(86 nodes) VEGF signaling pathway network (Oryzias melastigma)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ptgs2	Prostaglandin-endoperoxide synthase 2b. (607 aa)
	LOC112144491	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (397 aa)
	LOC112137352	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (680 aa)
	LOC112162837	Heat shock protein, alpha-crystallin-related, b15; Belongs to the small heat shock protein (HSP20) family. (198 aa)
	ENSOMEP00000002349	Uncharacterized protein. (585 aa)
	LOC112148460	Serine/threonine-protein phosphatase. (515 aa)
	CDC42	Cell division cycle 42. (191 aa)
	gem	GTP binding protein overexpressed in skeletal muscle. (305 aa)
	ENSOMEP00000003958	Serine/threonine-protein phosphatase. (496 aa)
	ENSOMEP00000005257	Phospholipase A2. (725 aa)
	ENSOMEP00000005632	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (483 aa)
	ENSOMEP00000006129	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1078 aa)
	LOC112150209	Leupaxin. (389 aa)
	raf1	Raf-1 proto-oncogene, serine/threonine kinase a. (677 aa)
	shc2	SHC (Src homology 2 domain containing) transforming protein 2. (696 aa)
	bad	BCL2 associated agonist of cell death b. (169 aa)
	mapk1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
	SPHK1	Sphingosine kinase 1. (511 aa)
	LOC112147562	Uncharacterized protein. (466 aa)
	LOC112143277	Sphingosine kinase 2. (861 aa)
	KRAS	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	LOC112161991	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	ENSOMEP00000010152	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (644 aa)
	ENSOMEP00000010866	FERM domain-containing protein. (197 aa)
	ENSOMEP00000010878	Uncharacterized protein. (104 aa)
	ENSOMEP00000010900	Protein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1125 aa)
	LOC112148625	Si:dkey-1k23.3; Belongs to the small heat shock protein (HSP20) family. (285 aa)
	LOC112143725	Uncharacterized protein. (191 aa)
	src	Tyrosine-protein kinase. (550 aa)
	LOC112144596	RHD domain-containing protein. (887 aa)
	ENSOMEP00000013662	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1202 aa)
	kdr	Kinase insert domain receptor (a type III receptor tyrosine kinase); Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1327 aa)
	pik3r3	Phosphoinositide-3-kinase, regulatory subunit 3b (gamma). (723 aa)
	LOC112153053	Serine/threonine-protein phosphatase. (492 aa)
	rac2	Rac family small GTPase 2. (192 aa)
	LOC112137131	Uncharacterized protein. (191 aa)
	LOC112159424	Mitogen-activated protein kinase. (363 aa)
	LOC112140005	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	LOC112158705	Tyrosine-protein kinase. (551 aa)
	ENSOMEP00000015812	SH2 domain-containing protein. (509 aa)
	rrad	Ras-related associated with diabetes. (458 aa)
	LOC112148168	Uncharacterized protein. (621 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
	LOC112146278	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (389 aa)
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	MAPKAPK2	MAPK activated protein kinase 2a; Belongs to the protein kinase superfamily. (384 aa)
	jmjd7	Jumonji domain containing 7. (311 aa)
	plcg2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1247 aa)
	LOC112158855	Mitogen-activated protein kinase. (360 aa)
	LOC112142009	Serine/threonine-protein phosphatase. (522 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
	map2k1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
	TGFB1I1	Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (479 aa)
	pik3cd	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
	LOC112152089	Mitogen-activated protein kinase. (361 aa)
	LOC112139315	Mitogen-activated protein kinase. (361 aa)
	ENSOMEP00000021559	Mitogen-activated protein kinase 12b. (358 aa)
	LOC112144774	Cell division cycle 42. (191 aa)
	ENSOMEP00000022558	Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (524 aa)
	map2k2	Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (397 aa)
	RAC1	Rac family small GTPase 1a. (204 aa)
	LOC112147412	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC112157322	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (532 aa)
	ppp1r14b	Protein phosphatase 1, regulatory (inhibitor) subunit 14Bb. (128 aa)
	REM1	RRAD and GEM like GTPase 1. (306 aa)
	casp9	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (434 aa)
	ENSOMEP00000026763	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (624 aa)
	LOC112138447	Uncharacterized protein. (716 aa)
	MAPKAPK3	MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (415 aa)
	LOC112146455	Uncharacterized protein. (193 aa)
	ENSOMEP00000028270	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (699 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	plcg1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1311 aa)
	ENSOMEP00000029714	Protein kinase domain-containing protein. (102 aa)
	LOC112162359	Rac family small GTPase 3b. (192 aa)
	lrrc45	Leucine rich repeat containing 45. (673 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (869 aa)
	pik3r1	Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (728 aa)
	LOC112146394	Zgc:55558. (186 aa)
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	ENSOMEP00000032648	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (253 aa)
	LOC112146599	DAGKc domain-containing protein. (560 aa)
	ppp3r1	Uncharacterized protein. (170 aa)
	ENSOMEP00000035932	Mitogen-activated protein kinase. (351 aa)
	LOC112139281	Uncharacterized protein. (176 aa)

