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lysC lysC ltaE ltaE ilvE ilvE hom1 hom1 ilvA1 ilvA1 thrC1 thrC1 hom2 hom2 HVO_0608 HVO_0608 leuA1 leuA1 pabC pabC thrC2 thrC2 dapF dapF lysA lysA dapD dapD dapB dapB dapA dapA leuB leuB leuD1 leuD1 leuC1 leuC1 HVO_1505 HVO_1505 ilvC ilvC ilvN ilvN ilvB1 ilvB1 leuA2 leuA2 HVO_2114 HVO_2114 thrB thrB asd asd ilvD ilvD thrC3 thrC3
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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lysCAspartate kinase; Belongs to the aspartokinase family. (392 aa)
ltaEThreonine aldolase. (341 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (312 aa)
hom1Homoserine dehydrogenase. (317 aa)
ilvA1Threonine ammonia-lyase. (403 aa)
thrC1Threonine synthase. (367 aa)
hom2Homoserine dehydrogenase. (316 aa)
HVO_0608Oxidoreductase (homolog to zinc-containing alcohol dehydrogenase). (347 aa)
leuA12-isopropylmalate synthase / (R)-citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (512 aa)
pabCAminodeoxychorismate lyase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (330 aa)
thrC2Threonine synthase. (389 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (288 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (415 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase. (280 aa)
dapB4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (253 aa)
dapA4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (305 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (324 aa)
leuD13-isopropylmalate dehydratase small subunit. (202 aa)
leuC13-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (473 aa)
HVO_1505Uncharacterized protein. (87 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (348 aa)
ilvNAcetolactate synthase small subunit. (218 aa)
ilvB1Acetolactate synthase large subunit. (587 aa)
leuA22-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (440 aa)
HVO_2114Homolog to 4-hydroxy-tetrahydrodipicolinate synthase. (311 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (293 aa)
asdAspartate-semialdehyde dehydrogenase. (344 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (584 aa)
thrC3Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (419 aa)
Your Current Organism:
Haloferax volcanii
NCBI taxonomy Id: 309800
Other names: H. volcanii DS2, Haloferax volcanii ATCC 29605, Haloferax volcanii DS2, Haloferax volcanii DSM 3757, Haloferax volcanii str. DS2, Haloferax volcanii strain DS2
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