(14 nodes) Regulation of membrane protein ectodomain proteolysis network (Takifugu rubripes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H2VAJ3_TAKRU	Peptidase_M16_C domain-containing protein. (1087 aa)
	LOC101079111	Uncharacterized protein. (1027 aa)
	il1b	Interleukin-1; Belongs to the IL-1 family. (256 aa)
	LOC101064303	Nardilysin a (N-arginine dibasic convertase); Belongs to the peptidase M16 family. (971 aa)
	timp-2b	NTR domain-containing protein. (219 aa)
	apoe1	Uncharacterized protein. (247 aa)
	tnfrsf14	Tumor necrosis factor receptor superfamily, member 1B. (489 aa)
	sh3d19	SH3 domain containing 19. (367 aa)
	apoe2	Apolipoprotein E2. (276 aa)
	snx9	Sorting nexin. (626 aa)
	il10	Interleukin 10. (227 aa)
	timp3	NTR domain-containing protein. (214 aa)
	timp4	TIMP metallopeptidase inhibitor 4, tandem duplicate 2. (224 aa)
	timp2	Tissue inhibitor of metalloproteinase 2a. (220 aa)

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
apoe1	il10	ENSTRUP00000030259	ENSTRUP00000054385	Uncharacterized protein.	Interleukin 10.	0.419
apoe2	il10	ENSTRUP00000074375	ENSTRUP00000054385	Apolipoprotein E2.	Interleukin 10.	0.576
apoe2	il1b	ENSTRUP00000074375	ENSTRUP00000040920	Apolipoprotein E2.	Interleukin-1; Belongs to the IL-1 family.	0.512
il10	apoe1	ENSTRUP00000054385	ENSTRUP00000030259	Interleukin 10.	Uncharacterized protein.	0.419
il10	apoe2	ENSTRUP00000054385	ENSTRUP00000074375	Interleukin 10.	Apolipoprotein E2.	0.576
il10	il1b	ENSTRUP00000054385	ENSTRUP00000040920	Interleukin 10.	Interleukin-1; Belongs to the IL-1 family.	0.915
il10	timp-2b	ENSTRUP00000054385	ENSTRUP00000028366	Interleukin 10.	NTR domain-containing protein.	0.506
il10	timp2	ENSTRUP00000054385	ENSTRUP00000046417	Interleukin 10.	Tissue inhibitor of metalloproteinase 2a.	0.506
il10	timp3	ENSTRUP00000054385	ENSTRUP00000053203	Interleukin 10.	NTR domain-containing protein.	0.448
il10	timp4	ENSTRUP00000054385	ENSTRUP00000047892	Interleukin 10.	TIMP metallopeptidase inhibitor 4, tandem duplicate 2.	0.448
il10	tnfrsf14	ENSTRUP00000054385	ENSTRUP00000037805	Interleukin 10.	Tumor necrosis factor receptor superfamily, member 1B.	0.530
il1b	apoe2	ENSTRUP00000040920	ENSTRUP00000074375	Interleukin-1; Belongs to the IL-1 family.	Apolipoprotein E2.	0.512
il1b	il10	ENSTRUP00000040920	ENSTRUP00000054385	Interleukin-1; Belongs to the IL-1 family.	Interleukin 10.	0.915
il1b	tnfrsf14	ENSTRUP00000040920	ENSTRUP00000037805	Interleukin-1; Belongs to the IL-1 family.	Tumor necrosis factor receptor superfamily, member 1B.	0.610
timp-2b	il10	ENSTRUP00000028366	ENSTRUP00000054385	NTR domain-containing protein.	Interleukin 10.	0.506
timp-2b	timp3	ENSTRUP00000028366	ENSTRUP00000053203	NTR domain-containing protein.	NTR domain-containing protein.	0.494
timp2	il10	ENSTRUP00000046417	ENSTRUP00000054385	Tissue inhibitor of metalloproteinase 2a.	Interleukin 10.	0.506
timp2	timp3	ENSTRUP00000046417	ENSTRUP00000053203	Tissue inhibitor of metalloproteinase 2a.	NTR domain-containing protein.	0.508
timp3	il10	ENSTRUP00000053203	ENSTRUP00000054385	NTR domain-containing protein.	Interleukin 10.	0.448
timp3	timp-2b	ENSTRUP00000053203	ENSTRUP00000028366	NTR domain-containing protein.	NTR domain-containing protein.	0.494