STRINGSTRING
pik3cb pik3cb ENSTRUP00000088182 ENSTRUP00000088182 frs2 frs2 shc4 shc4 ENSTRUP00000084403 ENSTRUP00000084403 H2S3Y8_TAKRU H2S3Y8_TAKRU LOC101063860 LOC101063860 LCT LCT ENSTRUP00000078829 ENSTRUP00000078829 LOC101069995 LOC101069995 pde3b pde3b fgf3 fgf3 igf2 igf2 FGF13 FGF13 LOC101071373 LOC101071373 LOC101063427 LOC101063427 igf1 igf1 LOC101077596-2 LOC101077596-2 LOC101078100 LOC101078100 fgf8 fgf8 fgf7 fgf7 LOC101072794 LOC101072794 LOC101068538 LOC101068538 shc1 shc1 LOC101069856 LOC101069856 fgf16 fgf16 LOC101065833 LOC101065833 ENSTRUP00000052849 ENSTRUP00000052849 LOC101069368 LOC101069368 fgf22 fgf22 LOC101070196 LOC101070196 LOC101074788 LOC101074788 LOC101061204 LOC101061204 LOC101067042 LOC101067042 LOC101073964 LOC101073964 fgfr2 fgfr2 fgf17 fgf17 LOC101078435 LOC101078435 fgf10 fgf10 fgfr1 fgfr1 pdpk1 pdpk1 LOC101079603 LOC101079603 LOC101070231 LOC101070231 LOC101073070 LOC101073070 gab1 gab1 gab2 gab2 FGF6-2 FGF6-2 LOC101061209 LOC101061209 LOC101065438 LOC101065438 FGF6 FGF6 klb klb LOC101076043 LOC101076043 ENSTRUP00000023848 ENSTRUP00000023848 AKT2 AKT2 grb2 grb2 LOC101067191 LOC101067191 LOC101069496 LOC101069496 LOC101079556 LOC101079556 PIK3CA PIK3CA LOC101064999 LOC101064999 LOC101064761 LOC101064761 ENSTRUP00000004692 ENSTRUP00000004692 LOC101067940 LOC101067940 fgf5 fgf5 LOC101077596 LOC101077596
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1098 aa)
ENSTRUP00000088182annotation not available (138 aa)
frs2Fibroblast growth factor receptor substrate 2b. (1049 aa)
shc4SHC-transforming protein 4 isoform X2. (470 aa)
ENSTRUP00000084403Fibroblast growth factor 23-like. (141 aa)
H2S3Y8_TAKRUFibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
LOC101063860Fibroblast growth factor receptor 3. (842 aa)
LCTUncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (1924 aa)
ENSTRUP00000078829Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (967 aa)
LOC101069995Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (154 aa)
pde3bPhosphodiesterase. (1108 aa)
fgf3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (238 aa)
igf2Insulin-like growth factor 2b. (215 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (284 aa)
LOC101071373Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
LOC101063427Tyrosine-protein kinase receptor. (1426 aa)
igf1IlGF domain-containing protein. (188 aa)
LOC101077596-2Klotho-like. (976 aa)
LOC101078100Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (302 aa)
fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
fgf7Fibroblast growth factor 7; Belongs to the heparin-binding growth factors family. (238 aa)
LOC101072794Si:ch211-284e13.4. (1133 aa)
LOC101068538Fibroblast growth factor receptor 4. (1053 aa)
shc1SHC (Src homology 2 domain containing) transforming protein 1. (594 aa)
LOC101069856Tribbles pseudokinase 3. (349 aa)
fgf16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
LOC101065833Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (226 aa)
ENSTRUP00000052849Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (148 aa)
LOC101069368Si:ch73-335l21.1. (1274 aa)
fgf22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
LOC101070196Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
LOC101074788Insulin receptor substrate 4a. (1378 aa)
LOC101061204Uncharacterized protein. (205 aa)
LOC101067042Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
LOC101073964Fibroblast growth factor receptor. (729 aa)
fgfr2Fibroblast growth factor receptor. (838 aa)
fgf17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (278 aa)
LOC101078435PH domain-containing protein. (744 aa)
fgf10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
fgfr1Fibroblast growth factor receptor. (845 aa)
pdpk13-phosphoinositide dependent protein kinase 1b. (559 aa)
LOC101079603Tyrosine-protein kinase receptor. (1416 aa)
LOC101070231Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
LOC101073070Lactase-like b; Belongs to the glycosyl hydrolase 1 family. (539 aa)
gab1GRB2-associated binding protein 1. (749 aa)
gab2GRB2-associated binding protein 2. (679 aa)
FGF6-2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa)
LOC101061209Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (263 aa)
LOC101065438Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
klbKlotho beta. (1046 aa)
LOC101076043Insulin receptor substrate 2a. (1054 aa)
ENSTRUP00000023848Lactase-like protein isoform X2. (291 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
grb2Growth factor receptor-bound protein 2b. (220 aa)
LOC101067191Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC101069496Insulin receptor substrate 2b. (1096 aa)
LOC101079556Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (179 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC101064999Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
LOC101064761Thioesterase superfamily member 4. (253 aa)
ENSTRUP00000004692LOW QUALITY PROTEIN: lactase-phlorizin hydrolase-like. (606 aa)
LOC101067940Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
fgf5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (229 aa)
LOC101077596Klotho; Belongs to the glycosyl hydrolase 1 family. (976 aa)
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.