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HVO_0113 HVO_0113 HVO_0214 HVO_0214 glcK glcK citZ citZ gap1 gap1 pgk pgk gap2 gap2 azf azf citB2 citB2 dsa2 dsa2 fba2 fba2 aroB aroB pykA pykA ppsA ppsA korB korB korA korA acs1 acs1 acdA acdA gdh gdh acs3 acs3 tpiA1 tpiA1 porB porB porA porA fbp1 fbp1 fba1 fba1 HVO_1553 HVO_1553 acs5 acs5 HVO_1797 HVO_1797 citB1 citB1 pgi pgi tpiA2 tpiA2 HVO_2106 HVO_2106 aor4 aor4 oadhA4 oadhA4 maeB2 maeB2 sucD sucD sucC sucC pccB2 pccB2 HVO_2472 HVO_2472 bccA bccA gpmI gpmI icd icd ppc ppc eno eno sdhA sdhA sdhB sdhB sdhD sdhD sdhC sdhC fumC fumC oadhA1 oadhA1 oadhB1 oadhB1 dsa1 dsa1 lpdA lpdA serA3 serA3 mdh mdh
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
HVO_0113Putative phosphatase (histidine phosphatase family protein). (205 aa)
HVO_0214L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (320 aa)
glcKGlucokinase. (322 aa)
citZCitrate synthase; Might regulate the synthesis and function of enzymes involved in later enzymatic steps of Krebs cycle; Belongs to the citrate synthase family. (379 aa)
gap1Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating). (355 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (401 aa)
gap2Glyceraldehyde-3-phosphate dehydrogenase (NAD) (phosphorylating); Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (350 aa)
azfGlucose-6-phosphate 1-dehydrogenase (NAD); Catalyzes the NAD-dependent oxidation of glucose 6-phosphate to 6-phosphogluconolactone; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (262 aa)
citB2Aconitate hydratase. (938 aa)
dsa2Dihydrolipoamide S-acyltransferase. (495 aa)
fba22-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (266 aa)
aroB3-dehydroquinate synthase, type II; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. (392 aa)
pykAPyruvate kinase; Belongs to the pyruvate kinase family. (585 aa)
ppsAPhosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (761 aa)
korBOxoglutarate--ferredoxin oxidoreductase beta subunit. (287 aa)
korAOxoglutarate--ferredoxin oxidoreductase alpha subunit. (586 aa)
acs1acyl-CoA synthetase. (662 aa)
acdAacetate--CoA ligase (ADP-forming). (697 aa)
gdhGlucose 1-dehydrogenase; Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a modified Entner-Doudoroff pathway. (357 aa)
acs3acyl-CoA synthetase. (535 aa)
tpiA1Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (214 aa)
porBPyruvate--ferredoxin oxidoreductase beta subunit. (312 aa)
porAPyruvate--ferredoxin oxidoreductase alpha subunit. (631 aa)
fbp1Fructose-1,6-bisphosphatase. (297 aa)
fba1Fructose-bisphosphate aldolase, class 2; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. Is required for the utilization of fructose as a sole carbon and energy source. Plays a role in gluconeogenesis during growth on acetate, D-xylose, and casamino acids. (330 aa)
HVO_1553DUF4147 domain protein. (442 aa)
acs5acyl-CoA synthetase. (668 aa)
HVO_1797Beta-lactamase domain protein. (410 aa)
citB1Aconitate hydratase. (654 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (430 aa)
tpiA2Triosephosphate isomerase. (225 aa)
HVO_2106DeoC family aldolase. (258 aa)
aor4Aldehyde ferredoxin oxidoreductase. (643 aa)
oadhA4Putative branched-chain amino acid dehydrogenase E1 component alpha subunit. (348 aa)
maeB2Malate dehydrogenase (oxaloacetate-decarboxylating). (751 aa)
sucDsuccinate--CoA ligase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (289 aa)
sucCsuccinate--CoA ligase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (381 aa)
pccB2propionyl-CoA carboxylase carboxyltransferase component. (516 aa)
HVO_2472Uncharacterized protein. (89 aa)
bccApropionyl-CoA carboxylase biotin carboxylase component. (599 aa)
gpmIPhosphoglycerate mutase, 2,3-biphosphateglycerate-independent type; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (526 aa)
icdIsocitrate dehydrogenase (NADP); Belongs to the isocitrate and isopropylmalate dehydrogenases family. (419 aa)
ppcPhosphoenolpyruvate carboxylase. (897 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (399 aa)
sdhASuccinate dehydrogenase subunit A. (615 aa)
sdhBSuccinate dehydrogenase subunit B. (293 aa)
sdhDSuccinate dehydrogenase subunit D. (123 aa)
sdhCSuccinate dehydrogenase subunit C. (131 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (469 aa)
oadhA12-oxo-3-methylvalerate dehydrogenase E1 component alpha subunit. (368 aa)
oadhB12-oxo-3-methylvalerate dehydrogenase E1 component beta subunit. (327 aa)
dsa1Dihydrolipoamide S-acyltransferase. (521 aa)
lpdADihydrolipoyl dehydrogenase. (475 aa)
serA3D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (525 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. (304 aa)
Your Current Organism:
Haloferax volcanii
NCBI taxonomy Id: 309800
Other names: H. volcanii DS2, Haloferax volcanii ATCC 29605, Haloferax volcanii DS2, Haloferax volcanii DSM 3757, Haloferax volcanii str. DS2, Haloferax volcanii strain DS2
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