(133 nodes) Hippo signaling pathway - multiple species network (Oryzias melastigma)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSOMEP00000002262	Uncharacterized protein. (859 aa)
	ENSOMEP00000023207	Uncharacterized protein. (844 aa)
	ENSOMEP00000023177	Uncharacterized protein. (833 aa)
	ENSOMEP00000023173	Uncharacterized protein. (823 aa)
	fat1	FAT atypical cadherin 1a. (4652 aa)
	RASSF1	Ras association domain family member 1. (364 aa)
	cdh11	Cadherin 11, type 2, OB-cadherin (osteoblast); Cadherins are calcium-dependent cell adhesion proteins. (817 aa)
	yap1	Yes-associated protein 1. (458 aa)
	frmd6	FERM domain containing 6. (605 aa)
	LOC112152060	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (2549 aa)
	ENSOMEP00000020467	Uncharacterized protein. (820 aa)
	ENSOMEP00000020441	Uncharacterized protein. (843 aa)
	ENSOMEP00000020385	Uncharacterized protein. (1067 aa)
	ENSOMEP00000020358	Uncharacterized protein. (830 aa)
	LOC112143235	Si:dkey-22o22.2; Cadherins are calcium-dependent cell adhesion proteins. (2936 aa)
	fat2	FAT atypical cadherin 2. (4354 aa)
	LOC112160461	Si:ch211-186j3.6; Cadherins are calcium-dependent cell adhesion proteins. (2943 aa)
	CDH8	Cadherin 8; Cadherins are calcium-dependent cell adhesion proteins. (800 aa)
	LOC112136194	Ras association domain family member 6. (342 aa)
	LOC112153237	Protocadherin 11. (1265 aa)
	LOC112155741	Chloride channel protein. (835 aa)
	rassf2	Ras association domain family member 2a. (327 aa)
	cdh23	Cadherin-related 23. (3362 aa)
	LOC112139586	Uncharacterized protein. (862 aa)
	LOC112141162	TEA domain family member 1a. (427 aa)
	clcn3	Chloride channel protein. (879 aa)
	wtip	WT1 interacting protein. (686 aa)
	ENSOMEP00000014843	Cadherin_2 domain-containing protein. (84 aa)
	tead3	Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (493 aa)
	pcdh17	Protocadherin 17. (1141 aa)
	pcdh9	Protocadherin 9. (1193 aa)
	LOC112155914	Ajuba LIM protein. (695 aa)
	ENSOMEP00000013273	Uncharacterized protein. (847 aa)
	ENSOMEP00000013266	Uncharacterized protein. (829 aa)
	LOC112163363	MOB kinase activator 1Bb. (216 aa)
	pcdh19	Protocadherin 19. (1094 aa)
	ENSOMEP00000012652	Dachsous cadherin-related 1b. (3282 aa)
	pcdh7	Protocadherin 7b. (1256 aa)
	CDHR1	Cadherin related family member 1. (862 aa)
	ENSOMEP00000010268	Uncharacterized protein. (857 aa)
	LIMD1	LIM domains containing 1. (538 aa)
	cdhr2	Uncharacterized protein. (1282 aa)
	PCDH8	Protocadherin 8. (1011 aa)
	LOC112138364	Uncharacterized protein. (848 aa)
	LOC112153565	Protocadherin 18b. (1239 aa)
	LOC112153182	Protocadherin 10b. (989 aa)
	LOC112137378	Protocadherin 10a. (975 aa)
	ENSOMEP00000006737	TEA domain-containing protein. (407 aa)
	LOC112142615	Protocadherin 1a. (1191 aa)
	LOC112155396	Chondromodulin. (330 aa)
	LOC112155571	Protocadherin 8. (976 aa)
	LOC112154839	Protocadherin 8. (964 aa)
	ENSOMEP00000005027	HAUS augmin-like complex, subunit 4. (365 aa)
	LOC112144780	Ras association domain family member 1. (356 aa)
	LOC112153634	Si:ch73-233f7.1. (974 aa)
	LOC112153660	Protocadherin b. (799 aa)
	ENSOMEP00000002923	Uncharacterized protein. (795 aa)
	ENSOMEP00000002916	Uncharacterized protein. (787 aa)
	ENSOMEP00000002879	Uncharacterized protein. (783 aa)
	ENSOMEP00000002857	Uncharacterized protein. (289 aa)
