STRINGSTRING
rpe rpe SRU_0069 SRU_0069 zwf zwf gnd gnd tal tal ppc ppc tkt tkt tal-2 tal-2 SRU_0423 SRU_0423 SRU_0424 SRU_0424 prsA prsA cysD cysD sdhB sdhB sdhA sdhA SRU_0486 SRU_0486 SRU_0487 SRU_0487 citA citA gdhA gdhA rpiA rpiA sucD sucD glyA glyA SRU_0785 SRU_0785 eno eno SRU_0811 SRU_0811 prs prs pfkA pfkA pycA pycA pgl pgl accB accB accC-2 accC-2 pykA pykA sucC sucC ppsA ppsA accD accD gap gap SRU_1210 SRU_1210 gcvP gcvP SRU_1413 SRU_1413 yfcX yfcX fbp fbp SRU_1477 SRU_1477 SRU_1547 SRU_1547 SRU_1550 SRU_1550 mdh mdh lpdA lpdA fumC fumC gcvT gcvT SRU_1677 SRU_1677 acs acs SRU_1701 SRU_1701 SRU_1786 SRU_1786 SRU_1791 SRU_1791 mutA mutA acs-2 acs-2 pckA pckA folD folD fbp-2 fbp-2 acnA acnA tpiA tpiA SRU_1906 SRU_1906 tal-3 tal-3 SRU_1969 SRU_1969 SRU_1970 SRU_1970 pdhA pdhA icd icd SRU_1986 SRU_1986 gcvH gcvH metF metF pfkA-2 pfkA-2 serC serC pccB pccB SRU_2255 SRU_2255 ilvA-2 ilvA-2 accA accA gpmI gpmI pckA-2 pckA-2 SRU_2444 SRU_2444
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rpeRibulose-phosphate 3-epimerase; Identified by match to protein family HMM PF00834; match to protein family HMM TIGR01163; Belongs to the ribulose-phosphate 3-epimerase family. (244 aa)
SRU_0069Putative phosphate acetyltransferase/enoyl-CoA hydratase fusion protein; Identified by match to protein family HMM PF01575. (148 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (504 aa)
gnd6-phosphogluconate dehydrogenase (decarboxylating); Identified by match to protein family HMM PF00393; match to protein family HMM PF03446; match to protein family HMM TIGR00872. (329 aa)
talPutative Transaldolase Phosphoglucose isomerase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the GPI family. (920 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (957 aa)
tktTransketolase; Identified by match to protein family HMM PF00456; match to protein family HMM PF02779; match to protein family HMM PF02780; match to protein family HMM TIGR00232; Belongs to the transketolase family. (676 aa)
tal-2Transaldolase, putative; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (226 aa)
SRU_0423Pyruvate synthase; Identified by match to protein family HMM PF01558; match to protein family HMM PF01855. (632 aa)
SRU_04242-oxoacid:ferredoxin oxidoreductase, beta subunit; Identified by match to protein family HMM PF02775. (454 aa)
prsARibose-phosphate pyrophosphokinase; Identified by match to protein family HMM PF00156; match to protein family HMM TIGR01251. (325 aa)
cysDO-acetylhomoserine sulfhydrylase; Identified by match to protein family HMM PF01053; match to protein family HMM PF01212; match to protein family HMM TIGR01326. (470 aa)
sdhBSuccinate dehydrogenase, iron-sulfur protein; Identified by match to protein family HMM PF00037; match to protein family HMM TIGR00384. (243 aa)
sdhASuccinate dehydrogenase, flavoprotein subunit; Identified by match to protein family HMM PF00890; match to protein family HMM PF01266; match to protein family HMM PF02910; match to protein family HMM PF07992; match to protein family HMM TIGR01812; match to protein family HMM TIGR01816. (611 aa)
SRU_0486Succinate dehydrogenase, membrane subunit, putative. (150 aa)
SRU_0487Putative succinate dehydrogenase membrane subunit; Identified by match to protein family HMM PF01127. (164 aa)
citACitrate synthase; Identified by match to protein family HMM PF00285; match to protein family HMM TIGR01800; Belongs to the citrate synthase family. (451 aa)
gdhAGlutamate dehydrogenase; Identified by similarity to SP:P96110; match to protein family HMM PF00208; match to protein family HMM PF02812; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (434 aa)
rpiARibose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (274 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (288 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (432 aa)
SRU_0785Xylose repressor; Identified by match to protein family HMM PF00480. (327 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa)
SRU_08112-oxo acid dehydrogenases acyltransferase (catalytic domain) protein; Identified by match to protein family HMM PF00198; match to protein family HMM PF00364; match to protein family HMM PF02817. (639 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (320 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (360 aa)
pycAPyruvate carboxylase; Identified by match to protein family HMM PF00364. (186 aa)
pgl6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (276 aa)
accBacetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (209 aa)
accC-2acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (491 aa)
pykAPyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. (476 aa)
sucCsuccinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (392 aa)
ppsAPhosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (824 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (282 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase, type I; Identified by match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
