(28 nodes) Cysteine and methionine metabolism network (Salinibacter ruber)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	SRU_0301	Diaminopimelate decarboxylase; Identified by match to protein family HMM PF00278; match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM PF02784; match to protein family HMM TIGR00657; match to protein family HMM TIGR01048; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (870 aa)
	cysD	O-acetylhomoserine sulfhydrylase; Identified by match to protein family HMM PF01053; match to protein family HMM PF01212; match to protein family HMM TIGR01326. (470 aa)
	metX	Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (352 aa)
	lysC	Aspartate kinase; Identified by match to protein family HMM PF00696; Belongs to the aspartokinase family. (317 aa)
	SRU_0482	Bifunctional aspartokinase/homoserine dehydrogenase I; Identified by match to protein family HMM PF00742; match to protein family HMM PF03447. (374 aa)
	ldh	L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (316 aa)
	ThrA	Bifunctional aspartokinase/homoserine dehydrogenase I; Identified by match to protein family HMM PF00696; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447; match to protein family HMM TIGR00657. (821 aa)
	SRU_0697	GAF domain protein; Identified by match to protein family HMM PF01590. (170 aa)
	SRU_0922	Truncated methionine synthase-like protein; Identified by match to protein family HMM PF01717. (356 aa)
	SRU_0938	Aspartate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM PF01212. (404 aa)
	SRU_0989	Rhodanese-like domain protein; Identified by match to protein family HMM PF00581. (328 aa)
	SRU_1123	Cystathionine beta-synthase; Identified by match to protein family HMM PF00291; match to protein family HMM PF00571; match to protein family HMM TIGR01137. (505 aa)
	ahcY	Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (425 aa)
	SRU_1161	Cystathionine beta-lyase MetC; Identified by match to protein family HMM PF01053; match to protein family HMM PF01212. (408 aa)
	metE	5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (769 aa)
	SRU_1368	Cystathionine beta-lyase MetC; Identified by match to protein family HMM PF01053; match to protein family HMM PF01212. (382 aa)
	mtnN	MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (276 aa)
	mdh	Malate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (314 aa)
	lysC-2	Aspartate kinase; Identified by match to protein family HMM PF00696; Belongs to the aspartokinase family. (310 aa)
	asd	Aspartate-semialdehyde dehydrogenase; Identified by match to protein family HMM PF01118; match to protein family HMM PF02774; match to protein family HMM TIGR00978; Belongs to the aspartate-semialdehyde dehydrogenase family. (363 aa)
	SRU_2039	Cysteine synthase B; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136. (317 aa)
	SRU_2095	Mta/Sah nucleosidase (P46) [includes: 5'-methylthioadenosine nucleosidase and S-adenosylhomocysteine nucleosidase], putative. (203 aa)
	mtap	5'-methylthioadenosine phosphorylase II; Identified by match to protein family HMM PF00896. (263 aa)
	serC	Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (369 aa)
	ilvE	Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (313 aa)
	SRU_2363	Cys/Met metabolism PLP-dependent enzyme superfamily; Identified by match to protein family HMM PF01053. (412 aa)
	metK	S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (386 aa)
	SRU_2787	Cysteine synthase B; Identified by match to protein family HMM PF00291. (466 aa)

Your Current Organism:

Salinibacter ruber

NCBI taxonomy Id: 309807
Other names: S. ruber DSM 13855, Salinibacter ruber DSM 13855, Salinibacter ruber str. DSM 13855, Salinibacter ruber strain DSM 13855