	ENSOMEP00000002840	Uncharacterized protein. (778 aa)
	ENSOMEP00000002832	Cadherin_2 domain-containing protein. (100 aa)
	ENSOMEP00000002824	Si:ch73-379j16.2. (652 aa)
	ENSOMEP00000002816	Uncharacterized protein. (762 aa)
	ENSOMEP00000002812	Cadherin_2 domain-containing protein. (103 aa)
	ENSOMEP00000002802	Uncharacterized protein. (788 aa)
	ENSOMEP00000002782	Protocadherin 2 alpha a 15. (588 aa)
	ENSOMEP00000002744	Cadherin_2 domain-containing protein. (102 aa)
	ENSOMEP00000002723	Uncharacterized protein. (310 aa)
	ENSOMEP00000002713	Protocadherin 2 alpha a 15. (879 aa)
	LOC112153546	Uncharacterized protein. (885 aa)
	LOC112153545	Uncharacterized protein. (892 aa)
	ENSOMEP00000002553	Protocadherin 2 alpha c. (953 aa)
	ENSOMEP00000002513	Protocadherin 2 alpha b2. (789 aa)
	ENSOMEP00000002475	Uncharacterized protein. (898 aa)
	LOC112153679	Uncharacterized protein. (799 aa)
	ENSOMEP00000002386	Uncharacterized protein. (660 aa)
	LOC112153681	Uncharacterized protein. (855 aa)
	ENSOMEP00000002356	Uncharacterized protein. (808 aa)
	ENSOMEP00000002342	Uncharacterized protein. (822 aa)
	ENSOMEP00000002319	Uncharacterized protein. (811 aa)
	ENSOMEP00000002288	Uncharacterized protein. (934 aa)
	ENSOMEP00000002280	Uncharacterized protein. (277 aa)
	LOC112153272	Uncharacterized protein. (847 aa)
	ENSOMEP00000002218	Uncharacterized protein. (814 aa)
	ENSOMEP00000002202	Uncharacterized protein. (789 aa)
	ENSOMEP00000002185	Uncharacterized protein. (448 aa)
	LOC112144430	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (764 aa)
	ENSOMEP00000001718	Uncharacterized protein. (818 aa)
	ENSOMEP00000001708	Uncharacterized protein. (977 aa)
	ENSOMEP00000001706	Si:dkey-1m11.5. (499 aa)
	LOC112157801	Protocadherin 18a. (1173 aa)
	ENSOMEP00000001423	Ras association domain family member 4a. (298 aa)
	dchs2	Uncharacterized protein. (3256 aa)
	LOC112149171	Dachsous cadherin-related 1a. (3277 aa)
	LOC112148135	MOB kinase activator 1A. (216 aa)
	TEAD1	TEA domain family member 1b. (474 aa)
	LOC112162215	FERM domain-containing protein. (579 aa)
	CDH7	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (799 aa)
	ENSOMEP00000023539	Uncharacterized protein. (283 aa)
	ENSOMEP00000023546	Uncharacterized protein. (836 aa)
	ENSOMEP00000023552	Cadherin_2 domain-containing protein. (100 aa)
	LOC112153668	Uncharacterized protein. (846 aa)
	ENSOMEP00000023602	Uncharacterized protein. (779 aa)
	ENSOMEP00000023613	Uncharacterized protein. (821 aa)
	ENSOMEP00000023628	Uncharacterized protein. (902 aa)
	ENSOMEP00000023642	Uncharacterized protein. (786 aa)
	ENSOMEP00000023652	Uncharacterized protein. (798 aa)
	LOC112161434	Cadherin-related family member 1a. (872 aa)
	wwc3	WWC family member 3. (1141 aa)
	PCDH17	Protocadherin 17. (1091 aa)
	ENSOMEP00000025383	Cadherin_tail domain-containing protein. (161 aa)
	ENSOMEP00000025612	Uncharacterized protein. (878 aa)
	LOC112143067	Uncharacterized protein. (983 aa)
	PCDHAC2	Protocadherin alpha subfamily C, 2. (913 aa)
	lats2	Large tumor suppressor kinase 2. (1163 aa)
	ENSOMEP00000027967	Uncharacterized protein. (899 aa)
	cnmd	BRICHOS domain-containing protein. (313 aa)
	LOC112157219	Protocadherin 7a. (1368 aa)
	ENSOMEP00000030454	Uncharacterized protein. (222 aa)
	ENSOMEP00000030540	TEA domain-containing protein. (417 aa)
	LOC112156752	Chloride channel protein. (769 aa)
