(32 nodes) Four-helical cytokine-like, core network (Takifugu rubripes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	scf	Uncharacterized protein. (283 aa)
	il-21	Interleukin-21. (249 aa)
	LOC101065978	Uncharacterized protein. (242 aa)
	epo	Erythropoietin; Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass; Belongs to the EPO/TPO family. (185 aa)
	ENSTRUP00000066317	Uncharacterized protein. (189 aa)
	Q2PDJ1_TAKRU	Interleukin-12 alpha. (196 aa)
	LOC105417731	Uncharacterized protein. (183 aa)
	LOC613235	Interleukin; Belongs to the IL-15/IL-21 family. (158 aa)
	Il-20	Interleukin 19 like. (175 aa)
	LOC101061955	Interleukin-12 subunit alpha; Belongs to the IL-6 superfamily. (196 aa)
	prl	Prolactin. (213 aa)
	LOC115246584	Interferon gamma. (189 aa)
	LOC105417170	Uncharacterized protein. (202 aa)
	il-6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (227 aa)
	LOC101078464	IL-6 subfamily cytokine M17. (235 aa)
	prl-2	Prolactin 2. (230 aa)
	lep	Leptin; May function as part of a signaling pathway that acts to regulate the size of the body fat depot. (152 aa)
	il15	Interleukin; Belongs to the IL-15/IL-21 family. (167 aa)
	LOC101075211	Uncharacterized protein. (195 aa)
	LOC101061166	Somatotropin; Growth hormone plays an important role in growth control and is involved in the regulation of several anabolic processes. Implicated as an osmoregulatory substance important for seawater adaptation; Belongs to the somatotropin/prolactin family. (196 aa)
	ENSTRUP00000050011	Uncharacterized protein. (232 aa)
	il12a	Interleukin-12 subunit alpha; Belongs to the IL-6 superfamily. (234 aa)
	LOC101076257	Colony stimulating factor 1b (macrophage). (271 aa)
	LOC101070289	Somatolactin alpha. (229 aa)
	LOC101068411	Uncharacterized protein. (205 aa)
	il10	Interleukin 10. (227 aa)
	ENSTRUP00000054805	Uncharacterized protein. (192 aa)
	ENSTRUP00000055465	Uncharacterized protein. (88 aa)
	LOC115246621	Interferon gamma2. (181 aa)
	ENSTRUP00000057515	Uncharacterized protein. (180 aa)
	ENSTRUP00000055710	Ciliary neurotrophic factor. (198 aa)
	LOC101064747	Uncharacterized protein. (180 aa)

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSTRUP00000054805	ENSTRUP00000057515	ENSTRUP00000054805	ENSTRUP00000057515	Uncharacterized protein.	Uncharacterized protein.	0.431
ENSTRUP00000054805	il10	ENSTRUP00000054805	ENSTRUP00000054385	Uncharacterized protein.	Interleukin 10.	0.539
ENSTRUP00000057515	ENSTRUP00000054805	ENSTRUP00000057515	ENSTRUP00000054805	Uncharacterized protein.	Uncharacterized protein.	0.431
ENSTRUP00000057515	LOC101064747	ENSTRUP00000057515	ENSTRUP00000056658	Uncharacterized protein.	Uncharacterized protein.	0.496
ENSTRUP00000066317	scf	ENSTRUP00000066317	ENSTRUP00000008264	Uncharacterized protein.	Uncharacterized protein.	0.502
Il-20	LOC105417731	ENSTRUP00000010965	ENSTRUP00000060317	Interleukin 19 like.	Uncharacterized protein.	0.566
Il-20	il10	ENSTRUP00000010965	ENSTRUP00000054385	Interleukin 19 like.	Interleukin 10.	0.453
LOC101061166	LOC101065978	ENSTRUP00000048994	ENSTRUP00000076835	Somatotropin; Growth hormone plays an important role in growth control and is involved in the regulation of several anabolic processes. Implicated as an osmoregulatory substance important for seawater adaptation; Belongs to the somatotropin/prolactin family.	Uncharacterized protein.	0.666
LOC101061166	LOC101070289	ENSTRUP00000048994	ENSTRUP00000052419	Somatotropin; Growth hormone plays an important role in growth control and is involved in the regulation of several anabolic processes. Implicated as an osmoregulatory substance important for seawater adaptation; Belongs to the somatotropin/prolactin family.	Somatolactin alpha.	0.917
LOC101061166	prl	ENSTRUP00000048994	ENSTRUP00000013528	Somatotropin; Growth hormone plays an important role in growth control and is involved in the regulation of several anabolic processes. Implicated as an osmoregulatory substance important for seawater adaptation; Belongs to the somatotropin/prolactin family.	Prolactin.	0.717
LOC101061166	prl-2	ENSTRUP00000048994	ENSTRUP00000031786	Somatotropin; Growth hormone plays an important role in growth control and is involved in the regulation of several anabolic processes. Implicated as an osmoregulatory substance important for seawater adaptation; Belongs to the somatotropin/prolactin family.	Prolactin 2.	0.697
LOC101064747	ENSTRUP00000057515	ENSTRUP00000056658	ENSTRUP00000057515	Uncharacterized protein.	Uncharacterized protein.	0.496
LOC101065978	LOC101061166	ENSTRUP00000076835	ENSTRUP00000048994	Uncharacterized protein.	Somatotropin; Growth hormone plays an important role in growth control and is involved in the regulation of several anabolic processes. Implicated as an osmoregulatory substance important for seawater adaptation; Belongs to the somatotropin/prolactin family.	0.666
LOC101065978	LOC101070289	ENSTRUP00000076835	ENSTRUP00000052419	Uncharacterized protein.	Somatolactin alpha.	0.666
LOC101065978	lep	ENSTRUP00000076835	ENSTRUP00000034085	Uncharacterized protein.	Leptin; May function as part of a signaling pathway that acts to regulate the size of the body fat depot.	0.493
LOC101065978	prl	ENSTRUP00000076835	ENSTRUP00000013528	Uncharacterized protein.	Prolactin.	0.902
LOC101065978	prl-2	ENSTRUP00000076835	ENSTRUP00000031786	Uncharacterized protein.	Prolactin 2.	0.904
LOC101068411	scf	ENSTRUP00000054315	ENSTRUP00000008264	Uncharacterized protein.	Uncharacterized protein.	0.901
LOC101070289	LOC101061166	ENSTRUP00000052419	ENSTRUP00000048994	Somatolactin alpha.	Somatotropin; Growth hormone plays an important role in growth control and is involved in the regulation of several anabolic processes. Implicated as an osmoregulatory substance important for seawater adaptation; Belongs to the somatotropin/prolactin family.	0.917
LOC101070289	LOC101065978	ENSTRUP00000052419	ENSTRUP00000076835	Somatolactin alpha.	Uncharacterized protein.	0.666