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| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (301 aa) |
| | tnaA | Tryptophanase. (448 aa) |
| | tssA2 | Thiosulfate sulfurtransferase. (258 aa) |
| | tssA1 | Thiosulfate sulfurtransferase; May be a sulfotransferase involved in the formation of thiosulfate. (286 aa) |
| | act1 | acyl-CoA thioester hydrolase. (164 aa) |
| | argF | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (299 aa) |
| | argE | Acetylornithine deacetylase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine. (381 aa) |
| | argD | Acetylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. (378 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (347 aa) |
| | argX | Putative glutamate--argW ligase. (291 aa) |
| | argW | Putative biosynthetic carrier protein ArgW. (59 aa) |
| | argH | Argininosuccinate lyase. (488 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (405 aa) |
| | glyS | glycine--tRNA ligase. (594 aa) |
| | panE | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (298 aa) |
| | hemD | uroporphyrinogen-III synthase. (247 aa) |
| | sufS1 | Cysteine desulfurase; Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Able to reassemble a removed [2Fe-2S] cluster of an apo-ferredoxin. Shows a selenocysteine lyase activity approximately 280-fold higher than its cysteine desulfurase activity. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily. (426 aa) |
| | HVO_0113 | Putative phosphatase (histidine phosphatase family protein). (205 aa) |
| | serA1 | Putative D-2-hydroxyacid dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (324 aa) |
| | tyrS | tyrosine--tRNA ligase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily. (328 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (281 aa) |
| | HVO_0189 | CobC/GpmA family phosphatase. (212 aa) |
| | alaS1 | alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (922 aa) |
| | guaAa2 | Glutamine amidotransferase (homolog to GMP synthase subunit A). (237 aa) |
| | acd1 | glutaryl-CoA dehydrogenase. (387 aa) |
| | HVO_0212 | Glyoxalase domain protein. (124 aa) |
| | HVO_0214 | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (320 aa) |
| | glnA | Glutamine synthetase; Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback- inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation. Under [...] (456 aa) |
| | ltaE | Threonine aldolase. (341 aa) |
| | etfA1 | Electron transfer flavoprotein alpha subunit. (317 aa) |
| | argS | arginine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (587 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (312 aa) |
| | fadM1 | Proline dehydrogenase. (279 aa) |
| | hom1 | Homoserine dehydrogenase. (317 aa) |
| | HVO_0419 | Peptidase M20 family protein (homolog to succinyl-diaminopimelate desuccinylase). (364 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphatase. (100 aa) |
| | pdxT | Pyridoxal 5'-phosphate synthase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (202 aa) |
| | HVO_0441 | Beta-lactamase domain protein. (208 aa) |
| | hisH | Imidazoleglycerol-phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (219 aa) |
| | pheA | Prephenate dehydratase. (268 aa) |
| | leuS | leucine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (958 aa) |
| | ala | Alanine dehydrogenase; Catalyzes the NAD(+)-dependent oxidative deamination of L- alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate; Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily. (331 aa) |
| | ilvA1 | Threonine ammonia-lyase. (403 aa) |
| | thrC1 | Threonine synthase. (367 aa) |
| | gap1 | Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating). (355 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (401 aa) |
| | gap2 | Glyceraldehyde-3-phosphate dehydrogenase (NAD) (phosphorylating); Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (350 aa) |
| | HVO_0483 | ATP-grasp fold protein. (290 aa) |
| | guaAa3 | Glutamine amidotransferase (homolog to GMP synthase subunit A). (215 aa) |
| | mptD | Dihydroneopterin aldolase, archaeal-type; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family. (113 aa) |
| | HVO_0586 | HAD superfamily hydrolase. (211 aa) |
| | cobD1 | L-threonine-O-3-phosphate decarboxylase. (340 aa) |
| | cobD2 | L-threonine-O-3-phosphate decarboxylase. (337 aa) |
| | hom2 | Homoserine dehydrogenase. (316 aa) |
| | aroD1 | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (247 aa) |