	lats1	Large tumor suppressor kinase 1. (1071 aa)
	fat4	FAT atypical cadherin 4. (4976 aa)
	LOC112137819	Uncharacterized protein. (1248 aa)
	ENSOMEP00000035203	Uncharacterized protein. (838 aa)
	sav1	Salvador family WW domain containing protein 1. (403 aa)
	wwc1	WW and C2 domain containing 1. (1117 aa)
	ENSOMEP00000023258	Uncharacterized protein. (259 aa)
	ENSOMEP00000023343	Uncharacterized protein. (880 aa)
	ENSOMEP00000023351	Uncharacterized protein. (683 aa)
	ENSOMEP00000023401	Cadherin_2 domain-containing protein. (110 aa)
	ENSOMEP00000023531	Cadherin_2 domain-containing protein. (117 aa)

Your Current Organism:

Oryzias melastigma

NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDH7	fat1	ENSOMEP00000000304	ENSOMEP00000022699	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	FAT atypical cadherin 1a.	0.617
CDH7	fat2	ENSOMEP00000000304	ENSOMEP00000019743	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	FAT atypical cadherin 2.	0.617
CDH8	fat1	ENSOMEP00000018636	ENSOMEP00000022699	Cadherin 8; Cadherins are calcium-dependent cell adhesion proteins.	FAT atypical cadherin 1a.	0.617
CDH8	fat2	ENSOMEP00000018636	ENSOMEP00000019743	Cadherin 8; Cadherins are calcium-dependent cell adhesion proteins.	FAT atypical cadherin 2.	0.617
CDHR1	fat1	ENSOMEP00000010293	ENSOMEP00000022699	Cadherin related family member 1.	FAT atypical cadherin 1a.	0.617
CDHR1	fat2	ENSOMEP00000010293	ENSOMEP00000019743	Cadherin related family member 1.	FAT atypical cadherin 2.	0.617
ENSOMEP00000001423	LOC112144780	ENSOMEP00000001423	ENSOMEP00000004660	Ras association domain family member 4a.	Ras association domain family member 1.	0.409
ENSOMEP00000001423	RASSF1	ENSOMEP00000001423	ENSOMEP00000022302	Ras association domain family member 4a.	Ras association domain family member 1.	0.409
ENSOMEP00000001423	sav1	ENSOMEP00000001423	ENSOMEP00000035590	Ras association domain family member 4a.	Salvador family WW domain containing protein 1.	0.582
ENSOMEP00000001706	ENSOMEP00000001718	ENSOMEP00000001706	ENSOMEP00000001718	Si:dkey-1m11.5.	Uncharacterized protein.	0.780
ENSOMEP00000001706	fat1	ENSOMEP00000001706	ENSOMEP00000022699	Si:dkey-1m11.5.	FAT atypical cadherin 1a.	0.632
ENSOMEP00000001706	fat2	ENSOMEP00000001706	ENSOMEP00000019743	Si:dkey-1m11.5.	FAT atypical cadherin 2.	0.632
ENSOMEP00000001708	ENSOMEP00000001718	ENSOMEP00000001708	ENSOMEP00000001718	Uncharacterized protein.	Uncharacterized protein.	0.875
ENSOMEP00000001708	fat1	ENSOMEP00000001708	ENSOMEP00000022699	Uncharacterized protein.	FAT atypical cadherin 1a.	0.632
ENSOMEP00000001708	fat2	ENSOMEP00000001708	ENSOMEP00000019743	Uncharacterized protein.	FAT atypical cadherin 2.	0.632
ENSOMEP00000001718	ENSOMEP00000001706	ENSOMEP00000001718	ENSOMEP00000001706	Uncharacterized protein.	Si:dkey-1m11.5.	0.780
ENSOMEP00000001718	ENSOMEP00000001708	ENSOMEP00000001718	ENSOMEP00000001708	Uncharacterized protein.	Uncharacterized protein.	0.875
ENSOMEP00000001718	fat1	ENSOMEP00000001718	ENSOMEP00000022699	Uncharacterized protein.	FAT atypical cadherin 1a.	0.632
ENSOMEP00000001718	fat2	ENSOMEP00000001718	ENSOMEP00000019743	Uncharacterized protein.	FAT atypical cadherin 2.	0.632
ENSOMEP00000002185	fat1	ENSOMEP00000002185	ENSOMEP00000022699	Uncharacterized protein.	FAT atypical cadherin 1a.	0.441