STRINGSTRING
LOC101077362 LOC101077362 mmp9 mmp9 LOC101069728 LOC101069728 rasa1 rasa1 cltb cltb LOC101077303 LOC101077303 fyn fyn pak1 pak1 LOC101069940 LOC101069940 LOC101072622 LOC101072622 LOC101066950 LOC101066950 ephb3 ephb3 VAV3 VAV3 cltc cltc cfl2 cfl2 H2T5C2_TAKRU H2T5C2_TAKRU LOC101063506 LOC101063506 EFNA2 EFNA2 LOC101077114 LOC101077114 LOC101079431 LOC101079431 LOC101073085 LOC101073085 LOC101076765 LOC101076765 cfl1 cfl1 LOC101062581 LOC101062581 LOC101067733 LOC101067733 rock1 rock1 grin1 grin1 ENSTRUP00000034556 ENSTRUP00000034556 PAK2 PAK2 arpc2 arpc2 LOC101064301 LOC101064301 LOC101069150 LOC101069150 EFNA5 EFNA5 LOC101071646 LOC101071646 wasl wasl LOC101069458 LOC101069458 PAK3 PAK3 LOC101078775 LOC101078775 src src dnm1 dnm1 LOC101077341 LOC101077341 hras hras efna1 efna1 psen2 psen2 ENSTRUP00000052717 ENSTRUP00000052717 dstn dstn ephb4 ephb4 ACTR3 ACTR3 LOC101072391 LOC101072391 fndc3a fndc3a LOC101080137 LOC101080137 LOC101072072 LOC101072072 epha3 epha3 LOC101069639 LOC101069639 GRIN2B GRIN2B arpc5 arpc5 epha10 epha10 LOC101074914 LOC101074914 LOC101067410 LOC101067410 pak2 pak2 LOC101063191 LOC101063191 efnb1 efnb1 H2RIU2_TAKRU H2RIU2_TAKRU rock2 rock2 LOC101071667 LOC101071667 VAV1 VAV1 LOC101063508 LOC101063508 EPHA6 EPHA6 actr2 actr2 ap2m1 ap2m1 ENSTRUP00000068902 ENSTRUP00000068902 LOC101066462 LOC101066462 YES1 YES1 vav2 vav2 LOC101068187 LOC101068187 itsn1 itsn1 LOC101062654 LOC101062654 ap2s1 ap2s1 H2TD77_TAKRU H2TD77_TAKRU LOC105418655 LOC105418655 LOC101066900 LOC101066900 psenen psenen ENSTRUP00000076191 ENSTRUP00000076191 LOC101071929 LOC101071929 H2TKL1_TAKRU H2TKL1_TAKRU LOC101073733 LOC101073733 LOC101071166 LOC101071166 LOC101067723 LOC101067723 LOC101070937 LOC101070937 mmp2 mmp2 LOC101064109 LOC101064109 LOC101072336 LOC101072336 LOC101069656 LOC101069656 LOC101078156 LOC101078156 LOC101068145 LOC101068145 LOC101065603 LOC101065603 LOC101072452 LOC101072452 arpc3 arpc3 epha4 epha4 LOC101074460 LOC101074460 LOC101074532 LOC101074532 LOC101065281 LOC101065281 ngef ngef ENSTRUP00000085673 ENSTRUP00000085673 clta clta fndc3b fndc3b LOC101069102 LOC101069102 FMN1 FMN1 LOC101079033 LOC101079033 arpc1a arpc1a LOC101076719 LOC101076719 NCSTN NCSTN LOC101079238 LOC101079238
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC101077362Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1662 aa)
mmp9Uncharacterized protein. (631 aa)
LOC101069728Eph receptor A2 b. (987 aa)
rasa1RAS p21 protein activator (GTPase activating protein) 1a. (1056 aa)
cltbClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (245 aa)
LOC101077303Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (470 aa)
fynTyrosine-protein kinase. (538 aa)
pak1Non-specific serine/threonine protein kinase. (562 aa)
LOC101069940Eph receptor B2a. (1009 aa)
LOC101072622Ephrin-A3b; Belongs to the ephrin family. (220 aa)
LOC101066950AP complex subunit beta. (966 aa)
ephb3Uncharacterized protein. (1013 aa)
VAV3Si:ch73-383g2.1. (830 aa)
cltcClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1678 aa)
cfl2Cofilin 2 (muscle); Belongs to the actin-binding proteins ADF family. (167 aa)
H2T5C2_TAKRUUncharacterized protein. (351 aa)
LOC101063506Receptor protein-tyrosine kinase. (1004 aa)
EFNA2Ephrin A2; Belongs to the ephrin family. (219 aa)
LOC101077114Ephrin-A3-like. (224 aa)
LOC101079431Zgc:86896. (356 aa)
LOC101073085Eph receptor A2 a. (974 aa)
LOC101076765Vav 3 guanine nucleotide exchange factor b. (829 aa)
cfl1Cofilin 1; Belongs to the actin-binding proteins ADF family. (167 aa)
LOC101062581Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (154 aa)
LOC101067733EPH receptor B1. (1013 aa)
rock1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1365 aa)
grin1Uncharacterized protein. (1009 aa)
ENSTRUP00000034556Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed. (429 aa)
PAK2Non-specific serine/threonine protein kinase. (547 aa)
arpc2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (299 aa)
LOC101064301Rho guanine nucleotide exchange factor (GEF) 7a. (863 aa)
LOC101069150APH1B gamma secretase subunit. (258 aa)
EFNA5Ephrin-A5b; Belongs to the ephrin family. (229 aa)
LOC101071646Uncharacterized protein. (545 aa)
waslWASP like actin nucleation promoting factor a. (527 aa)
LOC101069458WASP like actin nucleation promoting factor b. (505 aa)
PAK3Non-specific serine/threonine protein kinase. (575 aa)
