STRINGSTRING
PLCB2 PLCB2 WNT7A WNT7A wnt4 wnt4 LOC112148434 LOC112148434 LOC112137352 LOC112137352 LOC112161697 LOC112161697 tyr tyr ENSOMEP00000001910 ENSOMEP00000001910 ENSOMEP00000002278 ENSOMEP00000002278 tcf7 tcf7 wnt3 wnt3 LOC112156501 LOC112156501 gem gem LOC112158166 LOC112158166 LOC112146043 LOC112146043 tyrp1 tyrp1 ENSOMEP00000004505 ENSOMEP00000004505 LOC112137465 LOC112137465 LOC112147433 LOC112147433 GNAS GNAS adcy6 adcy6 LOC112154771 LOC112154771 prkaca prkaca LOC112146515 LOC112146515 ENSOMEP00000006440 ENSOMEP00000006440 LOC112152881 LOC112152881 kitlg kitlg wnt3a wnt3a raf1 raf1 LOC112155970 LOC112155970 ENSOMEP00000007133 ENSOMEP00000007133 ENSOMEP00000007288 ENSOMEP00000007288 gsk3b gsk3b LOC112153984 LOC112153984 camk2a camk2a mapk1 mapk1 LOC112152429 LOC112152429 ENSOMEP00000008938 ENSOMEP00000008938 LOC112144555 LOC112144555 LOC112163036 LOC112163036 ENSOMEP00000009373 ENSOMEP00000009373 ENSOMEP00000009674 ENSOMEP00000009674 ENSOMEP00000009742 ENSOMEP00000009742 KRAS KRAS ENSOMEP00000010152 ENSOMEP00000010152 ENSOMEP00000012058 ENSOMEP00000012058 wnt6 wnt6 LOC112143691 LOC112143691 ENSOMEP00000012192 ENSOMEP00000012192 LOC112156702 LOC112156702 calm2 calm2 LOC112156983 LOC112156983 LOC112143511 LOC112143511 LOC112157547 LOC112157547 LOC112150580 LOC112150580 LOC112153752 LOC112153752 TYR TYR ENSOMEP00000013710 ENSOMEP00000013710 LOC112159194 LOC112159194 ENSOMEP00000014118 ENSOMEP00000014118 LOC112155243 LOC112155243 ENSOMEP00000015352 ENSOMEP00000015352 wnt1 wnt1 rrad rrad ENSOMEP00000016565 ENSOMEP00000016565 LOC112146278 LOC112146278 hras hras LOC112145513 LOC112145513 ENSOMEP00000017783 ENSOMEP00000017783 PLCB4 PLCB4 PLCB1 PLCB1 ENSOMEP00000018189 ENSOMEP00000018189 LOC112147604 LOC112147604 adcy8 adcy8 PRKCB PRKCB LOC112158895 LOC112158895 LOC112148825 LOC112148825 map2k1 map2k1 LOC112143791 LOC112143791 LOC112136885 LOC112136885 ENSOMEP00000020911 ENSOMEP00000020911 camk2b camk2b calm2-2 calm2-2 LOC112145165 LOC112145165 ENSOMEP00000022713 ENSOMEP00000022713 fzd4 fzd4 LOC112145176 LOC112145176 ENSOMEP00000023328 ENSOMEP00000023328 dvl1 dvl1 creb3l4 creb3l4 LOC112162929 LOC112162929 LOC112147429 LOC112147429 ENSOMEP00000024300 ENSOMEP00000024300 map2k2 map2k2 ENSOMEP00000024995 ENSOMEP00000024995 fzd6 fzd6 wnt2 wnt2 dct dct LOC112142230 LOC112142230 wnt9a wnt9a calml4 calml4 LOC112158536 LOC112158536 REM1 REM1 ENSOMEP00000026430 ENSOMEP00000026430 LOC112159847 LOC112159847 LOC112150368 LOC112150368 ENSOMEP00000026763 ENSOMEP00000026763 LOC112147013 LOC112147013 creb3l1 creb3l1 ADCY9 ADCY9 LOC112155939 LOC112155939 crebbp crebbp LOC112148818 LOC112148818 LOC112147829 LOC112147829 FZD3 FZD3 ENSOMEP00000028270 ENSOMEP00000028270 dvl2 dvl2 wnt11 wnt11 LOC112153744 LOC112153744 LOC112153646 LOC112153646 ENSOMEP00000029103 ENSOMEP00000029103 LOC112162582 LOC112162582 LOC112159843 LOC112159843 calm2-3 calm2-3 LOC112153035 LOC112153035 tcf7l2 tcf7l2 fzd3 fzd3 LOC112161708 LOC112161708 ENSOMEP00000030778 ENSOMEP00000030778 kit kit ENSOMEP00000031022 ENSOMEP00000031022 CSDE1 CSDE1 adcy7 adcy7 ctnnb1 ctnnb1 LOC112146394 LOC112146394 POMC POMC adcy5 adcy5 wnt10b-2 wnt10b-2 LOC112144558 LOC112144558 ENSOMEP00000032467 ENSOMEP00000032467 ENSOMEP00000032569 ENSOMEP00000032569 prkacb prkacb LOC112159026 LOC112159026 LOC112156435 LOC112156435 wnt16 wnt16 ADCY3 ADCY3 ENSOMEP00000035988 ENSOMEP00000035988 wnt9b wnt9b creb3l2 creb3l2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1236 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
wnt4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (405 aa)
LOC112148434Uncharacterized protein. (359 aa)
LOC112137352Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (680 aa)
LOC1121616971-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1164 aa)
tyrTyrosinase. (540 aa)
ENSOMEP00000001910Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (325 aa)
ENSOMEP00000002278Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (572 aa)
tcf7Transcription factor 7. (525 aa)
wnt3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
LOC112156501Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1. (551 aa)
gemGTP binding protein overexpressed in skeletal muscle. (305 aa)
LOC112158166Uncharacterized protein. (354 aa)
LOC112146043E1A binding protein p300 b. (2771 aa)
tyrp1Tyrosinase related protein 1. (521 aa)
