STRINGSTRING
LOC101063644 LOC101063644 nab1 nab1 LOC101078202 LOC101078202 egr2 egr2 ap2a2 ap2a2 egr3 egr3 fyn fyn fnbp4 fnbp4 crkl crkl PIK3CA PIK3CA LOC101061679 LOC101061679 dusp3 dusp3 LOC101068137 LOC101068137 JUND JUND LOC101069496 LOC101069496 LOC101067191 LOC101067191 LOC101069736 LOC101069736 LOC101079195 LOC101079195 LOC101066950 LOC101066950 junb junb pik3cb pik3cb LOC101073597 LOC101073597 LOC101077771 LOC101077771 ppp2ca ppp2ca mapk15 mapk15 shc2 shc2 MAPKAPK3 MAPKAPK3 LOC101076043 LOC101076043 SHC3 SHC3 LOC101071645 LOC101071645 H2TTY9_TAKRU H2TTY9_TAKRU ppp2cb ppp2cb LOC101066372 LOC101066372 Fash1 Fash1 LOC101065989 LOC101065989 ascl1 ascl1 ntrk1 ntrk1 rala rala LOC101067377 LOC101067377 nkpd1 nkpd1 H2V4V2_TAKRU H2V4V2_TAKRU srf srf H2V9Z6_TAKRU H2V9Z6_TAKRU LOC101076370 LOC101076370 rapgef1 rapgef1 src src ppp4r1 ppp4r1 ENSTRUP00000048455 ENSTRUP00000048455 LOC101065425 LOC101065425 LOC101073920 LOC101073920 mapk1 mapk1 hras hras LOC101076843 LOC101076843 mapk7 mapk7 bax bax kras kras LOC101072454 LOC101072454 ntf3 ntf3 dusp6 dusp6 fosl1 fosl1 mapkapk2 mapkapk2 LOC101076471 LOC101076471 id3 id3 trib2 trib2 fndc3a fndc3a LOC101066563 LOC101066563 plcg1 plcg1 ntrk3 ntrk3 vrk3 vrk3 LOC101078322 LOC101078322 LOC101066672 LOC101066672 LOC115253205 LOC115253205 nab2 nab2 dnal4 dnal4 ENSTRUP00000063292 ENSTRUP00000063292 H2RJH3_TAKRU H2RJH3_TAKRU LOC101063191 LOC101063191 egr1 egr1 LOC101070329 LOC101070329 map2k5 map2k5 map2k2 map2k2 ap2m1 ap2m1 H2TI00_TAKRU H2TI00_TAKRU pcsk5 pcsk5 LOC101070100 LOC101070100 SGK1 SGK1 LOC101078142 LOC101078142 kidins220 kidins220 LOC101062654 LOC101062654 dusp7 dusp7 ap2s1 ap2s1 ppp2r1b ppp2r1b ENSTRUP00000073880 ENSTRUP00000073880 LOC101061571 LOC101061571 relch relch ENSTRUP00000078829 ENSTRUP00000078829 LOC101064045 LOC101064045 CSDE1 CSDE1 LOC101069363 LOC101069363 map2k1 map2k1 id2 id2 LOC115251795 LOC115251795 LOC101065692 LOC101065692 LOC101074428 LOC101074428 LOC101065281 LOC101065281 clta clta fndc3b fndc3b frs2 frs2 atf1 atf1 LOC101073756 LOC101073756 ENSTRUP00000087641 ENSTRUP00000087641
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC101063644Inhibitor of DNA binding 4. (138 aa)
nab1NGFI-A binding protein 1a (EGR1 binding protein 1). (556 aa)
LOC101078202Tyrosine-protein kinase receptor. (581 aa)
egr2Early growth response 2b. (430 aa)
ap2a2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (955 aa)
egr3Early growth response 3. (412 aa)
fynTyrosine-protein kinase. (538 aa)
fnbp4Formin binding protein 4. (888 aa)
crklV-crk avian sarcoma virus CT10 oncogene homolog-like. (299 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC101061679cAMP responsive element modulator b. (111 aa)
dusp3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (267 aa)
LOC101068137Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (228 aa)
JUNDBZIP domain-containing protein. (282 aa)
LOC101069496Insulin receptor substrate 2b. (1096 aa)
LOC101067191Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC101069736Zgc:55558. (187 aa)
LOC101079195V-ral simian leukemia viral oncogene homolog Ba (ras related). (233 aa)
LOC101066950AP complex subunit beta. (966 aa)
junbJunB protein. (331 aa)
pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1098 aa)
LOC101073597Uncharacterized protein. (1977 aa)
LOC101077771Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (370 aa)
ppp2caSerine/threonine-protein phosphatase. (309 aa)
mapk15Mitogen-activated protein kinase. (598 aa)
shc2SHC (Src homology 2 domain containing) transforming protein 2. (718 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (404 aa)
LOC101076043Insulin receptor substrate 2a. (1054 aa)
SHC3SHC adaptor protein 3. (660 aa)
LOC101071645Ribosomal protein S6 kinase. (750 aa)
H2TTY9_TAKRUNerve growth factor a (beta polypeptide); Belongs to the NGF-beta family. (205 aa)
ppp2cbSerine/threonine-protein phosphatase. (309 aa)
LOC101066372MADS-box domain-containing protein. (514 aa)
Fash1Achaete-scute family bHLH transcription factor 1b. (194 aa)
LOC101065989CRK proto-oncogene, adaptor protein. (319 aa)
ascl1Achaete-scute family bHLH transcription factor 1a. (201 aa)
ntrk1Tyrosine-protein kinase receptor. (624 aa)
ralaV-ral simian leukemia viral oncogene homolog Aa (ras related). (202 aa)
LOC101067377Mitogen-activated protein kinase. (408 aa)
nkpd1NTPase, KAP family P-loop domain containing 1. (736 aa)
H2V4V2_TAKRUBrain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (244 aa)
