(62 nodes) Protease binding network (Takifugu rubripes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	timp2	Tissue inhibitor of metalloproteinase 2a. (220 aa)
	LOC115251968	Selenoprotein S-like. (154 aa)
	polg	Polymerase (DNA directed), gamma. (1197 aa)
	H2RLI5_TAKRU	Uncharacterized protein. (185 aa)
	LOC100049642	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (434 aa)
	serpinf2	SERPIN domain-containing protein; Belongs to the serpin family. (434 aa)
	LOC101075979	PDZ domain containing 3b. (527 aa)
	H2SAI0_TAKRU	Receptor-interacting serine-threonine kinase 2. (554 aa)
	rnf139	Ring finger protein 139. (702 aa)
	LOC105416219	MALT paracaspase 3. (589 aa)
	twnk	Twinkle mtDNA helicase. (715 aa)
	LOC100049643	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (483 aa)
	ADRM1	Adhesion regulating molecule 1. (437 aa)
	brca2	BRCA2 DNA repair associated. (2718 aa)
	yipf5	Protein YIPF. (257 aa)
	fbxo45	F-box protein 45. (289 aa)
	LOC101061223	Uncharacterized protein. (282 aa)
	cltc	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1678 aa)
	pink1	PTEN induced kinase 1. (568 aa)
	LOC101075280	E3 ubiquitin-protein ligase MARCH6-like. (911 aa)
	amfr	Autocrine motility factor receptor b. (645 aa)
	LOC101068194	SERPIN domain-containing protein; Belongs to the serpin family. (476 aa)
	Casp8ap2	Uncharacterized protein. (1685 aa)
	LOC115251215	Serine/threonine-protein kinase RIO3-like. (509 aa)
	LOC101078281	Serine/threonine-protein kinase RIO3; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (514 aa)
	LOC101073992	Uncharacterized protein. (456 aa)
	ENSTRUP00000078747	Coagulation factor III (tissue factor). (259 aa)
	serpine1	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (419 aa)
	malt1	MALT paracaspase 1. (836 aa)
	ENSTRUP00000077339	Selenoprotein S. (214 aa)
	LOC101069090	MALT paracaspase 2. (816 aa)
	flot1	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (464 aa)
	ENSTRUP00000073805	Na(+)/H(+) exchange regulatory cofactor NHE-RF3-like isoform X1. (179 aa)
	selenos	Selenoprotein S. (174 aa)
	LOC101061998	Fibronectin 1a. (2503 aa)
	LOC101071667	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1677 aa)
	psap	Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (586 aa)
	f3	Coagulation factor IIIa. (298 aa)
	prkn	Ubiquitin-like domain-containing protein. (532 aa)
	LOC101067067	DED domain-containing protein. (196 aa)
	FLOT1	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (441 aa)
	LOC101077362	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1662 aa)
	ENSTRUP00000059060	Integrin alpha-3-like isoform X1. (676 aa)
	ENSTRUP00000057743	Uncharacterized protein. (169 aa)
	ENSTRUP00000056963	annotation not available (197 aa)
	ENSTRUP00000054856	CASP2 and RIPK1 domain containing adaptor with death domain. (114 aa)
	timp3	NTR domain-containing protein. (214 aa)
	LOC101075023	BCL2 like 10. (194 aa)
	LOC105418031	Surfactant protein Bb. (353 aa)
	reep1	Receptor accessory protein 1. (203 aa)
	tnfaip3	Tumor necrosis factor, alpha-induced protein 3. (823 aa)
	timp4	TIMP metallopeptidase inhibitor 4, tandem duplicate 2. (224 aa)
	LOC101064312	Uncharacterized protein. (459 aa)
	nfrkb	Nuclear factor related to kappaB binding protein. (1287 aa)
	itga3	Integrin, alpha 3b; Belongs to the integrin alpha chain family. (1065 aa)
	trip4	Thyroid hormone receptor interactor 4. (622 aa)
	BFAR	Bifunctional apoptosis regulator. (450 aa)
	BDKRB2	Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (345 aa)
