STRINGSTRING
ilvD ilvD argH argH ilvA-2 ilvA-2 SRU_2330 SRU_2330 nth nth SRU_2363 SRU_2363 pckA-2 pckA-2 thrC thrC SRU_2431 SRU_2431 SRU_2433 SRU_2433 SRU_2533 SRU_2533 mltG mltG hemH-2 hemH-2 menB menB hemD hemD SRU_2793 SRU_2793 aroB aroB ribBA ribBA SRU_0020 SRU_0020 coaBC coaBC murQ murQ ppc ppc SRU_0253 SRU_0253 tal-2 tal-2 purB purB mutM mutM cysD cysD aroQ aroQ nnr nnr SRU_0509 SRU_0509 rfbB rfbB SRU_0717 SRU_0717 hutH hutH SRU_0737 SRU_0737 folB folB eno eno SRU_0837 SRU_0837 psd psd SRU_1012 SRU_1012 hemB hemB dapA dapA phrB phrB SRU_1161 SRU_1161 moaC moaC phrB-2 phrB-2 SRU_1227 SRU_1227 SRU_1231 SRU_1231 SRU_1258 SRU_1258 ilvA ilvA SRU_1328 SRU_1328 menC menC SRU_1368 SRU_1368 panD panD ybjU ybjU SRU_1431 SRU_1431 SRU_1435 SRU_1435 SRU_1447 SRU_1447 SRU_1477 SRU_1477 SRU_1508 SRU_1508 hisB hisB hisH hisH hisF hisF SRU_1567 SRU_1567 fumC fumC purK purK mqnA mqnA ispF ispF trpE trpE trpC trpC trpB trpB trpA trpA SRU_1685 SRU_1685 hemE hemE tnaA tnaA pyrF pyrF hemH hemH phrB-3 phrB-3 pckA pckA SRU_1841 SRU_1841 acnA acnA SRU_1878 SRU_1878 SRU_1906 SRU_1906 tal-3 tal-3 dacA dacA pheA pheA lacD lacD SRU_2038 SRU_2038 aroC aroC leuC leuC leuD leuD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ilvDDihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family. (612 aa)
argHArgininosuccinate lyase; Identified by match to protein family HMM PF00206; match to protein family HMM TIGR00838. (437 aa)
ilvA-2Threonine dehydratase; Identified by match to protein family HMM PF00291; match to protein family HMM PF01842; match to protein family HMM TIGR01127. (470 aa)
SRU_2330Deoxyribodipyrimidine photolyase, putative; Identified by match to protein family HMM PF00875; match to protein family HMM PF03441; Belongs to the DNA photolyase family. (537 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (324 aa)
SRU_2363Cys/Met metabolism PLP-dependent enzyme superfamily; Identified by match to protein family HMM PF01053. (412 aa)
pckA-2Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (530 aa)
thrCThreonine synthase; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR00260. (438 aa)
SRU_2431Peptidyl-prolyl cis-trans isomerase, cyclophilin-type domain protein; Identified by match to protein family HMM PF00160; match to protein family HMM PF02985; match to protein family HMM PF03130. (706 aa)
SRU_2433Metal-activated pyridoxal enzyme; Identified by match to protein family HMM PF01168. (388 aa)
SRU_2533Probable secreted glycosyl hydrolase; Identified by match to protein family HMM PF06439. (222 aa)
mltGUncharacterized BCR, YceG family COG1559; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (386 aa)
hemH-2Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (394 aa)
menBNaphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily. (297 aa)
hemDuroporphyrinogen-III synthase; Identified by match to protein family HMM PF02602. (262 aa)
SRU_2793Putative 6-pyruvoyl tetrahydropterin synthase; Identified by match to protein family HMM PF01242. (137 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (367 aa)
ribBA3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family. (415 aa)
SRU_0020Phosphosulfolactate synthase; Identified by match to protein family HMM PF02679. (273 aa)
coaBCPhosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (413 aa)
murQConserved hypothetical protein; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (311 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (957 aa)
SRU_0253PBS lyase HEAT-like repeat domain protein; Identified by match to protein family HMM PF03130. (374 aa)
tal-2Transaldolase, putative; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (226 aa)
purBAdenylosuccinate lyase; Identified by match to protein family HMM PF00206; match to protein family HMM TIGR00928; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (470 aa)
mutMformamidopyrimidine-DNA glycosylase; Identified by similarity to SP:O34403; match to protein family HMM PF01149; match to protein family HMM PF06831. (265 aa)
cysDO-acetylhomoserine sulfhydrylase; Identified by match to protein family HMM PF01053; match to protein family HMM PF01212; match to protein family HMM TIGR01326. (470 aa)
aroQ3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (142 aa)
nnrPredicted sugar kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity). In the N-terminal section; belongs to the NnrE/AIBP family. (542 aa)
SRU_0509Conserved hypothetical protein. (137 aa)
rfbBdTDP-glucose 4,6-dehydratase; Identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01181; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (342 aa)
SRU_0717Phenylalanine and histidine ammonia-lyase; Identified by match to protein family HMM PF00221. (517 aa)
hutHHistidine ammonia-lyase; Identified by match to protein family HMM PF00221; match to protein family HMM TIGR01225. (497 aa)
SRU_0737Hypothetical protein; Identified by Glimmer2; putative. (379 aa)
folBDihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (142 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa)
SRU_0837Tyrosine decarboxylase, putative; Identified by match to protein family HMM PF00282. (842 aa)
psdPhosphatidylserine decarboxylase-like protein; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (227 aa)
SRU_1012Conserved hypothetical protein. (172 aa)
