(45 nodes) Citrate cycle (TCA cycle) network (Aspergillus rambellii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	ARAM_006002	Citrate synthase; Belongs to the citrate synthase family. (460 aa)
	ARAM_002331	Uncharacterized protein. (485 aa)
	ARAM_000671	Lipoyl-binding domain-containing protein. (467 aa)
	ARAM_006657	Uncharacterized protein. (286 aa)
	ARAM_006805	Isochorismatase domain-containing protein. (183 aa)
	ARAM_003109	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit. (167 aa)
	ARAM_000644	Isocitrate dehydrogenase, NAD-dependent. (368 aa)
	ARAM_002332	ATP-citrate synthase subunit 1. (651 aa)
	ARAM_001418	Uncharacterized protein. (246 aa)
	ARAM_002364	Uncharacterized protein. (345 aa)
	ARAM_003771	Citrate synthase; Belongs to the citrate synthase family. (530 aa)
	ARAM_000713	Citrate synthase; Belongs to the citrate synthase family. (474 aa)
	ARAM_005954	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (274 aa)
	ARAM_003133	Malate dehydrogenase; Belongs to the LDH/MDH superfamily. (354 aa)
	ARAM_000514	Citrate synthase; Belongs to the citrate synthase family. (440 aa)
	ARAM_007003	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1193 aa)
	ARAM_002089	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (443 aa)
	ARAM_001247	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (376 aa)
	ARAM_005649	Transket_pyr domain-containing protein. (1055 aa)
	ARAM_007621	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (405 aa)
	ARAM_002848	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (329 aa)
	ARAM_007207	Succinyl-CoA synthetase beta subunit. (412 aa)
	ARAM_002296	MFS domain-containing protein. (586 aa)
	ARAM_002588	Iso_dh domain-containing protein. (357 aa)
	ARAM_004747	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (484 aa)
	ARAM_000515	MFS domain-containing protein. (513 aa)
	ARAM_006655	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (385 aa)
	ARAM_004923	Phosphoenolpyruvate carboxykinase AcuF. (601 aa)
	ARAM_005035	MFS domain-containing protein. (589 aa)
	ARAM_007630	Putative MFS multidrug resistance transporter. (554 aa)
	ARAM_005586	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (904 aa)
	ARAM_004745	Malate dehydrogenase. (339 aa)
	ARAM_005496	Peripheral subunit-binding (PSBD) domain-containing protein. (300 aa)
	ARAM_005172	Succinate dehydrogenase cytochrome b560 subunit. (188 aa)
	ARAM_003432	Bms1-type G domain-containing protein. (805 aa)
	ARAM_001631	Dihydrolipoyl dehydrogenase. (514 aa)
	ARAM_003668	Putative fumarate hydratase. (545 aa)
	ARAM_003206	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (505 aa)
	ARAM_006409	MFS domain-containing protein. (592 aa)
	ARAM_006534	Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer. (260 aa)
	ARAM_000812	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (783 aa)
	ARAM_002916	Putative MFS transporter. (509 aa)
	ARAM_006044	Uncharacterized protein. (177 aa)
	ARAM_004953	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (647 aa)
	ARAM_000309	WAPL domain-containing protein. (697 aa)

Your Current Organism:

Aspergillus rambellii

NCBI taxonomy Id: 308745
Other names: A. rambellii, ATCC 42001, CBS 101887, IBT 14580

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARAM_000309	ARAM_000514	A0A0F8XT83	A0A0F8V0S0	WAPL domain-containing protein.	Citrate synthase; Belongs to the citrate synthase family.	0.860
ARAM_000309	ARAM_000644	A0A0F8XT83	A0A0F8UMZ9	WAPL domain-containing protein.	Isocitrate dehydrogenase, NAD-dependent.	0.445
ARAM_000309	ARAM_000671	A0A0F8XT83	A0A0F8U7X5	WAPL domain-containing protein.	Lipoyl-binding domain-containing protein.	0.659
ARAM_000309	ARAM_000713	A0A0F8XT83	A0A0F8UZ33	WAPL domain-containing protein.	Citrate synthase; Belongs to the citrate synthase family.	0.860
ARAM_000309	ARAM_000812	A0A0F8XT83	A0A0F8X909	WAPL domain-containing protein.	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	0.545
ARAM_000309	ARAM_001247	A0A0F8XT83	A0A0F8V553	WAPL domain-containing protein.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.719
ARAM_000309	ARAM_001631	A0A0F8XT83	A0A0F8X452	WAPL domain-containing protein.	Dihydrolipoyl dehydrogenase.	0.827
ARAM_000309	ARAM_002089	A0A0F8XT83	A0A0F8V4A0	WAPL domain-containing protein.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.793
ARAM_000309	ARAM_002331	A0A0F8XT83	A0A0F8TYH9	WAPL domain-containing protein.	Uncharacterized protein.	0.777
ARAM_000309	ARAM_002332	A0A0F8XT83	A0A0F8UNJ3	WAPL domain-containing protein.	ATP-citrate synthase subunit 1.	0.777
ARAM_000309	ARAM_002364	A0A0F8XT83	A0A0F8UYB6	WAPL domain-containing protein.	Uncharacterized protein.	0.743
ARAM_000309	ARAM_002588	A0A0F8XT83	A0A0F8WAR3	WAPL domain-containing protein.	Iso_dh domain-containing protein.	0.445
ARAM_000309	ARAM_002848	A0A0F8XT83	A0A0F8VKI6	WAPL domain-containing protein.	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.867
ARAM_000309	ARAM_003109	A0A0F8XT83	A0A0F8ULH0	WAPL domain-containing protein.	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit.	0.471
ARAM_000309	ARAM_003206	A0A0F8XT83	A0A0F8X6H3	WAPL domain-containing protein.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.743
ARAM_000309	ARAM_003668	A0A0F8XT83	A0A0F8X4G0	WAPL domain-containing protein.	Putative fumarate hydratase.	0.826
ARAM_000309	ARAM_003771	A0A0F8XT83	A0A0F8UYW9	WAPL domain-containing protein.	Citrate synthase; Belongs to the citrate synthase family.	0.860
ARAM_000309	ARAM_004747	A0A0F8XT83	A0A0F8WEV6	WAPL domain-containing protein.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.517
ARAM_000309	ARAM_004953	A0A0F8XT83	A0A0F8XRV8	WAPL domain-containing protein.	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).	0.840
ARAM_000309	ARAM_005496	A0A0F8XT83	A0A0F8WZR9	WAPL domain-containing protein.	Peripheral subunit-binding (PSBD) domain-containing protein.	0.517