Your Current Organism:

Oryzias melastigma

NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	CSDE1	ENSOMEP00000003168	ENSOMEP00000031024	Cell division cycle 42.	Cold shock domain containing E1, RNA-binding.	0.610
CDC42	ENSOMEP00000002349	ENSOMEP00000003168	ENSOMEP00000002349	Cell division cycle 42.	Uncharacterized protein.	0.529
CDC42	ENSOMEP00000005632	ENSOMEP00000003168	ENSOMEP00000005632	Cell division cycle 42.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.528
CDC42	ENSOMEP00000006129	ENSOMEP00000003168	ENSOMEP00000006129	Cell division cycle 42.	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.854
CDC42	ENSOMEP00000010866	ENSOMEP00000003168	ENSOMEP00000010866	Cell division cycle 42.	FERM domain-containing protein.	0.546
CDC42	ENSOMEP00000010878	ENSOMEP00000003168	ENSOMEP00000010878	Cell division cycle 42.	Uncharacterized protein.	0.546
CDC42	ENSOMEP00000010900	ENSOMEP00000003168	ENSOMEP00000010900	Cell division cycle 42.	Protein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.546
CDC42	ENSOMEP00000013662	ENSOMEP00000003168	ENSOMEP00000013662	Cell division cycle 42.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.577
CDC42	ENSOMEP00000021559	ENSOMEP00000003168	ENSOMEP00000021559	Cell division cycle 42.	Mitogen-activated protein kinase 12b.	0.891
CDC42	ENSOMEP00000022558	ENSOMEP00000003168	ENSOMEP00000022558	Cell division cycle 42.	Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family.	0.599
CDC42	ENSOMEP00000029714	ENSOMEP00000003168	ENSOMEP00000029714	Cell division cycle 42.	Protein kinase domain-containing protein.	0.724
CDC42	ENSOMEP00000035932	ENSOMEP00000003168	ENSOMEP00000035932	Cell division cycle 42.	Mitogen-activated protein kinase.	0.911
CDC42	KRAS	ENSOMEP00000003168	ENSOMEP00000010002	Cell division cycle 42.	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog.	0.610
CDC42	LOC112137131	ENSOMEP00000003168	ENSOMEP00000014906	Cell division cycle 42.	Uncharacterized protein.	0.628
CDC42	LOC112138447	ENSOMEP00000003168	ENSOMEP00000027004	Cell division cycle 42.	Uncharacterized protein.	0.781
CDC42	LOC112139281	ENSOMEP00000003168	ENSOMEP00000036040	Cell division cycle 42.	Uncharacterized protein.	0.628
CDC42	LOC112139315	ENSOMEP00000003168	ENSOMEP00000021142	Cell division cycle 42.	Mitogen-activated protein kinase.	0.880
CDC42	LOC112140005	ENSOMEP00000003168	ENSOMEP00000015355	Cell division cycle 42.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.528
CDC42	LOC112143725	ENSOMEP00000003168	ENSOMEP00000012109	Cell division cycle 42.	Uncharacterized protein.	0.860
CDC42	LOC112144491	ENSOMEP00000003168	ENSOMEP00000000117	Cell division cycle 42.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.603