(114 nodes) Ubiquitin-like protein peptidase activity network (Takifugu rubripes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	usp25	Ubiquitin specific peptidase 25; Belongs to the peptidase C19 family. (1019 aa)
	ENSTRUP00000000520	Ubiquitin carboxyl-terminal hydrolase CYLD-like. (668 aa)
	usp45	Ubiquitinyl hydrolase 1. (799 aa)
	LOC101077697	Zinc finger, RAN-binding domain containing 1b. (755 aa)
	mpnd	MPN domain containing. (454 aa)
	LOC101068606	SUMO specific peptidase 3b. (555 aa)
	josd2	Josephin domain containing 2. (184 aa)
	ufsp1	UFM1-specific peptidase 1 (non-functional). (241 aa)
	brcc3	BRCA1/BRCA2-containing complex, subunit 3. (260 aa)
	VCPIP1	Deubiquitinating protein VCIP135. (1112 aa)
	vcpip1	Valosin containing protein (p97)/p47 complex interacting protein 1. (1114 aa)
	usp19	Ubiquitin specific peptidase 19. (1497 aa)
	usp12	Ubiquitin specific peptidase 12a; Belongs to the peptidase C19 family. (372 aa)
	usp37	Ubiquitin carboxyl-terminal hydrolase. (714 aa)
	usp4	Ubiquitin carboxyl-terminal hydrolase. (1001 aa)
	LOC101073729	Ataxin 3. (223 aa)
	zup1	Zinc finger containing ubiquitin peptidase 1. (579 aa)
	otud3	OTU deubiquitinase 3. (354 aa)
	eif3h	Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (341 aa)
	LOC101077845	Ubiquitin specific peptidase 43b; Belongs to the peptidase C19 family. (1184 aa)
	usp49	Ubiquitin carboxyl-terminal hydrolase. (670 aa)
	senp5	ULP_PROTEASE domain-containing protein. (246 aa)
	ZRANB1	Zinc finger RANBP2-type containing 1. (718 aa)
	zc3h12a	Si:dkey-206d17.12. (176 aa)
	uchl3	Ubiquitin carboxyl-terminal hydrolase. (232 aa)
	LOC101076023	DUF862 domain-containing protein. (195 aa)
	LOC101071687	USP domain-containing protein; Belongs to the peptidase C19 family. (336 aa)
	usp36	Ubiquitin specific peptidase 36; Belongs to the peptidase C19 family. (1120 aa)
	usp39	Ubiquitin specific peptidase 39. (500 aa)
	yod1	YOD1 deubiquitinase. (306 aa)
	otub1	Ubiquitin thioesterase. (269 aa)
	LOC101078481	Ubiquitin specific peptidase 2b; Belongs to the peptidase C19 family. (395 aa)
	usp28	Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family. (1411 aa)
	usp3	Ubiquitin carboxyl-terminal hydrolase. (612 aa)
	usp43	Ubiquitin specific peptidase 43a; Belongs to the peptidase C19 family. (1221 aa)
	otud7b	OTU deubiquitinase 7B. (926 aa)
	bap1	Ubiquitin carboxyl-terminal hydrolase. (746 aa)
	usp38	Ubiquitin specific peptidase 38; Belongs to the peptidase C19 family. (1026 aa)
	usp30	Ubiquitin carboxyl-terminal hydrolase. (494 aa)
	usp40	Ubiquitin specific peptidase 40; Belongs to the peptidase C19 family. (1282 aa)
	usp16	Ubiquitin carboxyl-terminal hydrolase 16; Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. (823 aa)
	stambp	STAM binding protein b. (428 aa)
	SENP6	Uncharacterized protein. (1065 aa)
	uchl1	Ubiquitin carboxyl-terminal hydrolase. (220 aa)
	cep112	Centrosomal protein 112. (941 aa)
	USP24	Ubiquitin specific peptidase 24. (2615 aa)
	mysm1	Histone H2A deubiquitinase MYSM1. (872 aa)
	senp8	SUMO peptidase family member, NEDD8 specific. (221 aa)
	USP50	Ubiquitin carboxyl-terminal hydrolase. (306 aa)
	usp8	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1086 aa)
	josd1	Josephin domain containing 1. (260 aa)
	psmd14	Proteasome 26S subunit, non-ATPase 14. (332 aa)