	cflar	Uncharacterized protein; Belongs to the peptidase C14A family. (470 aa)
	timp-2b	NTR domain-containing protein. (219 aa)
	serpinc1	Serpin peptidase inhibitor, clade C (antithrombin), member 1; Belongs to the serpin family. (450 aa)
	marchf6	Membrane-associated ring finger (C3HC4) 6. (915 aa)

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRM1	prkn	ENSTRUP00000014793	ENSTRUP00000062233	Adhesion regulating molecule 1.	Ubiquitin-like domain-containing protein.	0.693
BFAR	ENSTRUP00000054856	ENSTRUP00000040054	ENSTRUP00000054856	Bifunctional apoptosis regulator.	CASP2 and RIPK1 domain containing adaptor with death domain.	0.499
ENSTRUP00000054856	BFAR	ENSTRUP00000054856	ENSTRUP00000040054	CASP2 and RIPK1 domain containing adaptor with death domain.	Bifunctional apoptosis regulator.	0.499
ENSTRUP00000054856	ENSTRUP00000056963	ENSTRUP00000054856	ENSTRUP00000056963	CASP2 and RIPK1 domain containing adaptor with death domain.	annotation not available	0.527
ENSTRUP00000054856	LOC101067067	ENSTRUP00000054856	ENSTRUP00000061734	CASP2 and RIPK1 domain containing adaptor with death domain.	DED domain-containing protein.	0.527
ENSTRUP00000054856	cflar	ENSTRUP00000054856	ENSTRUP00000032170	CASP2 and RIPK1 domain containing adaptor with death domain.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.407
ENSTRUP00000056963	ENSTRUP00000054856	ENSTRUP00000056963	ENSTRUP00000054856	annotation not available	CASP2 and RIPK1 domain containing adaptor with death domain.	0.527
ENSTRUP00000056963	H2SAI0_TAKRU	ENSTRUP00000056963	ENSTRUP00000009406	annotation not available	Receptor-interacting serine-threonine kinase 2.	0.641
ENSTRUP00000056963	LOC101073992	ENSTRUP00000056963	ENSTRUP00000078844	annotation not available	Uncharacterized protein.	0.600
ENSTRUP00000056963	cflar	ENSTRUP00000056963	ENSTRUP00000032170	annotation not available	Uncharacterized protein; Belongs to the peptidase C14A family.	0.870
ENSTRUP00000056963	prkn	ENSTRUP00000056963	ENSTRUP00000062233	annotation not available	Ubiquitin-like domain-containing protein.	0.455
ENSTRUP00000056963	tnfaip3	ENSTRUP00000056963	ENSTRUP00000048051	annotation not available	Tumor necrosis factor, alpha-induced protein 3.	0.613
ENSTRUP00000057743	ENSTRUP00000059060	ENSTRUP00000057743	ENSTRUP00000059060	Uncharacterized protein.	Integrin alpha-3-like isoform X1.	0.412
ENSTRUP00000057743	H2RLI5_TAKRU	ENSTRUP00000057743	ENSTRUP00000000998	Uncharacterized protein.	Uncharacterized protein.	0.687
ENSTRUP00000059060	ENSTRUP00000057743	ENSTRUP00000059060	ENSTRUP00000057743	Integrin alpha-3-like isoform X1.	Uncharacterized protein.	0.412
ENSTRUP00000059060	H2RLI5_TAKRU	ENSTRUP00000059060	ENSTRUP00000000998	Integrin alpha-3-like isoform X1.	Uncharacterized protein.	0.911
ENSTRUP00000059060	LOC101061998	ENSTRUP00000059060	ENSTRUP00000068642	Integrin alpha-3-like isoform X1.	Fibronectin 1a.	0.916
ENSTRUP00000059060	itga3	ENSTRUP00000059060	ENSTRUP00000042215	Integrin alpha-3-like isoform X1.	Integrin, alpha 3b; Belongs to the integrin alpha chain family.	0.901
ENSTRUP00000078747	serpinc1	ENSTRUP00000078747	ENSTRUP00000026676	Coagulation factor III (tissue factor).	Serpin peptidase inhibitor, clade C (antithrombin), member 1; Belongs to the serpin family.	0.403
ENSTRUP00000078747	serpine1	ENSTRUP00000078747	ENSTRUP00000077919	Coagulation factor III (tissue factor).	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family.	0.401