(47 nodes) Positive regulation of leukocyte proliferation network (Takifugu rubripes)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ptprc	Uncharacterized protein. (1248 aa)
	card11	Uncharacterized protein. (1153 aa)
	ENSTRUP00000085478	Neuromedin Bb. (134 aa)
	LOC101075512	Uncharacterized protein. (703 aa)
	vtcn1	B7-H4. (272 aa)
	LOC105417014	Ig-like domain-containing protein. (250 aa)
	LOC105416883	ZP domain-containing protein. (423 aa)
	LOC101061314	Solute carrier family 7 member 1a. (648 aa)
	zap70	Tyrosine-protein kinase. (631 aa)
	igf2	Insulin-like growth factor 2b. (215 aa)
	LOC101075059	Uncharacterized protein. (362 aa)
	cd276	Uncharacterized protein. (325 aa)
	LOC101072499	Uncharacterized protein. (982 aa)
	ENSTRUP00000070883	annotation not available (73 aa)
	LOC101074180	Deoxyhypusine synthase. (374 aa)
	LOC101067067	DED domain-containing protein. (196 aa)
	LOC101070292	AA_permease_C domain-containing protein. (681 aa)
	il34	Uncharacterized protein. (428 aa)
	ocstamp	Osteoclast stimulatory transmembrane protein. (421 aa)
	ENSTRUP00000056977	annotation not available (241 aa)
	ENSTRUP00000056963	annotation not available (197 aa)
	gpam	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (834 aa)
	LOC101076257	Colony stimulating factor 1b (macrophage). (271 aa)
	ccl19	SCY domain-containing protein. (113 aa)
	LOC101068020	CD40 ligand; Belongs to the tumor necrosis factor family. (232 aa)
	il-18	Takifugu rubripes interleukin-18 (il-18), mRNA. (185 aa)
	tnfsf13b	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (262 aa)
	mpl	MPL proto-oncogene, thrombopoietin receptor. (656 aa)
	nck1	Cytoplasmic protein. (399 aa)
	LOC101063674-2	Pleckstrin homology-like domain, family B, member 2a. (375 aa)
	LOC101062397	Allograft inflammatory factor 1. (147 aa)
	il1b	Interleukin-1; Belongs to the IL-1 family. (256 aa)
	nck2	Cytoplasmic protein. (396 aa)
	nmbr	Neuromedin B receptor; Belongs to the G-protein coupled receptor 1 family. (389 aa)
	LOC101064978	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (577 aa)
	Il-18	Interleukin-18. (185 aa)
	H2U2H7_TAKRU	Uncharacterized protein. (718 aa)
	il6st	Uncharacterized protein. (862 aa)
	sash3	SAM and SH3 domain containing 3. (377 aa)
	syk	Tyrosine-protein kinase. (619 aa)
	il12b	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (359 aa)
	cd40	CD40. (307 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (542 aa)
	tirap	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein. (180 aa)
	nfatc2	Nuclear factor of activated T cells 2a. (884 aa)
	H2SAI0_TAKRU	Receptor-interacting serine-threonine kinase 2. (554 aa)
	LOC101074837	Uncharacterized protein. (249 aa)

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSTRUP00000056963	H2SAI0_TAKRU	ENSTRUP00000056963	ENSTRUP00000009406	annotation not available	Receptor-interacting serine-threonine kinase 2.	0.641
ENSTRUP00000056963	syk	ENSTRUP00000056963	ENSTRUP00000024628	annotation not available	Tyrosine-protein kinase.	0.564
ENSTRUP00000056963	zap70	ENSTRUP00000056963	ENSTRUP00000073768	annotation not available	Tyrosine-protein kinase.	0.564
ENSTRUP00000085478	nmbr	ENSTRUP00000085478	ENSTRUP00000033813	Neuromedin Bb.	Neuromedin B receptor; Belongs to the G-protein coupled receptor 1 family.	0.820
H2SAI0_TAKRU	ENSTRUP00000056963	ENSTRUP00000009406	ENSTRUP00000056963	Receptor-interacting serine-threonine kinase 2.	annotation not available	0.641
H2SAI0_TAKRU	LOC101067067	ENSTRUP00000009406	ENSTRUP00000061734	Receptor-interacting serine-threonine kinase 2.	DED domain-containing protein.	0.641
H2SAI0_TAKRU	card11	ENSTRUP00000009406	ENSTRUP00000004660	Receptor-interacting serine-threonine kinase 2.	Uncharacterized protein.	0.567
H2SAI0_TAKRU	il1b	ENSTRUP00000009406	ENSTRUP00000040920	Receptor-interacting serine-threonine kinase 2.	Interleukin-1; Belongs to the IL-1 family.	0.433
Il-18	LOC101076257	ENSTRUP00000031535	ENSTRUP00000051327	Interleukin-18.	Colony stimulating factor 1b (macrophage).	0.437
Il-18	il12b	ENSTRUP00000031535	ENSTRUP00000022864	Interleukin-18.	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily.	0.616
Il-18	il1b	ENSTRUP00000031535	ENSTRUP00000040920	Interleukin-18.	Interleukin-1; Belongs to the IL-1 family.	0.824
LOC101062397	il1b	ENSTRUP00000041258	ENSTRUP00000040920	Allograft inflammatory factor 1.	Interleukin-1; Belongs to the IL-1 family.	0.591
LOC101062397	ptprc	ENSTRUP00000041258	ENSTRUP00000005791	Allograft inflammatory factor 1.	Uncharacterized protein.	0.470
LOC101064978	TGFBR2	ENSTRUP00000033551	ENSTRUP00000018791	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.901
LOC101067067	H2SAI0_TAKRU	ENSTRUP00000061734	ENSTRUP00000009406	DED domain-containing protein.	Receptor-interacting serine-threonine kinase 2.	0.641
LOC101067067	syk	ENSTRUP00000061734	ENSTRUP00000024628	DED domain-containing protein.	Tyrosine-protein kinase.	0.564
LOC101067067	zap70	ENSTRUP00000061734	ENSTRUP00000073768	DED domain-containing protein.	Tyrosine-protein kinase.	0.564
LOC101068020	LOC101074837	ENSTRUP00000049751	ENSTRUP00000009093	CD40 ligand; Belongs to the tumor necrosis factor family.	Uncharacterized protein.	0.524
LOC101068020	LOC101075059	ENSTRUP00000049751	ENSTRUP00000073050	CD40 ligand; Belongs to the tumor necrosis factor family.	Uncharacterized protein.	0.524
LOC101068020	cd276	ENSTRUP00000049751	ENSTRUP00000072741	CD40 ligand; Belongs to the tumor necrosis factor family.	Uncharacterized protein.	0.566