(113 nodes) Trypsin-like serine protease, and Coagulation network (Takifugu rubripes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105418898	Peptidase S1 domain-containing protein. (242 aa)
	LOC101074340	Zmp:0000001114. (839 aa)
	LOC101076928	Zgc:163079; Belongs to the peptidase S1 family. (303 aa)
	ENSTRUP00000001552	Granzyme K-like isoform X1. (110 aa)
	GRB14	Growth factor receptor bound protein 14. (528 aa)
	H2RR26_TAKRU	Peptidase S1 domain-containing protein. (288 aa)
	LOC101065030	Uncharacterized protein. (363 aa)
	APOH	Uncharacterized protein. (350 aa)
	LOC101064607	Uncharacterized protein; Belongs to the peptidase S1 family. (442 aa)
	LOC101074356	Zgc:112160; Belongs to the peptidase S1 family. (264 aa)
	fgb	Fibrinogen beta chain. (491 aa)
	TMPRSS2	Transmembrane serine protease 2; Belongs to the peptidase S1 family. (400 aa)
	LOC101074582	Zgc:136461; Belongs to the peptidase S1 family. (263 aa)
	serpinf2	SERPIN domain-containing protein; Belongs to the serpin family. (434 aa)
	LOC101077681	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (264 aa)
	LOC445941	Coagulation factor VII, like. (498 aa)
	LOC446072	Coagulation factor VII. (441 aa)
	LOC101073645	Serine peptidase inhibitor, Kunitz type 1 b. (502 aa)
	f10	Uncharacterized protein. (489 aa)
	LOC101072918	Uncharacterized protein; Belongs to the peptidase S1 family. (665 aa)
	f2r	Coagulation factor II (thrombin) receptor; Belongs to the G-protein coupled receptor 1 family. (413 aa)
	LOC101066245	Uncharacterized protein. (552 aa)
	f2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (648 aa)
	serpina10	Si:ch1073-416d2.3; Belongs to the serpin family. (404 aa)
	fgg	Fibrinogen gamma chain. (446 aa)
	H2SV07_TAKRU	Coagulation factor II (thrombin) receptor-like 2. (357 aa)
	LOC101078065	Tissue factor pathway inhibitor. (280 aa)
	f9	Uncharacterized protein. (552 aa)
	LOC101064442	Zmp:0000001088; Belongs to the peptidase S1 family. (279 aa)
	LOC101061223	Uncharacterized protein. (282 aa)
	LOC101064664	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (240 aa)
	plg	Uncharacterized protein; Belongs to the peptidase S1 family. (759 aa)
	LOC101078898	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (322 aa)
	Ambp	Uncharacterized protein. (355 aa)
	H2TJR6_TAKRU	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (262 aa)
	hgfac	HGF activator. (605 aa)
	ENSTRUP00000026373	annotation not available (142 aa)
	LOC101079350	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (480 aa)
	serpinc1	Serpin peptidase inhibitor, clade C (antithrombin), member 1; Belongs to the serpin family. (450 aa)
	st14	Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. (847 aa)
	serpine2	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Belongs to the serpin family. (397 aa)
	erap2	Aminopeptidase. (935 aa)
	LOC101064399	GLOBIN domain-containing protein; Belongs to the globin family. (146 aa)
	LOC101064621	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (290 aa)
	tmprss9	Transmembrane serine protease 9; Belongs to the peptidase S1 family. (306 aa)
	serpind1	Serpin peptidase inhibitor, clade D (heparin cofactor), member 1; Belongs to the serpin family. (502 aa)
	spint1	Serine peptidase inhibitor, Kunitz type 1 a. (542 aa)
	LOC101067258	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (243 aa)
	LOC101071730	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (245 aa)
