(73 nodes) Regulation of sequestering of calcium ion network (Takifugu rubripes)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ccl19	SCY domain-containing protein. (113 aa)
	atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	ibtk	Inhibitor of Bruton agammaglobulinemia tyrosine kinase. (1362 aa)
	ptprc	Uncharacterized protein. (1248 aa)
	mcoln1	Mucolipin 1a. (562 aa)
	LOC101072908	Peptidylprolyl isomerase. (109 aa)
	ENSTRUP00000008077	Calmodulin 1b. (175 aa)
	ENSTRUP00000008078	Junctophilin 1a. (699 aa)
	f2r	Coagulation factor II (thrombin) receptor; Belongs to the G-protein coupled receptor 1 family. (413 aa)
	LOC101064053	Apelin receptor a; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	f2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (648 aa)
	itpr2	Inositol 1,4,5-trisphosphate receptor, type 2. (2679 aa)
	H2SSV6_TAKRU	Apelin receptor b; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	H2SVD9_TAKRU	Ion_trans domain-containing protein. (727 aa)
	plcg2	Phosphoinositide phospholipase C. (1248 aa)
	cherp	Calcium homeostasis endoplasmic reticulum protein. (928 aa)
	H2T1L2_TAKRU	Glycoprotein IX (platelet). (272 aa)
	p2rx7	Purinergic receptor P2X, ligand-gated ion channel, 7. (577 aa)
	clic2	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (245 aa)
	LOC101070744	Grancalcin. (337 aa)
	jph2	Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (769 aa)
	LOC101074739	Inositol 1,4,5-trisphosphate receptor, type 1a. (2743 aa)
	LOC101071755	Uncharacterized protein. (2728 aa)
	pkd2	Polycystic kidney disease 2. (901 aa)
	LOC101062358	Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (673 aa)
	LOC101078025	Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (848 aa)
	LOC101077892	Chemokine (C motif) receptor 1b, duplicate 1; Belongs to the G-protein coupled receptor 1 family. (369 aa)
	LOC101069310	Two pore segment channel 3. (730 aa)
	STAC3	SH3 and cysteine rich domain 3. (337 aa)
	H2USA3_TAKRU	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (414 aa)
	LOC101067761	SH3 and cysteine rich domain 3. (332 aa)
	tpcn1	Two pore segment channel 1. (825 aa)
	LOC101067574	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
	letm2	Leucine zipper-EF-hand containing transmembrane protein 2. (509 aa)
	htr2b	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled. (471 aa)
	mcoln2	Mucolipin 2. (553 aa)
	p22phox	Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (186 aa)
	MCOLN3	PKD_channel domain-containing protein. (560 aa)
	LOC101074300	Fas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family. (260 aa)
	wnt5a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	MTLN	Mitoregulin. (56 aa)
	LOC101072775	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1. (580 aa)
	ddit3	DNA-damage-inducible transcript 3. (309 aa)
	LOC101077453	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (432 aa)
	LOC101066300	Opsin 4.1. (463 aa)
	ENSTRUP00000052460	Ins145_P3_rec domain-containing protein. (206 aa)
	bax	BCL2 associated X, apoptosis regulator a. (193 aa)
	pln	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (53 aa)
	SLC8B1	Solute carrier family 8 member B1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (589 aa)
	calm2	Calmodulin 2a (phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
	fkbp1b	Peptidylprolyl isomerase. (108 aa)
	LOC101066788	Uncharacterized protein. (170 aa)
	ENSTRUP00000055369	Uncharacterized protein. (109 aa)
	lime1	Uncharacterized protein. (532 aa)
	akap6	A-kinase anchor protein 6. (1867 aa)
	calm2-2	Calmodulin 3. (149 aa)
	plcg1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1314 aa)
	ENSTRUP00000058474	annotation not available (159 aa)
	ENSTRUP00000060234	annotation not available (527 aa)
	LOC101061700	Uncharacterized protein. (149 aa)
	jph3	Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (789 aa)
