protein. (130 aa)
	gss	Glutathione synthetase. (476 aa)
	ENSOMEP00000021469	Zgc:56235. (371 aa)
	map1lc3b	Microtubule-associated protein 1 light chain 3 beta. (126 aa)
	LOC112162297	Uncharacterized protein. (434 aa)
	xkrx	XK-related protein. (477 aa)
	LOC112156765	Cytochrome b-245, beta polypeptide (chronic granulomatous disease). (565 aa)
	LOC112151523	Transferrin receptor 1b. (770 aa)
	pgpep1	Pyroglutamyl-peptidase I. (216 aa)
	map1lc3a	Microtubule-associated protein 1 light chain 3 alpha. (138 aa)
	LOC112158025	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (176 aa)
	atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	LOC112160516	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (177 aa)
	PCBP2	Poly(rC) binding protein 2. (454 aa)
	XK	XK-related protein. (477 aa)
	LOC112153285	Microtubule-associated protein 1 light chain 3 gamma, like. (136 aa)
	LOC112149461	Aamy domain-containing protein. (528 aa)
	LOC112144842	Solute carrier family 11 member 2. (560 aa)
	ENSOMEP00000034883	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (112 aa)
	slc40a1	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (579 aa)
	LOC112147079	Acyl-CoA synthetase long chain family member 3b. (711 aa)
	LOC112147056	Serotransferrin; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate. (690 aa)
	STEAP3	STEAP family member 3, metalloreductase. (516 aa)
	acsl5	Acyl-CoA synthetase long chain family member 5. (707 aa)
	LOC112159715	Poly(rC) binding protein 2. (324 aa)
	hmox1	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (268 aa)
	ENSOMEP00000019940	Nuclear receptor coactivator 4. (369 aa)
	LOC112138558	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (176 aa)
	ENSOMEP00000019018	Uncharacterized protein. (289 aa)
	atg7	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (720 aa)
	pcbp3	Uncharacterized protein. (321 aa)
	ENSOMEP00000018421	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (375 aa)
	GPX4	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (112 aa)
	ACSL1	Acyl-CoA synthetase long chain family member 1. (732 aa)
	sat1	Spermidine/spermine N1-acetyltransferase 1b. (171 aa)
	acsl3	Uncharacterized protein. (719 aa)
	LOC112154619	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (174 aa)
	LOC112152863	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (177 aa)
	ENSOMEP00000015837	Voltage-dependent anion channel 3. (282 aa)
	LOC112157371	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (273 aa)
	nox1	NADPH oxidase 1. (565 aa)
	LOC112159759	Uncharacterized protein. (587 aa)
	VDAC2	Voltage dependent anion channel 2. (283 aa)
	LOC112149140	Si:dkey-202g17.3. (503 aa)
	lpcat3	Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (459 aa)
	LOC112156486	Spermidine/spermine N1-acetyltransferase family member 2a. (169 aa)
	acsl4	Acyl-CoA synthetase long chain family member 4a. (676 aa)
	slc7a11	Solute carrier family 7 member 11. (500 aa)
	LOC112150414	Ceruloplasmin; Belongs to the multicopper oxidase family. (1050 aa)
	LOC112156259	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (346 aa)
	map1lc3c	Microtubule-associated protein 1 light chain 3 gamma. (128 aa)
	LOC112148245	Acyl-CoA synthetase long chain family member 2. (711 aa)
	slc39a8	Solute carrier family 39 member 8. (453 aa)
	LOC112147141	Transferrin receptor 1a. (769 aa)
	ENSOMEP00000006762	Aamy domain-containing protein. (551 aa)
	LOC112157163	Acyl-CoA synthetase long chain family member 1a. (698 aa)
	ENSOMEP00000005497	Serotransferrin; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate. (680 aa)
	LOC112161679	Voltage-dependent anion channel 2. (283 aa)
	LOC112142411	AMP-binding domain-containing protein. (722 aa)
	LOC112155973	Si:ch73-352p4.8. (483 aa)
	LOC112145584	Uncharacterized protein. (484 aa)
	LOC112138694	Spermidine/spermine N1-acetyltransferase family member 2b. (173 aa)
	ENSOMEP00000001720	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (183 aa)
	gclc	Glutamate-cysteine ligase, catalytic subunit. (630 aa)
	ENSOMEP00000027107	Solute carrier family 39 member 14. (478 aa)
	gclm	Glutamate-cysteine ligase, modifier subunit. (271 aa)
	steap2	STEAP family member 2, metalloreductase. (515 aa)
	meltf	Serotransferrin; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate. (725 aa)
	LOC112150413	Ceruloplasmin; Belongs to the multicopper oxidase family. (1073 aa)
	LOC112159114	Uncharacterized protein. (457 aa)