	f8	Uncharacterized protein; Belongs to the multicopper oxidase family. (1638 aa)
	LOC101072621	Uncharacterized protein. (191 aa)
	tfpi2	Tissue factor pathway inhibitor 2. (226 aa)
	LOC101066031	Protein Z, vitamin K-dependent plasma glycoprotein a; Belongs to the peptidase S1 family. (419 aa)
	LOC101064923	Microseminoprotein, beta-like. (314 aa)
	LOC101069212	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (315 aa)
	LOC101065526	Carboxypeptidase B1 (tissue). (416 aa)
	Prtn3	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (250 aa)
	ENSTRUP00000046879	Serine protease 48-like. (124 aa)
	LOC105417576	Peptidase S1 domain-containing protein. (322 aa)
	LOC101078077	Coagulation factor II (thrombin) receptor-like 1, tandem duplicate 1. (385 aa)
	LOC115246798	Elastase-1-like isoform X1. (272 aa)
	LOC101071041	Serine protease 1; Belongs to the peptidase S1 family. (365 aa)
	ctrl	Zgc:171592; Belongs to the peptidase S1 family. (263 aa)
	ENSTRUP00000048874	Granzyme A-like. (90 aa)
	LOC101065337	Peptidase S1 domain-containing protein. (271 aa)
	ENSTRUP00000050343	Uncharacterized protein. (129 aa)
	LOC101073626	Kazal-like domain-containing protein. (79 aa)
	LOC101064674	Parvalbumin 9; Belongs to the parvalbumin family. (122 aa)
	LOC101073906	Transmembrane serine protease 13b; Belongs to the peptidase S1 family. (496 aa)
	f9-2	Coagulation factor IXa. (510 aa)
	ENSTRUP00000054732	BPTI/Kunitz inhibitor domain-containing protein. (95 aa)
	LOC105416693	Serine protease 1; Belongs to the peptidase S1 family. (246 aa)
	LOC101064847	Coagulation factor II (thrombin) receptor-like 1, tandem duplicate 2. (424 aa)
	LOC445940	Coagulation factor VIIi. (442 aa)
	tmprss5	Transmembrane serine protease 5; Belongs to the peptidase S1 family. (477 aa)
	ENSTRUP00000057628	annotation not available (143 aa)
	LOC101070721	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (251 aa)
	LOC101066992	Serine protease 59, tandem duplicate 1; Belongs to the peptidase S1 family. (251 aa)
	H2SRM3_TAKRU	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (291 aa)
	f3	Coagulation factor IIIa. (298 aa)
	LOC101078862	Hepatocyte growth factor a; Belongs to the peptidase S1 family. Plasminogen subfamily. (717 aa)
	LOC101074247	Uncharacterized protein. (852 aa)
	LOC105419222	Uncharacterized protein. (1287 aa)
	LOC101075775	Peptidase S1 domain-containing protein. (311 aa)
	ENSTRUP00000067126	annotation not available (355 aa)
	LOC101063812	Vitronectin b. (468 aa)
	LOC105417669	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (248 aa)
	H2S1K7_TAKRU	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (304 aa)
	plat	Plasminogen activator, tissue. (711 aa)
	LOC101066693	Hemoglobin beta embryonic-2; Belongs to the globin family. (147 aa)
	LOC101071304	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (270 aa)
	ENSTRUP00000069922	annotation not available (82 aa)
	ENSTRUP00000072129	annotation not available (694 aa)
	H2SH89_TAKRU	Peptidase S1 domain-containing protein. (644 aa)
	LOC101068458	Plasminogen activator, urokinase a; Belongs to the peptidase S1 family. (411 aa)
	LOC101073986	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (722 aa)
	LOC101076681	Alpha-2-HS-glycoprotein 2. (353 aa)
	ENSTRUP00000075880	Granzyme A. (180 aa)
	F2RL2	Coagulation factor II thrombin receptor like 2. (376 aa)
	ENSTRUP00000077667	annotation not available (97 aa)