	trpc1	Transient receptor potential cation channel, subfamily C, member 1; Belongs to the transient receptor (TC 1.A.4) family. (797 aa)
	htt	Huntingtin; May play a role in microtubule-mediated transport or vesicle function. (3170 aa)
	ENSTRUP00000062034	annotation not available (175 aa)
	LOC101070433	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (427 aa)
	LOC101061703	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (441 aa)
	LOC101065481	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like. (1307 aa)
	LOC101064505	Uncharacterized protein; Belongs to the calmodulin family. (317 aa)
	trpa1	Transient receptor potential cation channel, subfamily A, member 1b; Belongs to the transient receptor (TC 1.A.4) family. (1133 aa)
	letm1	Leucine zipper-EF-hand containing transmembrane protein 1. (781 aa)
	ENSTRUP00000083056	Trichohyalin-like isoform X1. (2031 aa)
	CXCR3	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	anxa6	Annexin. (667 aa)

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CXCR3	ccl19	ENSTRUP00000083358	ENSTRUP00000050152	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	SCY domain-containing protein.	0.618
ENSTRUP00000008077	LOC101069310	ENSTRUP00000008077	ENSTRUP00000035068	Calmodulin 1b.	Two pore segment channel 3.	0.408
ENSTRUP00000008077	LOC101072908	ENSTRUP00000008077	ENSTRUP00000007077	Calmodulin 1b.	Peptidylprolyl isomerase.	0.723
ENSTRUP00000008077	fkbp1b	ENSTRUP00000008077	ENSTRUP00000054494	Calmodulin 1b.	Peptidylprolyl isomerase.	0.723
ENSTRUP00000008077	tpcn1	ENSTRUP00000008077	ENSTRUP00000041491	Calmodulin 1b.	Two pore segment channel 1.	0.408
ENSTRUP00000052460	LOC101065481	ENSTRUP00000052460	ENSTRUP00000077824	Ins145_P3_rec domain-containing protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like.	0.923
ENSTRUP00000052460	calm2	ENSTRUP00000052460	ENSTRUP00000054207	Ins145_P3_rec domain-containing protein.	Calmodulin 2a (phosphorylase kinase, delta); Belongs to the calmodulin family.	0.927
ENSTRUP00000052460	plcg1	ENSTRUP00000052460	ENSTRUP00000058192	Ins145_P3_rec domain-containing protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.923
ENSTRUP00000052460	plcg2	ENSTRUP00000052460	ENSTRUP00000017918	Ins145_P3_rec domain-containing protein.	Phosphoinositide phospholipase C.	0.923
ENSTRUP00000062034	LOC101061700	ENSTRUP00000062034	ENSTRUP00000060286	annotation not available	Uncharacterized protein.	0.506
ENSTRUP00000062034	LOC101061703	ENSTRUP00000062034	ENSTRUP00000076810	annotation not available	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.494
ENSTRUP00000062034	LOC101070433	ENSTRUP00000062034	ENSTRUP00000076592	annotation not available	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.494
ENSTRUP00000062034	LOC101072908	ENSTRUP00000062034	ENSTRUP00000007077	annotation not available	Peptidylprolyl isomerase.	0.494
ENSTRUP00000062034	LOC101077453	ENSTRUP00000062034	ENSTRUP00000050283	annotation not available	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.494
ENSTRUP00000062034	fkbp1b	ENSTRUP00000062034	ENSTRUP00000054494	annotation not available	Peptidylprolyl isomerase.	0.494
ENSTRUP00000083056	LOC101061700	ENSTRUP00000083056	ENSTRUP00000060286	Trichohyalin-like isoform X1.	Uncharacterized protein.	0.643
ENSTRUP00000083056	LOC101061703	ENSTRUP00000083056	ENSTRUP00000076810	Trichohyalin-like isoform X1.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.617
ENSTRUP00000083056	LOC101070433	ENSTRUP00000083056	ENSTRUP00000076592	Trichohyalin-like isoform X1.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.617
ENSTRUP00000083056	LOC101072908	ENSTRUP00000083056	ENSTRUP00000007077	Trichohyalin-like isoform X1.	Peptidylprolyl isomerase.	0.645
ENSTRUP00000083056	LOC101077453	ENSTRUP00000083056	ENSTRUP00000050283	Trichohyalin-like isoform X1.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.617