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SRU_0301	SRU_0482	SRU_0301	SRU_0482	Diaminopimelate decarboxylase; Identified by match to protein family HMM PF00278; match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM PF02784; match to protein family HMM TIGR00657; match to protein family HMM TIGR01048; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	Bifunctional aspartokinase/homoserine dehydrogenase I; Identified by match to protein family HMM PF00742; match to protein family HMM PF03447.	0.899
SRU_0301	SRU_0922	SRU_0301	SRU_0922	Diaminopimelate decarboxylase; Identified by match to protein family HMM PF00278; match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM PF02784; match to protein family HMM TIGR00657; match to protein family HMM TIGR01048; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	Truncated methionine synthase-like protein; Identified by match to protein family HMM PF01717.	0.457
SRU_0301	SRU_0938	SRU_0301	SRU_0938	Diaminopimelate decarboxylase; Identified by match to protein family HMM PF00278; match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM PF02784; match to protein family HMM TIGR00657; match to protein family HMM TIGR01048; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	Aspartate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM PF01212.	0.944
SRU_0301	SRU_1123	SRU_0301	SRU_1123	Diaminopimelate decarboxylase; Identified by match to protein family HMM PF00278; match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM PF02784; match to protein family HMM TIGR00657; match to protein family HMM TIGR01048; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	Cystathionine beta-synthase; Identified by match to protein family HMM PF00291; match to protein family HMM PF00571; match to protein family HMM TIGR01137.	0.487
SRU_0301	SRU_1161	SRU_0301	SRU_1161	Diaminopimelate decarboxylase; Identified by match to protein family HMM PF00278; match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM PF02784; match to protein family HMM TIGR00657; match to protein family HMM TIGR01048; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	Cystathionine beta-lyase MetC; Identified by match to protein family HMM PF01053; match to protein family HMM PF01212.	0.567
SRU_0301	SRU_1368	SRU_0301	SRU_1368	Diaminopimelate decarboxylase; Identified by match to protein family HMM PF00278; match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM PF02784; match to protein family HMM TIGR00657; match to protein family HMM TIGR01048; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	Cystathionine beta-lyase MetC; Identified by match to protein family HMM PF01053; match to protein family HMM PF01212.	0.567
SRU_0301	SRU_2039	SRU_0301	SRU_2039	Diaminopimelate decarboxylase; Identified by match to protein family HMM PF00278; match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM PF02784; match to protein family HMM TIGR00657; match to protein family HMM TIGR01048; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	Cysteine synthase B; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136.	0.408
SRU_0301	SRU_2363	SRU_0301	SRU_2363	Diaminopimelate decarboxylase; Identified by match to protein family HMM PF00278; match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM PF02784; match to protein family HMM TIGR00657; match to protein family HMM TIGR01048; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	Cys/Met metabolism PLP-dependent enzyme superfamily; Identified by match to protein family HMM PF01053.	0.567
SRU_0301	SRU_2787	SRU_0301	SRU_2787	Diaminopimelate decarboxylase; Identified by match to protein family HMM PF00278; match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM PF02784; match to protein family HMM TIGR00657; match to protein family HMM TIGR01048; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	Cysteine synthase B; Identified by match to protein family HMM PF00291.	0.408
SRU_0301	ThrA	SRU_0301	SRU_0691	Diaminopimelate decarboxylase; Identified by match to protein family HMM PF00278; match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM PF02784; match to protein family HMM TIGR00657; match to protein family HMM TIGR01048; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	Bifunctional aspartokinase/homoserine dehydrogenase I; Identified by match to protein family HMM PF00696; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447; match to protein family HMM TIGR00657.	0.757
SRU_0301	asd	SRU_0301	SRU_1838	Diaminopimelate decarboxylase; Identified by match to protein family HMM PF00278; match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM PF02784; match to protein family HMM TIGR00657; match to protein family HMM TIGR01048; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	Aspartate-semialdehyde dehydrogenase; Identified by match to protein family HMM PF01118; match to protein family HMM PF02774; match to protein family HMM TIGR00978; Belongs to the aspartate-semialdehyde dehydrogenase family.	0.990
SRU_0301	ilvE	SRU_0301	SRU_2317	Diaminopimelate decarboxylase; Identified by match to protein family HMM PF00278; match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM PF02784; match to protein family HMM TIGR00657; match to protein family HMM TIGR01048; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.562
SRU_0301	ldh	SRU_0301	SRU_0681	Diaminopimelate decarboxylase; Identified by match to protein family HMM PF00278; match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM PF02784; match to protein family HMM TIGR00657; match to protein family HMM TIGR01048; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.	0.417
SRU_0301	mdh	SRU_0301	SRU_1571	Diaminopimelate decarboxylase; Identified by match to protein family HMM PF00278; match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM PF02784; match to protein family HMM TIGR00657; match to protein family HMM TIGR01048; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	Malate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.	0.417
SRU_0301	metE	SRU_0301	SRU_1269	Diaminopimelate decarboxylase; Identified by match to protein family HMM PF00278; match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM PF02784; match to protein family HMM TIGR00657; match to protein family HMM TIGR01048; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.	0.457
SRU_0301	metK	SRU_0301	SRU_2755	Diaminopimelate decarboxylase; Identified by match to protein family HMM PF00278; match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM PF02784; match to protein family HMM TIGR00657; match to protein family HMM TIGR01048; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	0.530
SRU_0301	mtnN	SRU_0301	SRU_1556	Diaminopimelate decarboxylase; Identified by match to protein family HMM PF00278; match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM PF02784; match to protein family HMM TIGR00657; match to protein family HMM TIGR01048; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.	0.469
SRU_0301	serC	SRU_0301	SRU_2207	Diaminopimelate decarboxylase; Identified by match to protein family HMM PF00278; match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM PF02784; match to protein family HMM TIGR00657; match to protein family HMM TIGR01048; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.	0.501
SRU_0482	SRU_0301	SRU_0482	SRU_0301	Bifunctional aspartokinase/homoserine dehydrogenase I; Identified by match to protein family HMM PF00742; match to protein family HMM PF03447.	Diaminopimelate decarboxylase; Identified by match to protein family HMM PF00278; match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM PF02784; match to protein family HMM TIGR00657; match to protein family HMM TIGR01048; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.899
SRU_0482	SRU_0922	SRU_0482	SRU_0922	Bifunctional aspartokinase/homoserine dehydrogenase I; Identified by match to protein family HMM PF00742; match to protein family HMM PF03447.	Truncated methionine synthase-like protein; Identified by match to protein family HMM PF01717.	0.851