(76 nodes) Cysteine and methionine metabolism network (Aspergillus rambellii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

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gene co-occurrence

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textmining

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protein homology

Your Input:
	ARAM_006483	Putative isochorismatase family hydrolase. (422 aa)
	ARAM_007515	Putative acetyltransferase. (695 aa)
	ARAM_005376	Uncharacterized protein. (146 aa)
	ARAM_000659	Uncharacterized protein. (1258 aa)
	ARAM_004288	Phosphoserine aminotransferase. (424 aa)
	ARAM_006577	Putative glutamate-cysteine ligase Gcs1. (670 aa)
	MDE1	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). (243 aa)
	ARAM_000429	Aspartate-semialdehyde dehydrogenase. (363 aa)
	ARAM_002442	DUF895 domain membrane protein. (504 aa)
	ARAM_007141	NAD dependent epimerase/dehydratase family protein. (329 aa)
	ARAM_001077	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (866 aa)
	ARAM_003670	Aspartate aminotransferase. (394 aa)
	ARAM_005322	Putative Phosphoserine phosphatase. (250 aa)
	ARAM_004273	Putative thiosulfate sulfurtransferase. (344 aa)
	ARAM_005446	Aminotran_1_2 domain-containing protein. (516 aa)
	ARAM_006472	Aminotransferase, classes I and II. (473 aa)
	ARAM_004735	Cystathionine beta-lyase MetG. (434 aa)
	ARAM_006026	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (374 aa)
	ARAM_001534	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (536 aa)
	ARAM_004473	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (414 aa)
	ARAM_004664	MARVEL domain-containing protein. (284 aa)
	ARAM_001522	PALP domain-containing protein. (458 aa)
	ARAM_000661	Uncharacterized protein. (558 aa)
	ARAM_006489	Yae1_N domain-containing protein. (202 aa)
	ARAM_007412	Uncharacterized protein. (138 aa)
	ARAM_003133	Malate dehydrogenase; Belongs to the LDH/MDH superfamily. (354 aa)
	ARAM_003182	Uncharacterized protein. (296 aa)
	ARAM_005768	Glutathione synthetase. (500 aa)
	ARAM_003764	Rhamnogalacturonase. (586 aa)
	ARAM_005715	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (401 aa)
	ARAM_005425	Aminotran_1_2 domain-containing protein. (591 aa)
	ARAM_002928	Cysteine synthase. (368 aa)
	ARAM_004162	Cysteine dioxygenase. (236 aa)
	ARAM_000306	D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (474 aa)
	ARAM_007640	Uncharacterized protein. (266 aa)
	ARAM_001234	2,3-diketo-5-methylthio-1-phosphopentane phosphatase. (303 aa)
	ARAM_001620	Prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit alpha family. (198 aa)
	ARAM_001862	Meth_synt_2 domain-containing protein. (409 aa)
	ARAM_004710	Uncharacterized protein. (192 aa)
	ARAM_005554	Aminotran_1_2 domain-containing protein. (415 aa)
	ARAM_002218	rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (400 aa)
	ARAM_003911	Uncharacterized protein; Belongs to the LDH/MDH superfamily. (331 aa)
	ARAM_000471	PALP domain-containing protein. (412 aa)
	ARAM_004099	Putative 1-aminocyclopropane-1-carboxylate deaminase. (317 aa)
	ADI1	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (178 aa)
	ARAM_006239	Rhodanese domain-containing protein. (232 aa)
	ARAM_000715	O-acetylhomoserine (Thiol)-lyase. (431 aa)
	ARAM_007087	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (595 aa)
	MRI1	Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. (380 aa)
	ARAM_004524	Uncharacterized protein. (666 aa)
	ARAM_004522	Acetyltransferase, CysE/LacA/LpxA/NodL family. (210 aa)
	ARAM_002738	Homoserine dehydrogenase. (369 aa)
	ARAM_002316	Spermidine synthase; Belongs to the spermidine/spermine synthase family. (292 aa)
	ARAM_000344	Cobalamin-independent methionine synthase MetH/D. (774 aa)
	ARAM_005584	Adenosylhomocysteinase. (449 aa)
	ARAM_001809	Cystathionine gamma-lyase. (411 aa)
	ARAM_004745	Malate dehydrogenase. (339 aa)
	ARAM_001837	Uncharacterized protein. (645 aa)
	ARAM_003634	Uncharacterized protein. (229 aa)
	ARAM_002356	Zn(2)-C6 fungal-type domain-containing protein. (732 aa)
	ARAM_007177	Uncharacterized protein. (251 aa)
	ARAM_003541	Uncharacterized protein. (299 aa)
	ARAM_005914	Uncharacterized protein. (509 aa)
	ARAM_000975	Aspartate aminotransferase. (429 aa)
	ARAM_003217	Uncharacterized protein. (1443 aa)
	ARAM_007704	Aspartate aminotransferase. (168 aa)
	ARAM_002292	Uncharacterized protein. (271 aa)
	ARAM_004829	Hcy-binding domain-containing protein. (385 aa)
	ARAM_003976	Uncharacterized protein. (182 aa)
	ARAM_001053	Uncharacterized protein. (271 aa)
	ARAM_005942	PALP domain-containing protein. (371 aa)
	ARAM_003044	Uncharacterized protein. (1129 aa)
	ARAM_002960	Putative homoserine O-acetyltransferase. (481 aa)
	ARAM_000309	WAPL domain-containing protein. (697 aa)
	ARAM_000298	Aspartokinase. (525 aa)
	ARAM_000059	Aminotran_1_2 domain-containing protein. (312 aa)