	LOC101071937	Ubiquitin carboxyl-terminal hydrolase. (506 aa)
	H2V599_TAKRU	USP domain-containing protein. (811 aa)
	usp13	Ubiquitinyl hydrolase 1. (877 aa)
	ENSTRUP00000045353	Si:dkey-30h22.11. (528 aa)
	mindy2	MINDY lysine 48 deubiquitinase 2. (649 aa)
	otud1	OTU deubiquitinase 1. (427 aa)
	otud6b	OTU domain-containing protein. (292 aa)
	usp20	Ubiquitin carboxyl-terminal hydrolase. (937 aa)
	usp1	Ubiquitin carboxyl-terminal hydrolase. (806 aa)
	tnfaip3	Tumor necrosis factor, alpha-induced protein 3. (823 aa)
	usp11	Ubiquitin specific peptidase 11; Belongs to the peptidase C19 family. (993 aa)
	ENSTRUP00000050485	annotation not available (447 aa)
	LOC105416888	Proline-rich transmembrane protein 4. (898 aa)
	prrt4	Si:dkey-31f5.11. (1050 aa)
	ENSTRUP00000052200	DUF4485 domain-containing protein. (273 aa)
	LOC105416856	USP domain-containing protein; Belongs to the peptidase C19 family. (646 aa)
	otud5	OTU deubiquitinase 5a. (556 aa)
	LOC101078865	Cylindromatosis (turban tumor syndrome), b. (689 aa)
	cops4	COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis). (415 aa)
	LOC101074923	Ubiquitin carboxyl-terminal hydrolase. (523 aa)
	usp14	Ubiquitin carboxyl-terminal hydrolase. (489 aa)
	uchl5	Ubiquitin carboxyl-terminal hydrolase. (334 aa)
	psmd7	Proteasome 26S subunit, non-ATPase 7. (329 aa)
	usp44	Ubiquitin carboxyl-terminal hydrolase. (738 aa)
	LOC101076868	Ubiquitin specific peptidase 21; Belongs to the peptidase C19 family. (417 aa)
	mindy1	MINDY lysine 48 deubiquitinase 1. (554 aa)
	LOC101067757	Ubiquitin specific peptidase 9; Belongs to the peptidase C19 family. (2602 aa)
	LOC101079643	ULP_PROTEASE domain-containing protein. (346 aa)
	USP53	Ubiquitin specific peptidase 53. (1014 aa)
	ENSTRUP00000056491	annotation not available (975 aa)
	LOC101068223	Cytochrome c oxidase assembly factor COX20. (118 aa)
	usp42	Ubiquitin specific peptidase 42; Belongs to the peptidase C19 family. (1010 aa)
	usp48	Ubiquitin specific peptidase 48; Belongs to the peptidase C19 family. (1044 aa)
	otub2	OTU deubiquitinase, ubiquitin aldehyde binding 2. (226 aa)
	ENSTRUP00000061026	STAM binding protein-like 1. (418 aa)
	LOC101065898	OTU deubiquitinase with linear linkage specificity. (695 aa)
	COPS6	COP9 signalosome subunit 6. (330 aa)
	usp10	Ubiquitin carboxyl-terminal hydrolase. (880 aa)
	usp32	Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family. (1600 aa)
	USP34	Uncharacterized protein. (3639 aa)
	usp47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1387 aa)
	LOC101066848	ULP_PROTEASE domain-containing protein. (863 aa)
	LOC101065457	Ubiquitin specific peptidase 53b. (1036 aa)
	LOC101071205	Ubiquitin specific peptidase 12b; Belongs to the peptidase C19 family. (388 aa)
	arfgef1-2	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited). (346 aa)
	LOC101066916	Cylindromatosis (turban tumor syndrome), like. (690 aa)
	usp7	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1137 aa)
	ENSTRUP00000073129	annotation not available (969 aa)
	desi2	Desumoylating isopeptidase 2. (217 aa)
	LOC105417823	Proline-rich transmembrane protein 3-like. (606 aa)
	usp33	Ubiquitin carboxyl-terminal hydrolase. (910 aa)
	desi1	Desumoylating isopeptidase 1a. (168 aa)
	usp5	Ubiquitin carboxyl-terminal hydrolase. (859 aa)