LOC101078775Ephrin RBD domain-containing protein; Belongs to the ephrin family. (323 aa)
srcTyrosine-protein kinase. (552 aa)
dnm1Dynamin 1a; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (858 aa)
LOC101077341Ephrin-A1a; Belongs to the ephrin family. (227 aa)
hrasHRas proto-oncogene, GTPase a. (189 aa)
efna1Ephrin-A1b; Belongs to the ephrin family. (234 aa)
psen2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (418 aa)
ENSTRUP00000052717Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed. (413 aa)
dstnADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (196 aa)
ephb4Eph receptor B4a. (985 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (433 aa)
LOC101072391Si:dkey-246i14.3; Belongs to the ephrin family. (201 aa)
fndc3aFibronectin type III domain containing 3A. (1253 aa)
LOC101080137Eph LBD domain-containing protein. (988 aa)
LOC101072072Si:ch211-1o7.3. (553 aa)
epha3Eph receptor A3. (994 aa)
LOC101069639Tyrosine-protein kinase. (537 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1702 aa)
arpc5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (150 aa)
epha10Eph LBD domain-containing protein. (1063 aa)
LOC101074914Actin-related protein 3; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged [...] (436 aa)
LOC101067410Eph receptor B3a. (926 aa)
pak2Non-specific serine/threonine protein kinase. (528 aa)
LOC101063191Tyrosine-protein kinase fyna. (554 aa)
efnb1Ephrin-B1; Belongs to the ephrin family. (332 aa)
H2RIU2_TAKRUUncharacterized protein. (278 aa)
rock2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1398 aa)
LOC101071667Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1677 aa)
VAV1Vav guanine nucleotide exchange factor 1. (835 aa)
LOC101063508Ephrin-B3a; Belongs to the ephrin family. (342 aa)
EPHA6EPH receptor A6. (1012 aa)
actr2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (410 aa)
ap2m1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (441 aa)
ENSTRUP00000068902annotation not available (1081 aa)
LOC101066462Rho guanine nucleotide exchange factor (GEF) 7b. (851 aa)
YES1Tyrosine-protein kinase. (549 aa)
vav2Vav 2 guanine nucleotide exchange factor. (881 aa)
LOC101068187Eph LBD domain-containing protein. (1026 aa)
itsn1Intersectin 1 (SH3 domain protein). (1800 aa)
LOC101062654AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (963 aa)
ap2s1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (145 aa)
H2TD77_TAKRUFH2 domain-containing protein. (1296 aa)
LOC105418655Fibronectin type-III domain-containing protein. (589 aa)
LOC101066900Actin related protein 2/3 complex subunit 4. (216 aa)
psenenPresenilin enhancer, gamma-secretase subunit. (101 aa)
ENSTRUP00000076191Formin 1. (1021 aa)
LOC101071929Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1053 aa)
H2TKL1_TAKRUActin related protein 2/3 complex, subunit 4. (185 aa)
LOC101073733Uncharacterized protein. (202 aa)
LOC101071166Uncharacterized protein. (1088 aa)
LOC101067723Cell division cycle 42. (191 aa)
LOC101070937Eph receptor A4b. (983 aa)
mmp2Matrix metalloproteinase-2. (663 aa)
LOC101064109Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (210 aa)
LOC101072336T cell lymphoma invasion and metastasis 1b. (1513 aa)
LOC101069656Ephrin-A2a; Belongs to the ephrin family. (206 aa)
LOC101078156Uncharacterized protein. (928 aa)
LOC101068145Uncharacterized protein. (191 aa)
LOC101065603Eph receptor B2b. (1000 aa)
LOC101072452Syndecan binding protein (syntenin) 2. (302 aa)
arpc3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (236 aa)
epha4Eph receptor A4, like. (991 aa)
LOC101074460Ephrin type-B receptor 4-like. (1015 aa)
LOC101074532Glutamate receptor, ionotropic, N-methyl D-aspartate 1a. (970 aa)
LOC101065281Tyrosine-protein kinase. (552 aa)
ngefNeuronal guanine nucleotide exchange factor. (766 aa)
ENSTRUP00000085673Eph receptor A7. (1008 aa)
cltaClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (232 aa)
fndc3bFibronectin type III domain containing 3Ba. (1224 aa)
LOC101069102Actin, cytoplasmic 3, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (399 aa)
FMN1Formin 1. (1256 aa)
LOC101079033Zgc:101810; Belongs to the actin family. (395 aa)
arpc1aActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (401 aa)
LOC101076719Ephrin-A5a; Belongs to the ephrin family. (226 aa)
NCSTNNicastrin. (711 aa)
LOC101079238T cell lymphoma invasion and metastasis 1a. (1674 aa)
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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