Your Current Organism:

Aspergillus rambellii

NCBI taxonomy Id: 308745
Other names: A. rambellii, ATCC 42001, CBS 101887, IBT 14580

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADI1	ARAM_000059	A0A0F8W8L0	A0A0F8XU74	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	Aminotran_1_2 domain-containing protein.	0.545
ADI1	ARAM_000975	A0A0F8W8L0	A0A0F8X9G7	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	Aspartate aminotransferase.	0.545
ADI1	ARAM_001077	A0A0F8W8L0	A0A0F8UCW8	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	0.564
ADI1	ARAM_001234	A0A0F8W8L0	A0A0F8V536	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	2,3-diketo-5-methylthio-1-phosphopentane phosphatase.	0.960
ADI1	ARAM_001837	A0A0F8W8L0	A0A0F8X118	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	Uncharacterized protein.	0.631
ADI1	ARAM_002316	A0A0F8W8L0	A0A0F8WQE0	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	Spermidine synthase; Belongs to the spermidine/spermine synthase family.	0.526
ADI1	ARAM_003182	A0A0F8W8L0	A0A0F8V0F9	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	Uncharacterized protein.	0.590
ADI1	ARAM_003670	A0A0F8W8L0	A0A0F8UFT8	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	Aspartate aminotransferase.	0.545
ADI1	ARAM_004473	A0A0F8W8L0	A0A0F8UVA3	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.636
ADI1	ARAM_004829	A0A0F8W8L0	A0A0F8XHJ0	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	Hcy-binding domain-containing protein.	0.590
ADI1	ARAM_005322	A0A0F8W8L0	A0A0F8UHR6	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	Putative Phosphoserine phosphatase.	0.960
ADI1	ARAM_005554	A0A0F8W8L0	A0A0F8VGZ1	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	Aminotran_1_2 domain-containing protein.	0.714
ADI1	ARAM_005715	A0A0F8W8L0	A0A0F8V3S3	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.631
ADI1	ARAM_006026	A0A0F8W8L0	A0A0F8US50	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	0.475
ADI1	ARAM_006472	A0A0F8W8L0	A0A0F8UPY2	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	Aminotransferase, classes I and II.	0.714
ADI1	ARAM_007704	A0A0F8W8L0	A0A0F8XCE7	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	Aspartate aminotransferase.	0.545
ADI1	MDE1	A0A0F8W8L0	A0A0F8U8T9	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).	0.967
ADI1	MRI1	A0A0F8W8L0	A0A0F8WFD3	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.	0.723
ARAM_000059	ADI1	A0A0F8XU74	A0A0F8W8L0	Aminotran_1_2 domain-containing protein.	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	0.545
ARAM_000059	ARAM_000298	A0A0F8XU74	A0A0F8XT89	Aminotran_1_2 domain-containing protein.	Aspartokinase.	0.876