	mindy3	MINDY lysine 48 deubiquitinase 3. (461 aa)
	LOC101062480	Ubiquitin carboxyl-terminal hydrolase 2-like isoform X1. (396 aa)
	LOC101067616	OTU deubiquitinase 7A. (955 aa)
	cyld	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family. (980 aa)
	usp46	Ubiquitin specific peptidase 46; Belongs to the peptidase C19 family. (403 aa)
	EIF3F	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (351 aa)
	senp7	ULP_PROTEASE domain-containing protein. (820 aa)
	ENSTRUP00000087971	LOW QUALITY PROTEIN: SUMO-specific isopeptidase USPL1. (711 aa)
	LOC115251519	USP domain-containing protein. (311 aa)

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COPS6	EIF3F	ENSTRUP00000065015	ENSTRUP00000084787	COP9 signalosome subunit 6.	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.543
COPS6	arfgef1-2	ENSTRUP00000065015	ENSTRUP00000070411	COP9 signalosome subunit 6.	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited).	0.998
COPS6	bap1	ENSTRUP00000065015	ENSTRUP00000035472	COP9 signalosome subunit 6.	Ubiquitin carboxyl-terminal hydrolase.	0.646
COPS6	cops4	ENSTRUP00000065015	ENSTRUP00000053695	COP9 signalosome subunit 6.	COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis).	0.999
COPS6	eif3h	ENSTRUP00000065015	ENSTRUP00000018353	COP9 signalosome subunit 6.	Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.883
COPS6	mysm1	ENSTRUP00000065015	ENSTRUP00000041996	COP9 signalosome subunit 6.	Histone H2A deubiquitinase MYSM1.	0.580
COPS6	psmd14	ENSTRUP00000065015	ENSTRUP00000043942	COP9 signalosome subunit 6.	Proteasome 26S subunit, non-ATPase 14.	0.550
COPS6	psmd7	ENSTRUP00000065015	ENSTRUP00000055135	COP9 signalosome subunit 6.	Proteasome 26S subunit, non-ATPase 7.	0.471
COPS6	senp8	ENSTRUP00000065015	ENSTRUP00000042170	COP9 signalosome subunit 6.	SUMO peptidase family member, NEDD8 specific.	0.482
COPS6	uchl5	ENSTRUP00000065015	ENSTRUP00000054996	COP9 signalosome subunit 6.	Ubiquitin carboxyl-terminal hydrolase.	0.671
COPS6	usp14	ENSTRUP00000065015	ENSTRUP00000054871	COP9 signalosome subunit 6.	Ubiquitin carboxyl-terminal hydrolase.	0.671
EIF3F	COPS6	ENSTRUP00000084787	ENSTRUP00000065015	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	COP9 signalosome subunit 6.	0.543
EIF3F	arfgef1-2	ENSTRUP00000084787	ENSTRUP00000070411	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited).	0.701
EIF3F	bap1	ENSTRUP00000084787	ENSTRUP00000035472	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Ubiquitin carboxyl-terminal hydrolase.	0.672
EIF3F	cops4	ENSTRUP00000084787	ENSTRUP00000053695	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis).	0.901
EIF3F	eif3h	ENSTRUP00000084787	ENSTRUP00000018353	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.999
EIF3F	mpnd	ENSTRUP00000084787	ENSTRUP00000003964	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	MPN domain containing.	0.527
EIF3F	mysm1	ENSTRUP00000084787	ENSTRUP00000041996	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Histone H2A deubiquitinase MYSM1.	0.587
EIF3F	psmd14	ENSTRUP00000084787	ENSTRUP00000043942	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Proteasome 26S subunit, non-ATPase 14.	0.619
EIF3F	senp8	ENSTRUP00000084787	ENSTRUP00000042170	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	SUMO peptidase family member, NEDD8 specific.	0.453