ENSOMEP00000004505CREB binding protein a. (2295 aa)
LOC112137465Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1453 aa)
LOC112147433Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
GNASGNAS complex locus. (379 aa)
adcy6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1209 aa)
LOC112154771Endothelin receptor type Bb; Belongs to the G-protein coupled receptor 1 family. (427 aa)
prkacaUncharacterized protein; Belongs to the protein kinase superfamily. (359 aa)
LOC112146515Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (377 aa)
ENSOMEP00000006440Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa)
LOC112152881Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
kitlgKit ligand a. (257 aa)
wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (368 aa)
raf1Raf-1 proto-oncogene, serine/threonine kinase a. (677 aa)
LOC1121559701-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1242 aa)
ENSOMEP00000007133Uncharacterized protein. (139 aa)
ENSOMEP00000007288CaMKII_AD domain-containing protein. (203 aa)
gsk3bGlycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (421 aa)
LOC112153984E1A binding protein p300 a. (2690 aa)
camk2aCalcium/calmodulin-dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (478 aa)
mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
LOC112152429Uncharacterized protein. (354 aa)
ENSOMEP00000008938Protein kinase domain-containing protein. (530 aa)
LOC112144555Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a. (355 aa)
LOC112163036Uncharacterized protein. (359 aa)
ENSOMEP00000009373Uncharacterized protein. (217 aa)
ENSOMEP00000009674Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
ENSOMEP00000009742Uncharacterized protein. (238 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
ENSOMEP00000010152Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (644 aa)
ENSOMEP00000012058Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa)
wnt6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
LOC112143691Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
ENSOMEP00000012192Adenylate cyclase 2b (brain); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (826 aa)
LOC112156702cAMP responsive element binding protein 1. (340 aa)
calm2Calmodulin 2a (phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
LOC112156983Protein kinase domain-containing protein. (552 aa)
LOC112143511Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1203 aa)
LOC112157547Tyrosinase-related protein 1b. (528 aa)
LOC112150580Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1114 aa)
LOC112153752G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (412 aa)
TYRTyrosinase. (544 aa)
ENSOMEP00000013710Uncharacterized protein. (354 aa)
LOC112159194Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
ENSOMEP00000014118Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (578 aa)
LOC112155243cAMP responsive element binding protein 1b. (328 aa)
ENSOMEP00000015352DIX domain-containing protein. (55 aa)
wnt1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
rradRas-related associated with diabetes. (458 aa)
ENSOMEP00000016565Dishevelled segment polarity protein 3a. (656 aa)
LOC112146278Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (389 aa)
hrasHRas proto-oncogene, GTPase a. (189 aa)
LOC112145513GNAS complex locus. (379 aa)
ENSOMEP00000017783cAMP responsive element binding protein 3-like 3a. (418 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1093 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1244 aa)
ENSOMEP00000018189Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
LOC112147604BZIP domain-containing protein. (411 aa)
adcy8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1228 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
LOC112158895Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (354 aa)
LOC112148825cAMP responsive element binding protein 3-like 3 like. (487 aa)
map2k1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
LOC112143791Uncharacterized protein. (1619 aa)
LOC112136885Endothelin 1. (202 aa)
ENSOMEP00000020911Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (560 aa)
camk2bCalcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2. (539 aa)
calm2-2Calmodulin 3. (149 aa)
LOC112145165Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b. (355 aa)
