(87 nodes) Positive regulation of I-kappaB kinase/NF-kappaB signaling network (Takifugu rubripes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PRKCB	Non-specific serine/threonine protein kinase. (682 aa)
	prkn	Ubiquitin-like domain-containing protein. (532 aa)
	LOC101064815	Protein kinase C. (687 aa)
	abl1	Tyrosine-protein kinase. (1115 aa)
	LOC101067067	DED domain-containing protein. (196 aa)
	sharpin	SHANK-associated RH domain interacting protein. (493 aa)
	ENSTRUP00000058480	Uncharacterized protein LOC105418817 isoform X2. (126 aa)
	ENSTRUP00000056963	annotation not available (197 aa)
	LURAP1L	Uncharacterized protein. (298 aa)
	Trim32	Tripartite motif containing 32. (653 aa)
	LOC101065618	E3 ubiquitin-protein ligase RNF31-like isoform X1. (704 aa)
	LOC101066734	SEFIR domain-containing protein. (432 aa)
	LOC101080086	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (266 aa)
	myd88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (288 aa)
	LOC101070086	Innate immunity activator b. (594 aa)
	ccl19	SCY domain-containing protein. (113 aa)
	irak4	Interleukin-1 receptor-associated kinase 4. (460 aa)
	alpk1	Alpha kinase 1. (1063 aa)
	LOC101074300	Fas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family. (260 aa)
	trim8	Tripartite motif containing 8b. (590 aa)
	tradd	Tnfrsf1a-associated via death domain. (305 aa)
	rnf31	Uncharacterized protein. (1091 aa)
	tnfa	Tumor necrosis factor alpha. (250 aa)
	map3k7	Mitogen-activated protein kinase kinase kinase 7. (604 aa)
	f2r	Coagulation factor II (thrombin) receptor; Belongs to the G-protein coupled receptor 1 family. (413 aa)
	tnfrsf1a	Tumor necrosis factor receptor superfamily member 1A. (378 aa)
	LOC101075588	Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	LOC115247907	Si:dkey-181m9.8. (704 aa)
	H2SAI0_TAKRU	Receptor-interacting serine-threonine kinase 2. (554 aa)
	gapdh	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	ENSTRUP00000005140	TANK-binding kinase 1. (603 aa)
	card11	Uncharacterized protein. (1153 aa)
	dhx36	DEAH (Asp-Glu-Ala-His) box polypeptide 36. (1046 aa)
	JMJD8	Jumonji domain containing 8. (264 aa)
	tmem101	Transmembrane protein 101. (280 aa)
	gprc5b	G protein-coupled receptor, class C, group 5, member Ba. (403 aa)
	ddx1	DEAD (Asp-Glu-Ala-Asp) box helicase 1. (739 aa)
	terf2ip	Uncharacterized protein. (132 aa)
	H2UM47_TAKRU	Uncharacterized protein. (134 aa)
	LOC101064351	Tripartite motif containing 62, tandem duplicate 1. (475 aa)
	LOC101070473	Mitochondrial E3 ubiquitin protein ligase 1a. (357 aa)
	LOC101068369	Mitogen-activated protein kinase kinase kinase 14a. (887 aa)
	DHX15	DEAH-box helicase 15. (337 aa)
	cflar	Uncharacterized protein; Belongs to the peptidase C14A family. (470 aa)
	rbck1	RanBP-type and C3HC4-type zinc finger containing 1. (517 aa)
	H2TV94_TAKRU	Uncharacterized protein. (97 aa)
	Tifa	Si:ch211-15b10.6. (193 aa)
	MTDH	Uncharacterized protein. (525 aa)
	LOC101068646	E3 ubiquitin-protein ligase RNF31-like. (1147 aa)
	casp8	Uncharacterized protein; Belongs to the peptidase C14A family. (526 aa)
	LOC101065234	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
	pink1	PTEN induced kinase 1. (568 aa)
	cd40	CD40. (307 aa)
	tab2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (748 aa)
	mul1	Mitochondrial E3 ubiquitin protein ligase 1b. (352 aa)
	tirap	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein. (180 aa)
	abl2	Tyrosine-protein kinase. (1214 aa)
	LOC101064776	Uncharacterized protein. (86 aa)
	tnip2	TNFAIP3 interacting protein 2. (479 aa)
	ENSTRUP00000071660	annotation not available (225 aa)
	gapdh-2	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	tnfrsf1a-2	Tumor necrosis factor receptor superfamily, member 1a. (378 aa)
	tab3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (600 aa)
	LOC101061322	Caspase 10, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (540 aa)
	ikbkb	Inhibitor of nuclear factor kappa B kinase subunit beta. (736 aa)
	LOC101078784	Uncharacterized protein. (1343 aa)