| | aroD2 | 3-dehydroquinate dehydratase. (222 aa) |
| | HVO_0608 | Oxidoreductase (homolog to zinc-containing alcohol dehydrogenase). (347 aa) |
| | HVO_0609 | Beta-lactamase domain protein. (215 aa) |
| | HVO_0613 | Beta-lactamase domain protein. (215 aa) |
| | leuA1 | 2-isopropylmalate synthase / (R)-citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (512 aa) |
| | guaAa1 | GMP synthase (glutamine-hydrolyzing) subunit A; Catalyzes the synthesis of GMP from XMP. (183 aa) |
| | dsa2 | Dihydrolipoamide S-acyltransferase. (495 aa) |
| | oadhB3 | 2-oxoacid dehydrogenase E1 component beta subunit. (336 aa) |
| | oadhA3 | 2-oxoacid dehydrogenase E1 component alpha subunit. (344 aa) |
| | aspS | aspartate--tRNA(Asp/Asn) ligase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn). (434 aa) |
| | HVO_0687 | M20 family amidohydrolase; Belongs to the peptidase M20A family. (444 aa) |
| | pabC | Aminodeoxychorismate lyase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (330 aa) |
| | pabB | Aminodeoxychorismate synthase component 1. (504 aa) |
| | aroE2 | Shikimate 5-dehydrogenase C-terminal domain protein. (157 aa) |
| | aroE1 | Shikimate 5-dehydrogenase N-terminal domain protein. (121 aa) |
| | dtdA | D-aminoacyl-tRNA deacylase; D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo. (439 aa) |
| | HVO_0771 | Beta-lactamase domain protein. (262 aa) |
| | trpC | Indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (251 aa) |
| | trpB | Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (422 aa) |
| | trpA | Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. (277 aa) |
| | fba2 | 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (266 aa) |
| | aroB | 3-dehydroquinate synthase, type II; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. (392 aa) |
| | pykA | Pyruvate kinase; Belongs to the pyruvate kinase family. (585 aa) |
| | metS | methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (740 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the decarboxylation of L-aspartate to produce beta- alanine; Belongs to the group II decarboxylase family. MfnA subfamily. (357 aa) |
| | ppsA | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (761 aa) |
| | thrC2 | Threonine synthase. (389 aa) |
| | mmcB | methylmalonyl-CoA mutase subunit B (cobalamin-binding subunit). (139 aa) |
| | acaB1 | acetyl-CoA C-acetyltransferase. (388 aa) |
| | HVO_0866 | Homolog to alanine-tRNA ligase. (244 aa) |
| | gltB | Glutamate synthase large subunit. (1511 aa) |
| | proS | proline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (488 aa) |
| | HVO_0880 | Uncharacterized protein; COG 1340. (307 aa) |
| | nosD | ABC-type transport system periplasmic substrate-binding protein (probable substrate copper). (641 aa) |
| | mmcA1 | methylmalonyl-CoA mutase subunit A. (566 aa) |
| | acs1 | acyl-CoA synthetase. (662 aa) |
| | HVO_0914 | Glyoxalase domain protein. (259 aa) |
| | fdhA | Formate dehydrogenase alpha subunit. (680 aa) |
| | aspC3 | Pyridoxal phosphate-dependent aminotransferase (probable aspartate aminotransferase). (384 aa) |
| | acaB2 | acetyl-CoA C-acetyltransferase catalytic subunit. (383 aa) |
| | HVO_1039 | Metallo-beta-lactamase superfamily protein. (167 aa) |
| | HVO_1041 | Beta-lactamase domain protein. (332 aa) |
| | hisF | Imidazoleglycerol-phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (270 aa) |
| | asnB | Asparagine synthase (glutamine-hydrolyzing). (363 aa) |
| | gatC | aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (92 aa) |
| | coaBC | Phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase. (386 aa) |
| | HVO_1073 | ThiJ/PfpI domain protein. (224 aa) |
| | folCP | Folylpolyglutamate synthase / 7,8-dihydropteroate reductase / dihydropteroate synthase; Can complement an H.volcanii mutant strain that is thymidine auxotroph because it lacks the two dihydrofolate reductase genes encoded by hdrA and hdrB; In the N-terminal section; belongs to the folylpolyglutamate synthase family. (838 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase. (365 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (288 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (415 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase. (280 aa) |
| | dapB | 4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (253 aa) |
| | dapA | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (305 aa) |