hemBDelta-aminolevulinic acid dehydratase; Identified by match to protein family HMM PF00490; Belongs to the ALAD family. (340 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (302 aa)
phrBDeoxyribodipyrimidine photolyase; Identified by similarity to SP:P05327; match to protein family HMM PF00875; match to protein family HMM PF03441; Belongs to the DNA photolyase family. (463 aa)
SRU_1161Cystathionine beta-lyase MetC; Identified by match to protein family HMM PF01053; match to protein family HMM PF01212. (408 aa)
moaCMolybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (170 aa)
phrB-2Deoxyribodipyrimidine photolyase; Identified by similarity to SP:P05327; match to protein family HMM PF00875; match to protein family HMM PF03441; Belongs to the DNA photolyase family. (483 aa)
SRU_1227Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. (367 aa)
SRU_1231Pyridoxal-dependent decarboxylase family protein, putative; Identified by match to protein family HMM PF00282; match to protein family HMM PF01212. (470 aa)
SRU_1258L-2,4-diaminobutyrate decarboxylase; Identified by match to protein family HMM PF00282; match to protein family HMM PF01212. (518 aa)
ilvAThreonine dehydratase; Identified by match to protein family HMM PF00291. (331 aa)
SRU_1328Conserved hypothetical protein; Identified by similarity to GB:AAR35562.1. (389 aa)
menCO-succinylbenzoic acid (OSB) synthetase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). (366 aa)
SRU_1368Cystathionine beta-lyase MetC; Identified by match to protein family HMM PF01053; match to protein family HMM PF01212. (382 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (146 aa)
ybjUL-allo-threonine aldolase; Identified by match to protein family HMM PF00155; match to protein family HMM PF01212. (348 aa)
SRU_1431Conserved hypothetical protein. (304 aa)
SRU_1435Putative dihydrodipicolinate synthase; Identified by match to protein family HMM PF00701. (312 aa)
SRU_1447Putative pterin-4-alpha-carbinolamine dehydratase; Identified by match to protein family HMM PF01329. (128 aa)
SRU_1477Aconitate hydratase, putative; Identified by match to protein family HMM PF00330; match to protein family HMM PF00694; match to protein family HMM TIGR01342. (658 aa)
SRU_1508Conserved hypothetical protein. (123 aa)
hisBImidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. (202 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (218 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (268 aa)
SRU_1567Conserved hypothetical protein. (171 aa)
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (601 aa)
purKPhosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (379 aa)
mqnAHypothetical protein; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (271 aa)
ispF2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (157 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (523 aa)
trpCIndole-3-glycerol phosphate synthase; Identified by match to protein family HMM PF00218; Belongs to the TrpC family. (270 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (406 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (278 aa)
SRU_1685Chorismate binding enzyme; Identified by match to protein family HMM PF00425; match to protein family HMM TIGR00553. (615 aa)
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (354 aa)
tnaABeta-eliminating lyase; Identified by match to protein family HMM PF01212; Belongs to the beta-eliminating lyase family. (471 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Identified by match to protein family HMM PF00215; match to protein family HMM TIGR02127; Belongs to the OMP decarboxylase family. Type 2 subfamily. (331 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (447 aa)
phrB-3Deoxyribodipyrimidine photolyase; Identified by similarity to SP:P12769; match to protein family HMM PF00875; match to protein family HMM PF03441. (462 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (535 aa)
SRU_1841Conserved hypothetical protein TIGR00149; Identified by match to protein family HMM PF01894; match to protein family HMM TIGR00149. (139 aa)
acnAAconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (910 aa)
SRU_1878Conserved hypothetical protein. (142 aa)
SRU_1906Deoxyribose-phosphate aldolase family; Identified by match to protein family HMM PF01791. (437 aa)
tal-3Transaldolase, putative; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (224 aa)
dacAConserved hypothetical protein TIGR00159; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (266 aa)
pheAPrephenate dehydratase; Identified by match to protein family HMM PF00800; match to protein family HMM PF01842. (286 aa)
lacDTagatose 1,6-diphosphate aldolase; Identified by match to protein family HMM PF04274. (352 aa)
SRU_2038Deoxyribodipyrimidine photolyase-related protein; Identified by match to protein family HMM PF04244. (514 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (404 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (472 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (205 aa)
Your Current Organism:
Salinibacter ruber
NCBI taxonomy Id: 309807
Other names: S. ruber DSM 13855, Salinibacter ruber DSM 13855, Salinibacter ruber str. DSM 13855, Salinibacter ruber strain DSM 13855
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.