ENSOMEP00000022713Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b. (356 aa)
fzd4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (525 aa)
LOC112145176Melanocyte inducing transcription factor a. (401 aa)
ENSOMEP00000023328Frizzled class receptor 9b; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa)
dvl1Dishevelled segment polarity protein 1a. (728 aa)
creb3l4BZIP domain-containing protein. (383 aa)
LOC112162929HMG box domain-containing protein. (539 aa)
LOC112147429Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1153 aa)
ENSOMEP00000024300Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
map2k2Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (397 aa)
ENSOMEP00000024995Lymphoid enhancer-binding factor 1. (363 aa)
fzd6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (680 aa)
wnt2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
dctDopachrome tautomerase. (510 aa)
LOC112142230Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (528 aa)
wnt9aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (375 aa)
calml4Calmodulin-like 4a. (153 aa)
LOC112158536Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1187 aa)
REM1RRAD and GEM like GTPase 1. (306 aa)
ENSOMEP00000026430HMG box domain-containing protein. (293 aa)
LOC112159847Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (347 aa)
LOC112150368Guanine nucleotide binding protein (G protein), alpha 11a (Gq class). (359 aa)
ENSOMEP00000026763Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (624 aa)
LOC112147013Uncharacterized protein. (371 aa)
creb3l1cAMP responsive element binding protein 3-like 1. (482 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1419 aa)
LOC112155939Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
crebbpCREB binding protein b. (2411 aa)
LOC112148818Transcription factor 7 like 1b. (577 aa)
LOC112147829Endothelin receptor Ba; Belongs to the G-protein coupled receptor 1 family. (419 aa)
FZD3Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (760 aa)
ENSOMEP00000028270Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (699 aa)
dvl2Dishevelled segment polarity protein 2. (767 aa)
wnt11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
LOC112153744Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (336 aa)
LOC112153646Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
ENSOMEP00000029103Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (498 aa)
LOC112162582Uncharacterized protein. (211 aa)
LOC112159843Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (379 aa)
calm2-3Calmodulin 3. (149 aa)
LOC112153035Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
tcf7l2Transcription factor 7 like 2. (628 aa)
fzd3Frizzled class receptor 3a; Belongs to the G-protein coupled receptor Fz/Smo family. (695 aa)
LOC112161708Uncharacterized protein. (839 aa)
ENSOMEP00000030778Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
kitMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (983 aa)
ENSOMEP00000031022KIT proto-oncogene, receptor tyrosine kinase b; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (909 aa)
CSDE1Cold shock domain containing E1, RNA-binding. (869 aa)
adcy7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1099 aa)
ctnnb1Catenin (cadherin-associated protein), beta 1. (783 aa)
LOC112146394Zgc:55558. (186 aa)
POMCProopiomelanocortin. (219 aa)
adcy5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1196 aa)
wnt10b-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (465 aa)
LOC112144558Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
ENSOMEP00000032467Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (539 aa)
ENSOMEP00000032569Adenylate cyclase 3b; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (357 aa)
prkacbUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
LOC112159026Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1179 aa)
LOC112156435Uncharacterized protein. (1276 aa)
wnt16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1105 aa)
ENSOMEP00000035988Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (553 aa)
wnt9bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
creb3l2cAMP responsive element binding protein 3-like 2. (536 aa)
Your Current Organism:
Oryzias melastigma
NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka
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