| | cysS | cysteine--tRNA ligase. (494 aa) |
| | acd2 | acyl-CoA dehydrogenase. (380 aa) |
| | aldH2 | Aldehyde dehydrogenase. (508 aa) |
| | fadM2 | Proline dehydrogenase. (279 aa) |
| | acd3 | acyl-CoA dehydrogenase. (380 aa) |
| | acs3 | acyl-CoA synthetase. (535 aa) |
| | hdrA | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis; Belongs to the dihydrofolate reductase family. (162 aa) |
| | HVO_1291 | Fumarylacetoacetase family protein. (243 aa) |
| | hisC | Histidinol-phosphate aminotransferase. (361 aa) |
| | tpiA1 | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (214 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (385 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (430 aa) |
| | tyrA | Prephenate dehydrogenase. (272 aa) |
| | aroQ | Chorismate mutase. (103 aa) |
| | aroK | Shikimate kinase, archaeal-type. (289 aa) |
| | HVO_1368 | Beta-lactamase domain protein. (267 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (444 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (257 aa) |
| | acd4 | acyl-CoA dehydrogenase. (383 aa) |
| | acs4 | acyl-CoA synthetase. (553 aa) |
| | mmcA2 | methylmalonyl-CoA mutase subunit A. (558 aa) |
| | fadA1 | enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (257 aa) |
| | HVO_1395 | M20 family amidohydrolase (homolog to indole-3-acetyl-aspartate hydrolase). (427 aa) |
| | HVO_1415 | HAD superfamily hydrolase. (230 aa) |
| | cysK1 | Cysteine synthase. (326 aa) |
| | hbd3 | 3-hydroxyacyl-CoA dehydrogenase. (286 aa) |
| | pccB1 | propionyl-CoA carboxylase carboxyltransferase component. (581 aa) |
| | maoC1 | MaoC domain protein. (156 aa) |
| | gdhA1 | Glutamate dehydrogenase (NAD); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (428 aa) |
| | citE | Homolog to citrate lyase beta subunit. (279 aa) |
| | gdhA2 | Glutamate dehydrogenase (NADP); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (417 aa) |
| | pyrB | Aspartate carbamoyltransferase catalytic subunit. (304 aa) |
| | fadA2 | enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (269 aa) |
| | menF | Isochorismate synthase. (443 aa) |
| | gnaD | D-gluconate dehydratase; NADP-dependent D-xylose dehydrogenase involved in the degradation of D-xylose, a major component of hemicelluloses such as xylan. Catalyzes the third reaction in the xylose utilization pathway through dehydratation of D-xylonate into 2-dehydro-3-deoxy-D-xylonate. (412 aa) |
| | fba1 | Fructose-bisphosphate aldolase, class 2; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. Is required for the utilization of fructose as a sole carbon and energy source. Plays a role in gluconeogenesis during growth on acetate, D-xylose, and casamino acids. (330 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (324 aa) |
| | leuD1 | 3-isopropylmalate dehydratase small subunit. (202 aa) |
| | leuC1 | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (473 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (348 aa) |
| | ilvN | Acetolactate synthase small subunit. (218 aa) |
| | leuA2 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (440 aa) |
| | aglM | UDP-glucose 6-dehydrogenase AglM; Involved in the assembly of a N-linked pentasaccharide that decorates the S-layer glycoprotein and flagellins. Involved in the biosynthesis of the hexuronic acids found at both positions 2 and 3 of the pentasaccharide; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (430 aa) |
| | ileS | isoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1043 aa) |
| | act2 | acyl-CoA thioester hydrolase. (160 aa) |
| | aspC1 | Pyridoxal phosphate-dependent aminotransferase (probable aspartate aminotransferase). (373 aa) |
| | cysK2 | Cysteine synthase. (306 aa) |
| | thrS | threonine--tRNA ligase; Belongs to the class-II aminoacyl-tRNA synthetase family. (643 aa) |
| | HVO_1693 | DUF162 family protein. (167 aa) |
| | HVO_1697 | FAD-dependent oxidoreductase (GlcD/DLD_GlcF/GlpC domain fusion protein). (1026 aa) |
| | HVO_1699 | Aminotransferase; Pyridoxal phosphate-dependent aminotransferase (homolog to histidinol-phosphate aminotransferase / aspartate aminotransferase). (378 aa) |
| | HVO_1784 | Peptidase M20 family protein. (414 aa) |
| | gndA | 6-phosphogluconate dehydrogenase (NAD-dependent, decarboxylating); Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NAD to NADH. (299 aa) |
| | hisS | histidine--tRNA ligase; Belongs to the class-II aminoacyl-tRNA synthetase family. (431 aa) |
