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suk suk HVO_2607 HVO_2607 HVO_2606 HVO_2606 ppk2 ppk2 gpmI gpmI adk1 adk1 cmk cmk citG citG pilB5 pilB5 cirB cirB nadK1 nadK1 HVO_2339 HVO_2339 thrB thrB HVO_2307 HVO_2307 HVO_2306 HVO_2306 HVO_2302 HVO_2302 tmk tmk ark2 ark2 HVO_2186 HVO_2186 HVO_2112 HVO_2112 HVO_2109 HVO_2109 tpiA2 tpiA2 HVO_2102 HVO_2102 HVO_2086 HVO_2086 HVO_2030 HVO_2030 HVO_2025 HVO_2025 pgi pgi HVO_1959 HVO_1959 HVO_1953 HVO_1953 HVO_1897 HVO_1897 kae1 kae1 pyrH pyrH thiL thiL HVO_1812 HVO_1812 HVO_1811 HVO_1811 HVO_0074 HVO_0074 HVO_0113 HVO_0113 coaE coaE rio1 rio1 HVO_0189 HVO_0189 HVO_0204 HVO_0204 prsA prsA HVO_0301 HVO_0301 ribK ribK glcK glcK gap1 gap1 pgk pgk gap2 gap2 kdgK1 kdgK1 htr15a htr15a rio2 rio2 HVO_0570 HVO_0570 HVO_0621 HVO_0621 HVO_0632 HVO_0632 HVO_0675 HVO_0675 pykA pykA ppsA ppsA HVO_0066 HVO_0066 ptfB ptfB ptsI ptsI ptfA ptfA pfkB pfkB glpK glpK dhaL dhaL dhaK dhaK HVO_1553 HVO_1553 HVO_1635 HVO_1635 ppk1 ppk1 HVO_1713 HVO_1713 argB argB ygfD ygfD pilB3 pilB3 HVO_1179 HVO_1179 aldH2 aldH2 HVO_1201 HVO_1201 flaI flaI cheA cheA adk2 adk2 HVO_1298 HVO_1298 tpiA1 tpiA1 aroK aroK HVO_1356 HVO_1356 proB proB HVO_1414 HVO_1414 HVO_1456 HVO_1456 galK galK fba1 fba1 htr15b htr15b lpdA lpdA mptE mptE tdk tdk prkA2 prkA2 prkA1 prkA1 HVO_2840 HVO_2840 udk udk eno eno HVO_2762 HVO_2762 mvk mvk ndk ndk thiM thiM thiD thiD HVO_2660 HVO_2660 HVO_2628 HVO_2628
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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sukSugar kinase. (305 aa)
HVO_2607PQQ repeat protein; Overlaps another CDS with the same product name. (406 aa)
HVO_2606PQQ repeat protein; Overlaps another CDS with the same product name. (437 aa)
ppk2Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family. (747 aa)
gpmIPhosphoglycerate mutase, 2,3-biphosphateglycerate-independent type; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (526 aa)
adk1Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (208 aa)
cmkCytidylate kinase. (192 aa)
citGtriphosphoribosyl-dephospho-CoA synthase. (286 aa)
pilB5Type IV pilus biogenesis complex ATPase subunit. (758 aa)
cirBKaiC-type circadian clock protein CirB. (395 aa)
nadK1Putative NAD kinase (polyphosphate/ATP); Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (273 aa)
HVO_2339Sensor box histidine kinase. (606 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (293 aa)
HVO_2307HAD superfamily hydrolase. (222 aa)
HVO_2306Receiver box response regulator. (248 aa)
HVO_2302UbiB family protein. (558 aa)
tmkThymidylate kinase. (197 aa)
ark2Adaptive-response sensory-kinase. (577 aa)
HVO_2186DICT domain protein. (277 aa)
HVO_2112DUF1537 family protein. (412 aa)
HVO_2109Homolog to xylulose kinase. (486 aa)
tpiA2Triosephosphate isomerase. (225 aa)
HVO_2102Phosphotransferase system component IIA. (153 aa)
HVO_2086Sensor box histidine kinase. (558 aa)
HVO_2030HTR-like protein. (652 aa)
HVO_2025Receiver/sensor box protein. (367 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (430 aa)
HVO_1959Histidine kinase. (294 aa)
HVO_195311-domain light and oxygen sensing his kinase, putative. (773 aa)
HVO_1897UPF0218 family protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (179 aa)
kae1KEOPS complex subunit Kae1/Bud32; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. (552 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (237 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (297 aa)
HVO_1812Uncharacterized protein. (375 aa)
HVO_1811Sensor box histidine kinase. (859 aa)
HVO_0074Polyphosphate kinase domain protein. (276 aa)
HVO_0113Putative phosphatase (histidine phosphatase family protein). (205 aa)
coaEPutative dephospho-CoA kinase. (189 aa)
rio1RIO-type serine/threonine protein kinase Rio1; Serine/threonine-protein kinase that is able to autophosphorylate as well as to phosphorylate proteasome subunit alpha 1 (PsmA1) in vitro. Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). (290 aa)
HVO_0189CobC/GpmA family phosphatase. (212 aa)
HVO_0204Sensor box histidine kinase. (788 aa)
prsARibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (283 aa)
HVO_0301Receiver/sensor box histidine kinase. (629 aa)
ribKRiboflavin kinase, CTP-dependent; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (237 aa)
glcKGlucokinase. (322 aa)
gap1Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating). (355 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (401 aa)
gap2Glyceraldehyde-3-phosphate dehydrogenase (NAD) (phosphorylating); Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (350 aa)
