(25 nodes) K63-linked polyubiquitin modification-dependent protein binding network (Takifugu rubripes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	optn	Optineurin. (540 aa)
	ENSTRUP00000088466	SprT-like N-terminal domain. (244 aa)
	LOC101067616	OTU deubiquitinase 7A. (955 aa)
	LOC101074386	Sequestosome 1. (458 aa)
	st3gal1	Alpha-2,3-sialyltransferase ST3Gal I; Belongs to the glycosyltransferase 29 family. (1368 aa)
	ENSTRUP00000074749	annotation not available (128 aa)
	sprtn	SprT-like N-terminal domain. (244 aa)
	tnip2	TNFAIP3 interacting protein 2. (479 aa)
	rnf169	Ring finger protein 169. (543 aa)
	RNF168	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (128 aa)
	LOC101065618	E3 ubiquitin-protein ligase RNF31-like isoform X1. (704 aa)
	ENSTRUP00000049325	GSAP-16 domain-containing protein. (159 aa)
	tnfaip3	Tumor necrosis factor, alpha-induced protein 3. (823 aa)
	rnf31	Uncharacterized protein. (1091 aa)
	tab3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (600 aa)
	prpf8	Pre-mRNA processing factor 8. (2338 aa)
	otud7b	OTU deubiquitinase 7B. (926 aa)
	zranb3	Zinc finger, RAN-binding domain containing 3. (1134 aa)
	LOC101068646	E3 ubiquitin-protein ligase RNF31-like. (1147 aa)
	ZRANB1	Zinc finger RANBP2-type containing 1. (718 aa)
	tab2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (748 aa)
	zbtb1	Zinc finger and BTB domain containing 1. (668 aa)
	LOC115247907	Si:dkey-181m9.8. (704 aa)
	atrip	Uncharacterized protein. (739 aa)
	LOC101077697	Zinc finger, RAN-binding domain containing 1b. (755 aa)

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSTRUP00000049325	optn	ENSTRUP00000049325	ENSTRUP00000026229	GSAP-16 domain-containing protein.	Optineurin.	0.593
ENSTRUP00000074749	rnf169	ENSTRUP00000074749	ENSTRUP00000066006	annotation not available	Ring finger protein 169.	0.470
LOC101065618	LOC115247907	ENSTRUP00000053132	ENSTRUP00000010647	E3 ubiquitin-protein ligase RNF31-like isoform X1.	Si:dkey-181m9.8.	0.900
LOC101065618	optn	ENSTRUP00000053132	ENSTRUP00000026229	E3 ubiquitin-protein ligase RNF31-like isoform X1.	Optineurin.	0.651
LOC101065618	rnf31	ENSTRUP00000053132	ENSTRUP00000045452	E3 ubiquitin-protein ligase RNF31-like isoform X1.	Uncharacterized protein.	0.900
LOC101065618	tab3	ENSTRUP00000053132	ENSTRUP00000045324	E3 ubiquitin-protein ligase RNF31-like isoform X1.	TGF-beta activated kinase 1 (MAP3K7) binding protein 3.	0.457
LOC101065618	tnfaip3	ENSTRUP00000053132	ENSTRUP00000048051	E3 ubiquitin-protein ligase RNF31-like isoform X1.	Tumor necrosis factor, alpha-induced protein 3.	0.619
LOC101067616	LOC101077697	ENSTRUP00000083838	ENSTRUP00000003439	OTU deubiquitinase 7A.	Zinc finger, RAN-binding domain containing 1b.	0.406
LOC101067616	ZRANB1	ENSTRUP00000083838	ENSTRUP00000024457	OTU deubiquitinase 7A.	Zinc finger RANBP2-type containing 1.	0.406
LOC101067616	optn	ENSTRUP00000083838	ENSTRUP00000026229	OTU deubiquitinase 7A.	Optineurin.	0.404
LOC101067616	tnfaip3	ENSTRUP00000083838	ENSTRUP00000048051	OTU deubiquitinase 7A.	Tumor necrosis factor, alpha-induced protein 3.	0.428
LOC101068646	optn	ENSTRUP00000024863	ENSTRUP00000026229	E3 ubiquitin-protein ligase RNF31-like.	Optineurin.	0.651
LOC101068646	tab3	ENSTRUP00000024863	ENSTRUP00000045324	E3 ubiquitin-protein ligase RNF31-like.	TGF-beta activated kinase 1 (MAP3K7) binding protein 3.	0.457
LOC101068646	tnfaip3	ENSTRUP00000024863	ENSTRUP00000048051	E3 ubiquitin-protein ligase RNF31-like.	Tumor necrosis factor, alpha-induced protein 3.	0.619
LOC101074386	optn	ENSTRUP00000081395	ENSTRUP00000026229	Sequestosome 1.	Optineurin.	0.699
LOC101077697	LOC101067616	ENSTRUP00000003439	ENSTRUP00000083838	Zinc finger, RAN-binding domain containing 1b.	OTU deubiquitinase 7A.	0.406
LOC101077697	optn	ENSTRUP00000003439	ENSTRUP00000026229	Zinc finger, RAN-binding domain containing 1b.	Optineurin.	0.404
LOC101077697	otud7b	ENSTRUP00000003439	ENSTRUP00000033641	Zinc finger, RAN-binding domain containing 1b.	OTU deubiquitinase 7B.	0.406
LOC101077697	tnfaip3	ENSTRUP00000003439	ENSTRUP00000048051	Zinc finger, RAN-binding domain containing 1b.	Tumor necrosis factor, alpha-induced protein 3.	0.460
LOC115247907	LOC101065618	ENSTRUP00000010647	ENSTRUP00000053132	Si:dkey-181m9.8.	E3 ubiquitin-protein ligase RNF31-like isoform X1.	0.900