SRU_12103-hydroxyacyl-CoA dehydrogenase, C-terminal domain family; Identified by match to protein family HMM PF00378; match to protein family HMM PF00725; match to protein family HMM PF02737. (802 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (980 aa)
SRU_14133-hydroxybutyryl-CoA dehydrogenase; Identified by match to protein family HMM PF00725; match to protein family HMM PF02737. (284 aa)
yfcXFatty oxidation complex, alpha subunit; Identified by match to protein family HMM PF00378; match to protein family HMM PF00725; match to protein family HMM PF02737; Belongs to the enoyl-CoA hydratase/isomerase family. (719 aa)
fbpFructose-1,6-bisphosphatase; Identified by match to protein family HMM PF00316. (356 aa)
SRU_1477Aconitate hydratase, putative; Identified by match to protein family HMM PF00330; match to protein family HMM PF00694; match to protein family HMM TIGR01342. (658 aa)
SRU_1547acetyl-CoA acetyltransferase; Identified by match to protein family HMM PF00108; match to protein family HMM PF02803; match to protein family HMM TIGR01930; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
SRU_1550Hydroxypyruvate reductase; Identified by match to protein family HMM PF05161. (472 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (314 aa)
lpdADihydrolipoamide dehydrogenase; Identified by match to protein family HMM PF00070; match to protein family HMM PF02852; match to protein family HMM PF07992; match to protein family HMM TIGR01350. (489 aa)
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (601 aa)
gcvTGlycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (374 aa)
SRU_1677Putative (NAD+) isocitrate dehydrogenase ^; Identified by match to protein family HMM PF00180. (340 aa)
acsacetyl-CoA synthase; Identified by match to protein family HMM PF00501. (663 aa)
SRU_1701Acyl-coenzyme A oxidase I, putative; Identified by match to protein family HMM PF00441; match to protein family HMM PF01756; match to protein family HMM PF02770. (786 aa)
SRU_1786NAD-dependent malic enzyme; Identified by match to protein family HMM PF00390; match to protein family HMM PF01842; match to protein family HMM PF03949. (493 aa)
SRU_1791Methylmalonyl-CoA mutase superfamily; Identified by match to protein family HMM PF01642. (648 aa)
mutAmethylmalonyl-CoA mutase, beta subunit; Identified by match to protein family HMM PF01642; match to protein family HMM PF02310; match to protein family HMM TIGR00640; match to protein family HMM TIGR00641. (717 aa)
acs-2acetyl-CoA synthetase; Identified by match to protein family HMM PF00501. (624 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (535 aa)
folDFolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (297 aa)
fbp-2Fructose-1,6-bisphosphatase; Identified by match to protein family HMM PF00316. (396 aa)
acnAAconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (910 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (260 aa)
SRU_1906Deoxyribose-phosphate aldolase family; Identified by match to protein family HMM PF01791. (437 aa)
tal-3Transaldolase, putative; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (224 aa)
SRU_1969Dihydrolipoyllysine-residue acetyltransferase component of pyruvatedehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (465 aa)
SRU_1970Pyruvate dehydrogenase E1 component, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (327 aa)
pdhAPyruvate dehydrogenase E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (470 aa)
icdIsocitrate dehydrogenase, NADP-dependent; Identified by match to protein family HMM PF00180; match to protein family HMM TIGR00183. (411 aa)
SRU_1986Metalloenzyme superfamily protein; Identified by match to protein family HMM PF01676. (307 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (124 aa)
metF5,10-methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; match to protein family HMM TIGR00676; Belongs to the methylenetetrahydrofolate reductase family. (319 aa)
pfkA-2Phosphofructokinase subfamily; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (379 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (369 aa)
pccBPutative propionyl-CoA carboxylase beta chain protein; Identified by match to protein family HMM PF01039. (561 aa)
SRU_2255Glutamate dehydrogenase, short peptide; Identified by match to protein family HMM PF00208; match to protein family HMM PF02812; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (553 aa)
ilvA-2Threonine dehydratase; Identified by match to protein family HMM PF00291; match to protein family HMM PF01842; match to protein family HMM TIGR01127. (470 aa)
accAacetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (335 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (523 aa)
pckA-2Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (530 aa)
SRU_2444FAD binding domain protein; Identified by match to protein family HMM PF00890; match to protein family HMM PF01266; match to protein family HMM PF02910; match to protein family HMM PF07992. (581 aa)
Your Current Organism:
Salinibacter ruber
NCBI taxonomy Id: 309807
Other names: S. ruber DSM 13855, Salinibacter ruber DSM 13855, Salinibacter ruber str. DSM 13855, Salinibacter ruber strain DSM 13855
Server load: low (16%) [HD]