| | lysS | lysine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (555 aa) |
| | HVO_1875 | O-acetyltransferase (homolog to galactoside O-acetyltransferase). (305 aa) |
| | fadA3 | enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (231 aa) |
| | HVO_1905 | Beta-lactamase domain protein. (274 aa) |
| | acaB3 | acetyl-CoA C-acyltransferase. (377 aa) |
| | acs6 | acyl-CoA synthetase. (666 aa) |
| | serS | serine--tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (460 aa) |
| | ddh | 2-D-hydroxyacid dehydrogenase. (308 aa) |
| | cofE | Coenzyme F420:L-glutamate ligase; Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8- didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420- 0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives. (251 aa) |
| | pdaD | Pyruvoyl-dependent arginine decarboxylase. (157 aa) |
| | pgi | Glucose-6-phosphate isomerase; Belongs to the GPI family. (430 aa) |
| | aceB1 | Malate synthase; Involved in the glyoxylate cycle which synthesizes precursors for carbohydrates from C2 compounds such as acetate. Catalyzes the Claisen condensation between acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form the malyl-CoA intermediate that is subsequently hydrolyzed to produce malate and CoA. (433 aa) |
| | aceA | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. (345 aa) |
| | cysE | Serine O-acetyltransferase. (287 aa) |
| | HVO_2091 | Pyridoxal phosphate-dependent aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (441 aa) |
| | tpiA2 | Triosephosphate isomerase. (225 aa) |
| | HVO_2106 | DeoC family aldolase. (258 aa) |
| | HVO_2114 | Homolog to 4-hydroxy-tetrahydrodipicolinate synthase. (311 aa) |
| | HVO_2127 | M20 family amidohydrolase (homolog to indole-3-acetyl-aspartate hydrolase). (420 aa) |
| | amaB1 | Amidase (hydantoinase/carbamoylase family). (418 aa) |
| | maeB1 | Malic enzyme (NADP). (751 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase subunit PurQ; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (224 aa) |
| | cofC | 2-phospho-L-lactate guanylyltransferase; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. (206 aa) |
| | oadhA4 | Putative branched-chain amino acid dehydrogenase E1 component alpha subunit. (348 aa) |
| | trpD2 | Putative phosphoribosyltransferase (homolog to anthranilate phosphoribosyltransferase). (360 aa) |
| | HVO_2244 | Fumarylacetoacetase family protein. (239 aa) |
| | speB | Agmatinase; Belongs to the arginase family. (271 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (293 aa) |
| | HVO_2360 | Peptidase S66 family protein. (340 aa) |
| | carB | Carbamoyl-phosphate synthase (glutamine-hydrolyzing) large subunit; Belongs to the CarB family. (1082 aa) |
| | HVO_2370 | HAD superfamily hydrolase. (219 aa) |
| | hadL | Haloacid dehalogenase, type II. (234 aa) |
| | gcvP2 | Glycine cleavage system protein P beta subunit. (473 aa) |
| | gcvP1 | Glycine cleavage system protein P alpha subunit. (447 aa) |
| | gcvH | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa) |
| | gcvT | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (363 aa) |
| | maeB2 | Malate dehydrogenase (oxaloacetate-decarboxylating). (751 aa) |
| | trpG | Anthranilate synthase component 2; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (204 aa) |
| | trpE | Anthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (524 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (221 aa) |
| | trpD1 | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (331 aa) |
| | pccB2 | propionyl-CoA carboxylase carboxyltransferase component. (516 aa) |
| | cofD | 2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. (330 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase. (344 aa) |
| | kynU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (425 aa) |
| | carA | Carbamoyl-phosphate synthase (glutamine-hydrolyzing) small subunit; Belongs to the CarA family. (360 aa) |
| | gatD | glutamyl-tRNA(Gln) amidotransferase subunit D; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (415 aa) |
| | gpmI | Phosphoglycerate mutase, 2,3-biphosphateglycerate-independent type; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (526 aa) |
| | nadC | Nicotinate-nucleotide pyrophosphorylase (carboxylating); Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (268 aa) |
| | nadA | Quinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (385 aa) |
