(13 nodes) IL-6-type cytokine receptor ligand interactions, and T-helper 17 cell differentiation network (Takifugu rubripes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101067982	Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (483 aa)
	il6r	Fibronectin type-III domain-containing protein. (539 aa)
	il-6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (227 aa)
	il6st	Uncharacterized protein. (862 aa)
	LOC101078464	IL-6 subfamily cytokine M17. (235 aa)
	LOC101063859	Epstein-Barr virus induced 3. (252 aa)
	LOC101061818	LIF receptor subunit alpha a. (974 aa)
	ENSTRUP00000051078	Uncharacterized protein. (572 aa)
	Cntfr	Uncharacterized protein. (292 aa)
	clcf1	Cardiotrophin-like cytokine factor 1. (488 aa)
	il-11a	Interleukin 11a. (201 aa)
	ENSTRUP00000084423	Uncharacterized protein LOC105419816. (418 aa)
	LOC115250187	Ciliary neurotrophic factor receptor subunit alpha-like. (457 aa)

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cntfr	ENSTRUP00000051078	ENSTRUP00000054797	ENSTRUP00000051078	Uncharacterized protein.	Uncharacterized protein.	0.685
Cntfr	LOC101061818	ENSTRUP00000054797	ENSTRUP00000042823	Uncharacterized protein.	LIF receptor subunit alpha a.	0.902
Cntfr	LOC101078464	ENSTRUP00000054797	ENSTRUP00000031435	Uncharacterized protein.	IL-6 subfamily cytokine M17.	0.607
Cntfr	clcf1	ENSTRUP00000054797	ENSTRUP00000058873	Uncharacterized protein.	Cardiotrophin-like cytokine factor 1.	0.924
Cntfr	il-11a	ENSTRUP00000054797	ENSTRUP00000070272	Uncharacterized protein.	Interleukin 11a.	0.582
Cntfr	il6st	ENSTRUP00000054797	ENSTRUP00000030055	Uncharacterized protein.	Uncharacterized protein.	0.934
ENSTRUP00000051078	Cntfr	ENSTRUP00000051078	ENSTRUP00000054797	Uncharacterized protein.	Uncharacterized protein.	0.685
ENSTRUP00000051078	LOC101063859	ENSTRUP00000051078	ENSTRUP00000040244	Uncharacterized protein.	Epstein-Barr virus induced 3.	0.685
ENSTRUP00000051078	LOC115250187	ENSTRUP00000051078	ENSTRUP00000085631	Uncharacterized protein.	Ciliary neurotrophic factor receptor subunit alpha-like.	0.685
ENSTRUP00000051078	il-11a	ENSTRUP00000051078	ENSTRUP00000070272	Uncharacterized protein.	Interleukin 11a.	0.623
ENSTRUP00000051078	il6r	ENSTRUP00000051078	ENSTRUP00000007361	Uncharacterized protein.	Fibronectin type-III domain-containing protein.	0.691
ENSTRUP00000084423	LOC101063859	ENSTRUP00000084423	ENSTRUP00000040244	Uncharacterized protein LOC105419816.	Epstein-Barr virus induced 3.	0.569
ENSTRUP00000084423	LOC115250187	ENSTRUP00000084423	ENSTRUP00000085631	Uncharacterized protein LOC105419816.	Ciliary neurotrophic factor receptor subunit alpha-like.	0.424
ENSTRUP00000084423	il6r	ENSTRUP00000084423	ENSTRUP00000007361	Uncharacterized protein LOC105419816.	Fibronectin type-III domain-containing protein.	0.445
LOC101061818	Cntfr	ENSTRUP00000042823	ENSTRUP00000054797	LIF receptor subunit alpha a.	Uncharacterized protein.	0.902
LOC101061818	LOC115250187	ENSTRUP00000042823	ENSTRUP00000085631	LIF receptor subunit alpha a.	Ciliary neurotrophic factor receptor subunit alpha-like.	0.401
LOC101061818	clcf1	ENSTRUP00000042823	ENSTRUP00000058873	LIF receptor subunit alpha a.	Cardiotrophin-like cytokine factor 1.	0.929
LOC101061818	il-11a	ENSTRUP00000042823	ENSTRUP00000070272	LIF receptor subunit alpha a.	Interleukin 11a.	0.652
LOC101061818	il6r	ENSTRUP00000042823	ENSTRUP00000007361	LIF receptor subunit alpha a.	Fibronectin type-III domain-containing protein.	0.627
LOC101061818	il6st	ENSTRUP00000042823	ENSTRUP00000030055	LIF receptor subunit alpha a.	Uncharacterized protein.	0.903