Your Current Organism:

Oryzias melastigma

NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACSL1	LOC112142411	ENSOMEP00000017825	ENSOMEP00000003246	Acyl-CoA synthetase long chain family member 1.	AMP-binding domain-containing protein.	0.852
ACSL1	LOC112147079	ENSOMEP00000017825	ENSOMEP00000035683	Acyl-CoA synthetase long chain family member 1.	Acyl-CoA synthetase long chain family member 3b.	0.883
ACSL1	LOC112148245	ENSOMEP00000017825	ENSOMEP00000007796	Acyl-CoA synthetase long chain family member 1.	Acyl-CoA synthetase long chain family member 2.	0.853
ACSL1	LOC112156259	ENSOMEP00000017825	ENSOMEP00000009309	Acyl-CoA synthetase long chain family member 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.879
ACSL1	LOC112157163	ENSOMEP00000017825	ENSOMEP00000006381	Acyl-CoA synthetase long chain family member 1.	Acyl-CoA synthetase long chain family member 1a.	0.774
ACSL1	acsl3	ENSOMEP00000017825	ENSOMEP00000017394	Acyl-CoA synthetase long chain family member 1.	Uncharacterized protein.	0.831
ACSL1	acsl4	ENSOMEP00000017825	ENSOMEP00000012010	Acyl-CoA synthetase long chain family member 1.	Acyl-CoA synthetase long chain family member 4a.	0.884
ACSL1	acsl5	ENSOMEP00000017825	ENSOMEP00000024427	Acyl-CoA synthetase long chain family member 1.	Acyl-CoA synthetase long chain family member 5.	0.799
ENSOMEP00000001720	gss	ENSOMEP00000001720	ENSOMEP00000029428	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	Glutathione synthetase.	0.794
ENSOMEP00000005497	LOC112147079	ENSOMEP00000005497	ENSOMEP00000035683	Serotransferrin; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate.	Acyl-CoA synthetase long chain family member 3b.	0.415
ENSOMEP00000005497	LOC112147141	ENSOMEP00000005497	ENSOMEP00000006931	Serotransferrin; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate.	Transferrin receptor 1a.	0.821
ENSOMEP00000005497	LOC112151523	ENSOMEP00000005497	ENSOMEP00000021868	Serotransferrin; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate.	Transferrin receptor 1b.	0.843
ENSOMEP00000005497	acsl3	ENSOMEP00000005497	ENSOMEP00000017394	Serotransferrin; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate.	Uncharacterized protein.	0.415
ENSOMEP00000005497	acsl4	ENSOMEP00000005497	ENSOMEP00000012010	Serotransferrin; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate.	Acyl-CoA synthetase long chain family member 4a.	0.415
ENSOMEP00000006762	LOC112149461	ENSOMEP00000006762	ENSOMEP00000033656	Aamy domain-containing protein.	Aamy domain-containing protein.	0.903
ENSOMEP00000006762	LOC112155973	ENSOMEP00000006762	ENSOMEP00000003207	Aamy domain-containing protein.	Si:ch73-352p4.8.	0.979
ENSOMEP00000006762	slc7a11	ENSOMEP00000006762	ENSOMEP00000009510	Aamy domain-containing protein.	Solute carrier family 7 member 11.	0.979
ENSOMEP00000015837	ENSOMEP00000021469	ENSOMEP00000015837	ENSOMEP00000021469	Voltage-dependent anion channel 3.	Zgc:56235.	0.545
ENSOMEP00000015837	ENSOMEP00000029056	ENSOMEP00000015837	ENSOMEP00000029056	Voltage-dependent anion channel 3.	Uncharacterized protein.	0.549
ENSOMEP00000015837	LOC112161679	ENSOMEP00000015837	ENSOMEP00000004556	Voltage-dependent anion channel 3.	Voltage-dependent anion channel 2.	0.822