(10 nodes) JAB1/MPN/MOV34 metalloenzyme domain network (Takifugu rubripes)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	brcc3	BRCA1/BRCA2-containing complex, subunit 3. (260 aa)
	eif3h	Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (341 aa)
	mpnd	MPN domain containing. (454 aa)
	EIF3F	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (351 aa)
	arfgef1-2	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited). (346 aa)
	COPS6	COP9 signalosome subunit 6. (330 aa)
	psmd7	Proteasome 26S subunit, non-ATPase 7. (329 aa)
	psmd14	Proteasome 26S subunit, non-ATPase 14. (332 aa)
	prpf8	Pre-mRNA processing factor 8. (2338 aa)
	stambp	STAM binding protein b. (428 aa)

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COPS6	EIF3F	ENSTRUP00000065015	ENSTRUP00000084787	COP9 signalosome subunit 6.	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.543
COPS6	arfgef1-2	ENSTRUP00000065015	ENSTRUP00000070411	COP9 signalosome subunit 6.	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited).	0.998
COPS6	eif3h	ENSTRUP00000065015	ENSTRUP00000018353	COP9 signalosome subunit 6.	Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.883
COPS6	psmd14	ENSTRUP00000065015	ENSTRUP00000043942	COP9 signalosome subunit 6.	Proteasome 26S subunit, non-ATPase 14.	0.550
COPS6	psmd7	ENSTRUP00000065015	ENSTRUP00000055135	COP9 signalosome subunit 6.	Proteasome 26S subunit, non-ATPase 7.	0.471
EIF3F	COPS6	ENSTRUP00000084787	ENSTRUP00000065015	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	COP9 signalosome subunit 6.	0.543
EIF3F	arfgef1-2	ENSTRUP00000084787	ENSTRUP00000070411	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited).	0.701
EIF3F	eif3h	ENSTRUP00000084787	ENSTRUP00000018353	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.999
EIF3F	mpnd	ENSTRUP00000084787	ENSTRUP00000003964	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	MPN domain containing.	0.527
EIF3F	prpf8	ENSTRUP00000084787	ENSTRUP00000040670	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Pre-mRNA processing factor 8.	0.420
EIF3F	psmd14	ENSTRUP00000084787	ENSTRUP00000043942	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Proteasome 26S subunit, non-ATPase 14.	0.619
arfgef1-2	COPS6	ENSTRUP00000070411	ENSTRUP00000065015	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited).	COP9 signalosome subunit 6.	0.998
arfgef1-2	EIF3F	ENSTRUP00000070411	ENSTRUP00000084787	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited).	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.701
arfgef1-2	eif3h	ENSTRUP00000070411	ENSTRUP00000018353	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited).	Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.882
arfgef1-2	mpnd	ENSTRUP00000070411	ENSTRUP00000003964	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited).	MPN domain containing.	0.440
arfgef1-2	prpf8	ENSTRUP00000070411	ENSTRUP00000040670	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited).	Pre-mRNA processing factor 8.	0.447
arfgef1-2	psmd14	ENSTRUP00000070411	ENSTRUP00000043942	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited).	Proteasome 26S subunit, non-ATPase 14.	0.689
arfgef1-2	psmd7	ENSTRUP00000070411	ENSTRUP00000055135	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited).	Proteasome 26S subunit, non-ATPase 7.	0.898
brcc3	eif3h	ENSTRUP00000009042	ENSTRUP00000018353	BRCA1/BRCA2-containing complex, subunit 3.	Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.833
brcc3	psmd7	ENSTRUP00000009042	ENSTRUP00000055135	BRCA1/BRCA2-containing complex, subunit 3.	Proteasome 26S subunit, non-ATPase 7.	0.957