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| | lysC | Aspartate kinase; Belongs to the aspartokinase family. (392 aa) |
| | argF | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (299 aa) |
| | argE | Acetylornithine deacetylase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine. (381 aa) |
| | argD | Acetylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. (378 aa) |
| | argB | Acetylglutamate kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (327 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (347 aa) |
| | argX | Putative glutamate--argW ligase. (291 aa) |
| | argW | Putative biosynthetic carrier protein ArgW. (59 aa) |
| | argH | Argininosuccinate lyase. (488 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (405 aa) |
| | HVO_0112 | Tetratricopeptide repeat protein. (246 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (281 aa) |
| | ahcY | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (428 aa) |
| | ltaE | Threonine aldolase. (341 aa) |
| | speE | Polyamine aminopropyltransferase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. (537 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (312 aa) |
| | hom1 | Homoserine dehydrogenase. (317 aa) |
| | HVO_0419 | Peptidase M20 family protein (homolog to succinyl-diaminopimelate desuccinylase). (364 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphatase. (100 aa) |
| | hisH | Imidazoleglycerol-phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (219 aa) |
| | pheA | Prephenate dehydratase. (268 aa) |
| | ilvA1 | Threonine ammonia-lyase. (403 aa) |
| | thrC1 | Threonine synthase. (367 aa) |
| | cobD2 | L-threonine-O-3-phosphate decarboxylase. (337 aa) |
| | hom2 | Homoserine dehydrogenase. (316 aa) |
| | aroD2 | 3-dehydroquinate dehydratase. (222 aa) |
| | HVO_0608 | Oxidoreductase (homolog to zinc-containing alcohol dehydrogenase). (347 aa) |
| | leuA1 | 2-isopropylmalate synthase / (R)-citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (512 aa) |
| | pabC | Aminodeoxychorismate lyase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (330 aa) |
| | pabA | Aminodeoxychorismate synthase component 2. (239 aa) |
| | pabB | Aminodeoxychorismate synthase component 1. (504 aa) |
| | trpC | Indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (251 aa) |
| | trpB | Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (422 aa) |
| | trpA | Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. (277 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the decarboxylation of L-aspartate to produce beta- alanine; Belongs to the group II decarboxylase family. MfnA subfamily. (357 aa) |
| | thrC2 | Threonine synthase. (389 aa) |
| | HVO_0880 | Uncharacterized protein; COG 1340. (307 aa) |
| | aspC3 | Pyridoxal phosphate-dependent aminotransferase (probable aspartate aminotransferase). (384 aa) |
| | HVO_1021 | Putative carbon-nitrogen hydrolase. (254 aa) |
| | hisF | Imidazoleglycerol-phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (270 aa) |
| | HVO_1049 | PHP domain protein. (227 aa) |
| | asnB | Asparagine synthase (glutamine-hydrolyzing). (363 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase. (365 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (288 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (415 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase. (280 aa) |
| | dapB | 4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (253 aa) |
| | dapA | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (305 aa) |
| | cysS | cysteine--tRNA ligase. (494 aa) |
| | aldH2 | Aldehyde dehydrogenase. (508 aa) |
| | HVO_1294 | GMC family oxidoreductase. (526 aa) |
| | hisC | Histidinol-phosphate aminotransferase. (361 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (385 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (430 aa) |
| | tyrA | Prephenate dehydrogenase. (272 aa) |
| | aroQ | Chorismate mutase. (103 aa) |
| | HVO_1368 | Beta-lactamase domain protein. (267 aa) |
| | HVO_1369 | DUF124 family protein. (220 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (444 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (301 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (257 aa) |
| | cysK1 | Cysteine synthase. (326 aa) |
| | pyrI | Aspartate carbamoyltransferase regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (155 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (324 aa) |
| | leuD1 | 3-isopropylmalate dehydratase small subunit. (202 aa) |
| | leuC1 | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (473 aa) |
| | HVO_1505 | Uncharacterized protein. (87 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (348 aa) |
| | ilvN | Acetolactate synthase small subunit. (218 aa) |
| | ilvB1 | Acetolactate synthase large subunit. (587 aa) |
| | leuA2 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (440 aa) |
| | rocF | Arginase; Belongs to the arginase family. (299 aa) |
| | aspC1 | Pyridoxal phosphate-dependent aminotransferase (probable aspartate aminotransferase). (373 aa) |
| | cysK2 | Cysteine synthase. (306 aa) |
| | katG | Catalase-peroxidase; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (718 aa) |
| | HVO_1784 | Peptidase M20 family protein. (414 aa) |
| | pdaD | Pyruvoyl-dependent arginine decarboxylase. (157 aa) |
| | cysE | Serine O-acetyltransferase. (287 aa) |
| | HVO_2091 | Pyridoxal phosphate-dependent aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (441 aa) |
| | HVO_2114 | Homolog to 4-hydroxy-tetrahydrodipicolinate synthase. (311 aa) |
| | trpD2 | Putative phosphoribosyltransferase (homolog to anthranilate phosphoribosyltransferase). (360 aa) |
| | dhs1 | Deoxyhypusine synthase. (359 aa) |
| | speB | Agmatinase; Belongs to the arginase family. (271 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (293 aa) |
| | trpG | Anthranilate synthase component 2; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (204 aa) |
| | trpE | Anthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (524 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (221 aa) |
| | trpD1 | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (331 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase. (344 aa) |
| | ansA | Asparaginase family protein. (342 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (584 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (428 aa) |
| | metE1 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (methionine synthase II); Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown. (357 aa) |
| | metE2 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (methionine synthase II). (336 aa) |
| | metB1 | Cystathionine synthase/lyase (cystathionine gamma-synthase, cystathionine gamma-lyase, cystathionine beta-lyase). (386 aa) |
| | HVO_2871 | Pyridoxal phosphate-dependent aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (450 aa) |
| | metB2 | Cystathionine synthase/lyase (cystathionine gamma-synthase, cystathionine gamma-lyase, cystathionine beta-lyase). (401 aa) |
| | serB | Phosphoserine phosphatase. (215 aa) |
| | thrC3 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (419 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (197 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (238 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (122 aa) |
| | metY2 | O-acetylhomoserine aminocarboxypropyltransferase (methionine synthase). (431 aa) |
| | metX | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (415 aa) |
| | metY1 | O-acetylhomoserine aminocarboxypropyltransferase (methionine synthase). (439 aa) |