srfSerum response factor b. (541 aa)
H2V9Z6_TAKRUP/Homo B domain-containing protein. (891 aa)
LOC101076370Nerve growth factor b (beta polypeptide); Belongs to the NGF-beta family. (190 aa)
rapgef1Rap guanine nucleotide exchange factor (GEF) 1b. (1194 aa)
srcTyrosine-protein kinase. (552 aa)
ppp4r1WRNPLPNID domain-containing protein. (967 aa)
ENSTRUP00000048455BZIP domain-containing protein. (123 aa)
LOC101065425Uncharacterized protein. (201 aa)
LOC101073920BHLH domain-containing protein. (388 aa)
mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (390 aa)
hrasHRas proto-oncogene, GTPase a. (189 aa)
LOC101076843JunD proto-oncogene, AP-1 transcription factor subunit. (313 aa)
mapk7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (1147 aa)
baxBCL2 associated X, apoptosis regulator a. (193 aa)
krasV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (210 aa)
LOC101072454ETS transcription factor ELK1. (563 aa)
ntf3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (290 aa)
dusp6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (383 aa)
fosl1FOS-like antigen 1a. (338 aa)
mapkapk2MAPK activated protein kinase 2a; Belongs to the protein kinase superfamily. (383 aa)
LOC101076471Uncharacterized protein. (363 aa)
id3Inhibitor of DNA binding 3. (118 aa)
trib2Tribbles pseudokinase 2. (345 aa)
fndc3aFibronectin type III domain containing 3A. (1253 aa)
LOC101066563Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (391 aa)
plcg11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1314 aa)
ntrk3Neurotrophic tyrosine kinase, receptor, type 3b; Belongs to the protein kinase superfamily. Tyr protein kinase family. (848 aa)
vrk3VRK serine/threonine kinase 3. (634 aa)
LOC101078322Furin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family. (828 aa)
LOC101066672MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (401 aa)
LOC115253205PiggyBac transposable element-derived protein 4-like. (411 aa)
nab2NGFI-A binding protein 2 (EGR1 binding protein 2). (477 aa)
dnal4Dynein light chain. (106 aa)
ENSTRUP00000063292BDNF/NT-3 growth factors receptor-like isoform X1. (249 aa)
H2RJH3_TAKRUCHDCT2 domain-containing protein. (1937 aa)
LOC101063191Tyrosine-protein kinase fyna. (554 aa)
egr1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (580 aa)
LOC101070329Uncharacterized protein. (351 aa)
map2k5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (432 aa)
map2k2Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (399 aa)
ap2m1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (441 aa)
H2TI00_TAKRUTyrosine-protein kinase receptor. (838 aa)
pcsk5Proprotein convertase subtilisin/kexin type 5b; Belongs to the peptidase S8 family. (1833 aa)
LOC101070100Kinase D-interacting substrate 220b. (1727 aa)
SGK1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (623 aa)
LOC101078142Ribosomal protein S6 kinase. (811 aa)
kidins220ANK_REP_REGION domain-containing protein. (1693 aa)
LOC101062654AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (963 aa)
dusp7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (384 aa)
ap2s1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (145 aa)
ppp2r1bProtein phosphatase 2, regulatory subunit A, beta b. (619 aa)
ENSTRUP00000073880annotation not available (402 aa)
LOC101061571Furin (paired basic amino acid cleaving enzyme) b; Belongs to the peptidase S8 family. (835 aa)
relchRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1195 aa)
ENSTRUP00000078829Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (967 aa)
LOC101064045Mitogen-activated protein kinase. (383 aa)
CSDE1Cold shock domain containing E1, RNA-binding. (905 aa)
LOC101069363Neurotrophin 4; Belongs to the NGF-beta family. (423 aa)
map2k1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
id2Inhibitor of DNA binding 2a. (169 aa)
LOC115251795Tribbles pseudokinase 1. (355 aa)
LOC101065692SH3 domain containing GRB2 like 2a, endophilin A1. (363 aa)
LOC101074428Mitogen-activated protein kinase. (412 aa)
LOC101065281Tyrosine-protein kinase. (552 aa)
cltaClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (232 aa)
fndc3bFibronectin type III domain containing 3Ba. (1224 aa)
frs2Fibroblast growth factor receptor substrate 2b. (1049 aa)
atf1Activating transcription factor 1. (311 aa)
LOC101073756Ribosomal protein S6 kinase. (800 aa)
ENSTRUP00000087641Neurotrophin-4-like. (213 aa)
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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