(27 nodes) CD4-positive, alpha-beta T cell activation network (Takifugu rubripes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rc3h1	Ring finger and CCCH-type domains 1b. (1123 aa)
	LOC101062726	Uncharacterized protein. (660 aa)
	card11	Uncharacterized protein. (1153 aa)
	il6r	Fibronectin type-III domain-containing protein. (539 aa)
	Rc3h2	Ring finger and CCCH-type domains 2. (1042 aa)
	NKX2-3	Homeobox domain-containing protein. (352 aa)
	H2SAI0_TAKRU	Receptor-interacting serine-threonine kinase 2. (554 aa)
	hlx	H2.0-like homeo box 1 (Drosophila). (381 aa)
	LOC101079551	Prostaglandin E receptor 4 (subtype EP4) c; Belongs to the G-protein coupled receptor 1 family. (464 aa)
	il-6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (227 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2554 aa)
	il12b	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (359 aa)
	il2rg	Cytokine receptor gamma chain. (315 aa)
	sash3	SAM and SH3 domain containing 3. (377 aa)
	LOC101065046	G protein-coupled receptor 183a; Belongs to the G-protein coupled receptor 1 family. (371 aa)
	LOC101061475	E3 ubiquitin-protein ligase. (879 aa)
	LOC101074394	Si:ch211-184m13.4; Belongs to the G-protein coupled receptor 1 family. (339 aa)
	tbx21	T-box transcription factor 21. (616 aa)
	LOC101070091	Prostaglandin E receptor 4 (subtype EP4) a; Belongs to the G-protein coupled receptor 1 family. (439 aa)
	tmem98	Transmembrane protein 98. (224 aa)
	LOC101070007	E3 ubiquitin-protein ligase. (818 aa)
	armc5	Armadillo repeat containing 5. (1237 aa)
	nkx2-3	NK2 homeobox 3. (333 aa)
	cd83	Ig-like domain-containing protein. (215 aa)
	LOC101076344	Prostaglandin E receptor 4 (subtype EP4) b. (430 aa)
	lef1	Lymphoid enhancer-binding factor 1. (377 aa)
	batf	Basic leucine zipper transcription factor, ATF-like. (140 aa)

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H2SAI0_TAKRU	LOC101061475	ENSTRUP00000009406	ENSTRUP00000029093	Receptor-interacting serine-threonine kinase 2.	E3 ubiquitin-protein ligase.	0.529
H2SAI0_TAKRU	LOC101070007	ENSTRUP00000009406	ENSTRUP00000047199	Receptor-interacting serine-threonine kinase 2.	E3 ubiquitin-protein ligase.	0.529
H2SAI0_TAKRU	card11	ENSTRUP00000009406	ENSTRUP00000004660	Receptor-interacting serine-threonine kinase 2.	Uncharacterized protein.	0.567
LOC101061475	H2SAI0_TAKRU	ENSTRUP00000029093	ENSTRUP00000009406	E3 ubiquitin-protein ligase.	Receptor-interacting serine-threonine kinase 2.	0.529
LOC101070007	H2SAI0_TAKRU	ENSTRUP00000047199	ENSTRUP00000009406	E3 ubiquitin-protein ligase.	Receptor-interacting serine-threonine kinase 2.	0.529
Rc3h2	rc3h1	ENSTRUP00000007866	ENSTRUP00000020897	Ring finger and CCCH-type domains 2.	Ring finger and CCCH-type domains 1b.	0.646
card11	H2SAI0_TAKRU	ENSTRUP00000004660	ENSTRUP00000009406	Uncharacterized protein.	Receptor-interacting serine-threonine kinase 2.	0.567
cd83	tbx21	ENSTRUP00000056962	ENSTRUP00000032966	Ig-like domain-containing protein.	T-box transcription factor 21.	0.466
hlx	tbx21	ENSTRUP00000016589	ENSTRUP00000032966	H2.0-like homeo box 1 (Drosophila).	T-box transcription factor 21.	0.571
il-6	il12b	ENSTRUP00000021936	ENSTRUP00000022864	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily.	0.424
il-6	il6r	ENSTRUP00000021936	ENSTRUP00000007361	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	Fibronectin type-III domain-containing protein.	0.900
il12b	il-6	ENSTRUP00000022864	ENSTRUP00000021936	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.424
il6r	il-6	ENSTRUP00000007361	ENSTRUP00000021936	Fibronectin type-III domain-containing protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.900
rc3h1	Rc3h2	ENSTRUP00000020897	ENSTRUP00000007866	Ring finger and CCCH-type domains 1b.	Ring finger and CCCH-type domains 2.	0.646
tbx21	cd83	ENSTRUP00000032966	ENSTRUP00000056962	T-box transcription factor 21.	Ig-like domain-containing protein.	0.466
tbx21	hlx	ENSTRUP00000032966	ENSTRUP00000016589	T-box transcription factor 21.	H2.0-like homeo box 1 (Drosophila).	0.571