(18 nodes) NAD+ binding network (Takifugu rubripes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101073415	Poly [ADP-ribose] polymerase. (1776 aa)
	LOC105417439	Zgc:56585; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (257 aa)
	LOC101066119	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (431 aa)
	hadha	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b; Belongs to the enoyl-CoA hydratase/isomerase family. (764 aa)
	sirt3	Sirtuin 3. (340 aa)
	SIRT5	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (302 aa)
	sirt4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (310 aa)
	sirt1	Sirtuin 1. (689 aa)
	sirt2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (377 aa)
	hpgd	15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (261 aa)
	hadh	Hydroxyacyl-CoA dehydrogenase. (313 aa)
	sirt7	Sirtuin 7. (434 aa)
	LOC101079237	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (257 aa)
	ehhadh	Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (746 aa)
	LOC101068877	Poly [ADP-ribose] polymerase. (1853 aa)
	uxs1	UDP-glucuronate decarboxylase 1. (418 aa)
	sirt6	Sirtuin 6. (371 aa)
	cryl1	Crystallin, lambda 1. (317 aa)

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101066119	SIRT5	ENSTRUP00000023582	ENSTRUP00000031548	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.610
LOC101066119	sirt1	ENSTRUP00000023582	ENSTRUP00000046065	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	Sirtuin 1.	0.670
LOC101066119	sirt4	ENSTRUP00000023582	ENSTRUP00000038866	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.538
SIRT5	LOC101066119	ENSTRUP00000031548	ENSTRUP00000023582	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.610
SIRT5	sirt2	ENSTRUP00000031548	ENSTRUP00000049231	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.775
SIRT5	sirt3	ENSTRUP00000031548	ENSTRUP00000031533	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Sirtuin 3.	0.668
SIRT5	sirt4	ENSTRUP00000031548	ENSTRUP00000038866	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.621
SIRT5	sirt6	ENSTRUP00000031548	ENSTRUP00000078257	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Sirtuin 6.	0.852
SIRT5	sirt7	ENSTRUP00000031548	ENSTRUP00000052825	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Sirtuin 7.	0.858
cryl1	ehhadh	ENSTRUP00000084210	ENSTRUP00000068391	Crystallin, lambda 1.	Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.578
cryl1	hadha	ENSTRUP00000084210	ENSTRUP00000027738	Crystallin, lambda 1.	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b; Belongs to the enoyl-CoA hydratase/isomerase family.	0.545
ehhadh	cryl1	ENSTRUP00000068391	ENSTRUP00000084210	Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	Crystallin, lambda 1.	0.578
ehhadh	hadh	ENSTRUP00000068391	ENSTRUP00000051920	Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	Hydroxyacyl-CoA dehydrogenase.	0.968
ehhadh	hadha	ENSTRUP00000068391	ENSTRUP00000027738	Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b; Belongs to the enoyl-CoA hydratase/isomerase family.	0.937
hadh	ehhadh	ENSTRUP00000051920	ENSTRUP00000068391	Hydroxyacyl-CoA dehydrogenase.	Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.968
hadh	hadha	ENSTRUP00000051920	ENSTRUP00000027738	Hydroxyacyl-CoA dehydrogenase.	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b; Belongs to the enoyl-CoA hydratase/isomerase family.	0.967
hadha	cryl1	ENSTRUP00000027738	ENSTRUP00000084210	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b; Belongs to the enoyl-CoA hydratase/isomerase family.	Crystallin, lambda 1.	0.545
hadha	ehhadh	ENSTRUP00000027738	ENSTRUP00000068391	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b; Belongs to the enoyl-CoA hydratase/isomerase family.	Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.937
hadha	hadh	ENSTRUP00000027738	ENSTRUP00000051920	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b; Belongs to the enoyl-CoA hydratase/isomerase family.	Hydroxyacyl-CoA dehydrogenase.	0.967
sirt1	LOC101066119	ENSTRUP00000046065	ENSTRUP00000023582	Sirtuin 1.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.670