kdgK12-keto-3-deoxygluconate kinase / 2-keto-3-deoxygalactonate kinase. (320 aa)
htr15aTransducer protein Htr15. (556 aa)
rio2RIO-type serine/threonine protein kinase Rio2. (303 aa)
HVO_0570Histidine kinase. (351 aa)
HVO_0621Sensor box histidine kinase. (580 aa)
HVO_0632Sensor box histidine kinase. (858 aa)
HVO_0675Pantoate kinase. (277 aa)
pykAPyruvate kinase; Belongs to the pyruvate kinase family. (585 aa)
ppsAPhosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (761 aa)
HVO_0066PQQ repeat protein. (420 aa)
ptfBPhosphotransferase system component IIB, fructose-specific; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II PtfABC PTS system is involved in fructose transport. (158 aa)
ptsIPhosphotransferase system component I; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (565 aa)
ptfAPhosphotransferase system component IIA, fructose-specific; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II PtfABC PTS system is involved in fructose transport. (154 aa)
pfkB1-phosphofructokinase; 1-phosphofructokinase involved in the utilization of fructose as a sole carbon and energy source; Belongs to the carbohydrate kinase PfkB family. (305 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. It also catalyzes the phosphorylation of dihydroxyacetone (DHA). Involved, together with the DHA kinase DhaKLM, in the metabolism of DHA. (510 aa)
dhaLDihydroxyacetone kinase subunit DhaL. (232 aa)
dhaKDihydroxyacetone kinase subunit DhaK. (332 aa)
HVO_1553DUF4147 domain protein. (442 aa)
HVO_1635Uncharacterized protein. (207 aa)
ppk1Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family. (832 aa)
HVO_1713Receiver/sensor box histidine kinase. (692 aa)
argBAcetylglutamate kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (327 aa)
ygfDYgfD family GTPase. (372 aa)
pilB3Type IV pilus biogenesis complex ATPase subunit. (564 aa)
HVO_1179Homolog to NAD kinase. (354 aa)
aldH2Aldehyde dehydrogenase. (508 aa)
HVO_1201Sensor box histidine kinase. (708 aa)
flaIFlagellar motor/biogenesis protein FlaI. (554 aa)
cheATaxis sensor histidine kinase CheA. (756 aa)
adk2Putative adenylate kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (169 aa)
HVO_1298Sensor box histidine kinase. (472 aa)
tpiA1Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (214 aa)
aroKShikimate kinase, archaeal-type. (289 aa)
HVO_1356Sensor box histidine kinase. (550 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (301 aa)
HVO_1414Sensor box histidine kinase. (569 aa)
HVO_1456Receiver/sensor box histidine kinase. (506 aa)
galKGalactokinase. (405 aa)
fba1Fructose-bisphosphate aldolase, class 2; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. Is required for the utilization of fructose as a sole carbon and energy source. Plays a role in gluconeogenesis during growth on acetate, D-xylose, and casamino acids. (330 aa)
htr15bTransducer protein Htr15. (507 aa)
lpdADihydrolipoyl dehydrogenase. (475 aa)
mptE6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase MptE; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family. (227 aa)
tdkThymidine kinase. (195 aa)
prkA2Putative PrkA-type serine/threonine protein kinase. (690 aa)
prkA1Putative PrkA-type serine/threonine protein kinase. (757 aa)
HVO_2840Sensor box histidine kinase. (550 aa)
udkUridine kinase. (231 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (399 aa)
HVO_2762Isopentenyl phosphate kinase; Catalyzes the phosphorylation of isopentenyl phosphate (IP) to isopentenyl diphosphate (IPP). Functions in an alternate mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. (248 aa)
mvkMevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (367 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (154 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (298 aa)
thiDPhosphomethylpyrimidine kinase / phosphomethylpyrimidine phosphate kinase. (279 aa)
HVO_2660Receiver/sensor box histidine kinase. (629 aa)
HVO_2628GHMP family kinase (homolog to beta-ribofuranosylaminobenzene 5'-phosphate synthase); Catalyzes the condensation of 4-aminobenzoate (pABA) with 5- phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta- ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P). (320 aa)
Your Current Organism:
Haloferax volcanii
NCBI taxonomy Id: 309800
Other names: H. volcanii DS2, Haloferax volcanii ATCC 29605, Haloferax volcanii DS2, Haloferax volcanii DSM 3757, Haloferax volcanii str. DS2, Haloferax volcanii strain DS2
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