| | HVO_2582 | Metal dependent amidohydrolase M38 superfamily protein. (193 aa) |
| | icd | Isocitrate dehydrogenase (NADP); Belongs to the isocitrate and isopropylmalate dehydrogenases family. (419 aa) |
| | oadhA2 | 2-oxoacid dehydrogenase E1 component alpha subunit. (353 aa) |
| | oadhB2 | 2-oxoacid dehydrogenase E1 component beta subunit. (346 aa) |
| | ppc | Phosphoenolpyruvate carboxylase. (897 aa) |
| | maa | Maltose O-acetyltransferase. (185 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (549 aa) |
| | HVO_2638 | Homolog to dipeptide epimerase. (345 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (584 aa) |
| | serA2 | Putative D-2-hydroxyacid dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (319 aa) |
| | HVO_2661 | Aminotransferase class V (serine--pyruvate aminotransferase / alanine--glyoxylate aminotransferase). (370 aa) |
| | HVO_2665 | HpcH/HpaI aldolase family protein. (265 aa) |
| | HVO_2671 | Aminotransferase class V (serine--pyruvate aminotransferase / alanine--glyoxylate aminotransferase). (395 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (428 aa) |
| | panB2 | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (269 aa) |
| | tif2Bd | Translation initiation factor aIF-2B delta subunit; Belongs to the eIF-2B alpha/beta/delta subunits family. (282 aa) |
| | acd5 | acyl-CoA dehydrogenase. (381 aa) |
| | alaS2 | alanine--tRNA ligase. (398 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (493 aa) |
| | gltS | glutamate--tRNA(Glu/Gln) ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (585 aa) |
| | HVO_2727 | Cyclase family protein. (219 aa) |
| | etfA2 | Electron transfer flavoprotein alpha subunit. (582 aa) |
| | metE1 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (methionine synthase II); Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown. (357 aa) |
| | metE2 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (methionine synthase II). (336 aa) |
| | metB1 | Cystathionine synthase/lyase (cystathionine gamma-synthase, cystathionine gamma-lyase, cystathionine beta-lyase). (386 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (399 aa) |
| | hbd1 | 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (661 aa) |
| | glyA1 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (297 aa) |
| | HVO_2871 | Pyridoxal phosphate-dependent aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (450 aa) |
| | HVO_2879 | Homolog to ornithine cyclodeaminase. (332 aa) |
| | fumC | Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (469 aa) |
| | maoC3 | MaoC domain protein. (153 aa) |
| | folP2 | Dihydropteroate synthase. (379 aa) |
| | mptE | 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase MptE; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family. (227 aa) |
| | HVO_2917 | Beta-lactamase domain protein. (192 aa) |
| | hdrB | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. (194 aa) |
| | HVO_2926 | Metal-dependent amidohydrolase M38 superfamily protein. (253 aa) |
| | valS | valine--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. (870 aa) |
| | metB2 | Cystathionine synthase/lyase (cystathionine gamma-synthase, cystathionine gamma-lyase, cystathionine beta-lyase). (401 aa) |
| | pheT | phenylalanine--tRNA ligase beta subunit. (570 aa) |
| | pheS | phenylalanine--tRNA ligase alpha subunit. (499 aa) |
| | ocd3 | Ornithine cyclodeaminase. (349 aa) |
| | trpS1 | tryptophan--tRNA ligase; Catalyzes the attachment of tryptophan to tRNA(Trp). (529 aa) |
| | lipA | Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (311 aa) |
| | oadhA1 | 2-oxo-3-methylvalerate dehydrogenase E1 component alpha subunit. (368 aa) |
| | oadhB1 | 2-oxo-3-methylvalerate dehydrogenase E1 component beta subunit. (327 aa) |
| | lpdA | Dihydrolipoyl dehydrogenase. (475 aa) |
| | serB | Phosphoserine phosphatase. (215 aa) |
| | thrC3 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (419 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (197 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (238 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (122 aa) |
| | metY2 | O-acetylhomoserine aminocarboxypropyltransferase (methionine synthase). (431 aa) |
| | metX | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (415 aa) |
| | metY1 | O-acetylhomoserine aminocarboxypropyltransferase (methionine synthase). (439 aa) |
| | mdh | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. (304 aa) |