	serpine1	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (419 aa)
	LOC101070853	Uncharacterized protein. (2227 aa)
	ENSTRUP00000078721	annotation not available (624 aa)
	ENSTRUP00000078747	Coagulation factor III (tissue factor). (259 aa)
	HBA4	Hemoglobin alpha 4 subunit; Belongs to the globin family. (192 aa)
	ENSTRUP00000079975	annotation not available (206 aa)
	LOC105417895	Uncharacterized protein. (452 aa)
	proc	Protein C (inactivator of coagulation factors Va and VIIIa), a. (439 aa)
	LOC101077973	Elastase 3 like; Belongs to the peptidase S1 family. (291 aa)
	ENSTRUP00000083312	annotation not available (267 aa)
	ENSTRUP00000085811	Serine protease 33-like. (356 aa)
	ENSTRUP00000087704	annotation not available (257 aa)
	HBA3	Hemoglobin, alpha embryonic 5; Belongs to the globin family. (135 aa)

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOH	Ambp	ENSTRUP00000003101	ENSTRUP00000023858	Uncharacterized protein.	Uncharacterized protein.	0.650
APOH	ENSTRUP00000077667	ENSTRUP00000003101	ENSTRUP00000077667	Uncharacterized protein.	annotation not available	0.472
APOH	ENSTRUP00000087704	ENSTRUP00000003101	ENSTRUP00000087704	Uncharacterized protein.	annotation not available	0.650
APOH	LOC101064923	ENSTRUP00000003101	ENSTRUP00000044221	Uncharacterized protein.	Microseminoprotein, beta-like.	0.521
APOH	LOC101076681	ENSTRUP00000003101	ENSTRUP00000075197	Uncharacterized protein.	Alpha-2-HS-glycoprotein 2.	0.712
APOH	LOC105417895	ENSTRUP00000003101	ENSTRUP00000080271	Uncharacterized protein.	Uncharacterized protein.	0.712
APOH	f2	ENSTRUP00000003101	ENSTRUP00000014352	Uncharacterized protein.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.823
APOH	fgb	ENSTRUP00000003101	ENSTRUP00000006154	Uncharacterized protein.	Fibrinogen beta chain.	0.558
APOH	fgg	ENSTRUP00000003101	ENSTRUP00000014823	Uncharacterized protein.	Fibrinogen gamma chain.	0.741
APOH	plg	ENSTRUP00000003101	ENSTRUP00000021511	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase S1 family.	0.744
APOH	proc	ENSTRUP00000003101	ENSTRUP00000081036	Uncharacterized protein.	Protein C (inactivator of coagulation factors Va and VIIIa), a.	0.472
APOH	serpinc1	ENSTRUP00000003101	ENSTRUP00000026676	Uncharacterized protein.	Serpin peptidase inhibitor, clade C (antithrombin), member 1; Belongs to the serpin family.	0.771
APOH	serpind1	ENSTRUP00000003101	ENSTRUP00000033122	Uncharacterized protein.	Serpin peptidase inhibitor, clade D (heparin cofactor), member 1; Belongs to the serpin family.	0.532
APOH	serpinf2	ENSTRUP00000003101	ENSTRUP00000007599	Uncharacterized protein.	SERPIN domain-containing protein; Belongs to the serpin family.	0.507
Ambp	APOH	ENSTRUP00000023858	ENSTRUP00000003101	Uncharacterized protein.	Uncharacterized protein.	0.650
Ambp	ENSTRUP00000077667	ENSTRUP00000023858	ENSTRUP00000077667	Uncharacterized protein.	annotation not available	0.480
Ambp	LOC101064442	ENSTRUP00000023858	ENSTRUP00000018111	Uncharacterized protein.	Zmp:0000001088; Belongs to the peptidase S1 family.	0.567
Ambp	LOC101064923	ENSTRUP00000023858	ENSTRUP00000044221	Uncharacterized protein.	Microseminoprotein, beta-like.	0.627
Ambp	LOC101065030	ENSTRUP00000023858	ENSTRUP00000003099	Uncharacterized protein.	Uncharacterized protein.	0.650
Ambp	LOC101066992	ENSTRUP00000023858	ENSTRUP00000062791	Uncharacterized protein.	Serine protease 59, tandem duplicate 1; Belongs to the peptidase S1 family.	0.567