(14 nodes) Regulation of cholesterol biosynthetic process network (Takifugu rubripes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	apoe2	Apolipoprotein E2. (276 aa)
	srebf1	Sterol regulatory element binding transcription factor 1. (1167 aa)
	apoe1	Uncharacterized protein. (247 aa)
	LOC101073042	ATP-binding cassette, sub-family G (WHITE), member 4b. (634 aa)
	scap	SREBF chaperone. (1272 aa)
	H2RM54_TAKRU	Vitellogenin domain-containing protein. (726 aa)
	ENSTRUP00000074430	annotation not available (262 aa)
	lpcat3	Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (465 aa)
	LOC101069995	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (154 aa)
	ENSTRUP00000078597	Lysophosphatidylcholine acyltransferase 3. (452 aa)
	srebf2	Sterol regulatory element binding transcription factor 2. (1172 aa)
	ENSTRUP00000084559	ATP-binding cassette, subfamily G (WHITE), member 1. (666 aa)
	abcg4	ATP-binding cassette, sub-family G (WHITE), member 4a. (643 aa)
	LOC101066818	Apolipoprotein Bb, tandem duplicate 2. (3788 aa)

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSTRUP00000074430	apoe1	ENSTRUP00000074430	ENSTRUP00000030259	annotation not available	Uncharacterized protein.	0.710
ENSTRUP00000074430	apoe2	ENSTRUP00000074430	ENSTRUP00000074375	annotation not available	Apolipoprotein E2.	0.768
ENSTRUP00000084559	srebf2	ENSTRUP00000084559	ENSTRUP00000080294	ATP-binding cassette, subfamily G (WHITE), member 1.	Sterol regulatory element binding transcription factor 2.	0.503
H2RM54_TAKRU	apoe1	ENSTRUP00000001217	ENSTRUP00000030259	Vitellogenin domain-containing protein.	Uncharacterized protein.	0.710
H2RM54_TAKRU	apoe2	ENSTRUP00000001217	ENSTRUP00000074375	Vitellogenin domain-containing protein.	Apolipoprotein E2.	0.768
LOC101066818	apoe1	ENSTRUP00000087964	ENSTRUP00000030259	Apolipoprotein Bb, tandem duplicate 2.	Uncharacterized protein.	0.710
LOC101066818	apoe2	ENSTRUP00000087964	ENSTRUP00000074375	Apolipoprotein Bb, tandem duplicate 2.	Apolipoprotein E2.	0.768
LOC101073042	abcg4	ENSTRUP00000010849	ENSTRUP00000087724	ATP-binding cassette, sub-family G (WHITE), member 4b.	ATP-binding cassette, sub-family G (WHITE), member 4a.	0.901
abcg4	LOC101073042	ENSTRUP00000087724	ENSTRUP00000010849	ATP-binding cassette, sub-family G (WHITE), member 4a.	ATP-binding cassette, sub-family G (WHITE), member 4b.	0.901
apoe1	ENSTRUP00000074430	ENSTRUP00000030259	ENSTRUP00000074430	Uncharacterized protein.	annotation not available	0.710
apoe1	H2RM54_TAKRU	ENSTRUP00000030259	ENSTRUP00000001217	Uncharacterized protein.	Vitellogenin domain-containing protein.	0.710
apoe1	LOC101066818	ENSTRUP00000030259	ENSTRUP00000087964	Uncharacterized protein.	Apolipoprotein Bb, tandem duplicate 2.	0.710
apoe1	srebf1	ENSTRUP00000030259	ENSTRUP00000020514	Uncharacterized protein.	Sterol regulatory element binding transcription factor 1.	0.431
apoe2	ENSTRUP00000074430	ENSTRUP00000074375	ENSTRUP00000074430	Apolipoprotein E2.	annotation not available	0.768
apoe2	H2RM54_TAKRU	ENSTRUP00000074375	ENSTRUP00000001217	Apolipoprotein E2.	Vitellogenin domain-containing protein.	0.768
apoe2	LOC101066818	ENSTRUP00000074375	ENSTRUP00000087964	Apolipoprotein E2.	Apolipoprotein Bb, tandem duplicate 2.	0.768
apoe2	srebf1	ENSTRUP00000074375	ENSTRUP00000020514	Apolipoprotein E2.	Sterol regulatory element binding transcription factor 1.	0.438
scap	srebf1	ENSTRUP00000004123	ENSTRUP00000020514	SREBF chaperone.	Sterol regulatory element binding transcription factor 1.	0.951
scap	srebf2	ENSTRUP00000004123	ENSTRUP00000080294	SREBF chaperone.	Sterol regulatory element binding transcription factor 2.	0.951
srebf1	apoe1	ENSTRUP00000020514	ENSTRUP00000030259	Sterol regulatory element binding transcription factor 1.	Uncharacterized protein.	0.431