	LOC101067596	Mitogen-activated protein kinase kinase kinase 14. (933 aa)
	LOC101076668	G protein-coupled receptor, class C, group 5, member Bb. (419 aa)
	ikbke	Protein kinase domain-containing protein. (721 aa)
	LOC101064989	Sharpin and rbck1 related. (710 aa)
	ddx21	DEAD (Asp-Glu-Ala-Asp) box helicase 21. (747 aa)
	LOC101068225	Component of inhibitor of nuclear factor kappa B kinase complex. (741 aa)
	ENSTRUP00000081861	annotation not available (181 aa)
	cth	Cystathionase (cystathionine gamma-lyase), like. (410 aa)
	LOC101072729	Leucine rich adaptor protein 1. (340 aa)
	ENSTRUP00000084024	annotation not available (223 aa)
	ENSTRUP00000084862	Protein kinase C, alpha, b. (340 aa)
	LOC101079823	Classical protein kinase C gamma type. (700 aa)
	LOC105418159	Leucine rich adaptor protein 1-like. (336 aa)
	edar	Ectodysplasin A receptor. (515 aa)
	ajuba	Ajuba LIM protein. (767 aa)
	inava	Innate immunity activator a. (562 aa)
	tnfsf10	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (319 aa)
	LOC101061335	Bromodomain containing 4. (1553 aa)
	nod2	CARD15. (998 aa)
	traf3ip2	SEFIR domain-containing protein. (112 aa)
	nod1	Nucleotide-binding oligomerization domain containing 1. (946 aa)

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DHX15	ENSTRUP00000084024	ENSTRUP00000035776	ENSTRUP00000084024	DEAH-box helicase 15.	annotation not available	0.885
DHX15	ddx1	ENSTRUP00000035776	ENSTRUP00000040282	DEAH-box helicase 15.	DEAD (Asp-Glu-Ala-Asp) box helicase 1.	0.808
DHX15	ddx21	ENSTRUP00000035776	ENSTRUP00000079783	DEAH-box helicase 15.	DEAD (Asp-Glu-Ala-Asp) box helicase 21.	0.827
DHX15	dhx36	ENSTRUP00000035776	ENSTRUP00000002858	DEAH-box helicase 15.	DEAH (Asp-Glu-Ala-His) box polypeptide 36.	0.401
ENSTRUP00000005140	LOC101064989	ENSTRUP00000005140	ENSTRUP00000079758	TANK-binding kinase 1.	Sharpin and rbck1 related.	0.440
ENSTRUP00000005140	LOC101065618	ENSTRUP00000005140	ENSTRUP00000053132	TANK-binding kinase 1.	E3 ubiquitin-protein ligase RNF31-like isoform X1.	0.700
ENSTRUP00000005140	LOC101067596	ENSTRUP00000005140	ENSTRUP00000069256	TANK-binding kinase 1.	Mitogen-activated protein kinase kinase kinase 14.	0.419
ENSTRUP00000005140	LOC101068369	ENSTRUP00000005140	ENSTRUP00000036335	TANK-binding kinase 1.	Mitogen-activated protein kinase kinase kinase 14a.	0.419
ENSTRUP00000005140	LOC101068646	ENSTRUP00000005140	ENSTRUP00000024863	TANK-binding kinase 1.	E3 ubiquitin-protein ligase RNF31-like.	0.700
ENSTRUP00000005140	LOC115247907	ENSTRUP00000005140	ENSTRUP00000010647	TANK-binding kinase 1.	Si:dkey-181m9.8.	0.700
ENSTRUP00000005140	myd88	ENSTRUP00000005140	ENSTRUP00000050655	TANK-binding kinase 1.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.750
ENSTRUP00000005140	rbck1	ENSTRUP00000005140	ENSTRUP00000029671	TANK-binding kinase 1.	RanBP-type and C3HC4-type zinc finger containing 1.	0.440
ENSTRUP00000005140	rnf31	ENSTRUP00000005140	ENSTRUP00000045452	TANK-binding kinase 1.	Uncharacterized protein.	0.700
ENSTRUP00000005140	sharpin	ENSTRUP00000005140	ENSTRUP00000059976	TANK-binding kinase 1.	SHANK-associated RH domain interacting protein.	0.433
ENSTRUP00000005140	tab2	ENSTRUP00000005140	ENSTRUP00000019221	TANK-binding kinase 1.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.602
ENSTRUP00000005140	tab3	ENSTRUP00000005140	ENSTRUP00000045324	TANK-binding kinase 1.	TGF-beta activated kinase 1 (MAP3K7) binding protein 3.	0.602
ENSTRUP00000005140	tirap	ENSTRUP00000005140	ENSTRUP00000017584	TANK-binding kinase 1.	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein.	0.578
ENSTRUP00000005140	tnfrsf1a	ENSTRUP00000005140	ENSTRUP00000011080	TANK-binding kinase 1.	Tumor necrosis factor receptor superfamily member 1A.	0.746
ENSTRUP00000005140	tnfrsf1a-2	ENSTRUP00000005140	ENSTRUP00000074097	TANK-binding kinase 1.	Tumor necrosis factor receptor superfamily, member 1a.	0.746
ENSTRUP00000005140	tradd	ENSTRUP00000005140	ENSTRUP00000046064	TANK-binding kinase 1.	Tnfrsf1a-associated via death domain.	0.656