39 items (Takifugu rubripes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	shc4	SHC-transforming protein 4 isoform X2. (470 aa)
	frs2	Fibroblast growth factor receptor substrate 2b. (1049 aa)
	ENSTRUP00000088182	annotation not available (138 aa)
	fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	fgf5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (229 aa)
	LOC101067940	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
	LOC101064999	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC101079556	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (179 aa)
	LOC101067191	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC101069736	Zgc:55558. (187 aa)
	grb2	Growth factor receptor-bound protein 2b. (220 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	LOC101061209	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (263 aa)
	FGF6-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa)
	gab1	GRB2-associated binding protein 1. (749 aa)
	LOC101074964	Fibroblast growth factor receptor substrate 3. (613 aa)
	LOC101070231	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
	fgf10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
	LOC101078435	PH domain-containing protein. (744 aa)
	fgf17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (278 aa)
	fgfr2	Fibroblast growth factor receptor. (838 aa)
	LOC101067042	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	LOC101061204	Uncharacterized protein. (205 aa)
	LOC101070196	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
	fgf22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	kras	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (210 aa)
	ENSTRUP00000052849	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (148 aa)
	shc1	SHC (Src homology 2 domain containing) transforming protein 1. (594 aa)
	fgf7	Fibroblast growth factor 7; Belongs to the heparin-binding growth factors family. (238 aa)
	plcg1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1314 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	LOC115253205	PiggyBac transposable element-derived protein 4-like. (411 aa)
	LOC101071373	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (238 aa)
	LOC101069995	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (154 aa)
	ENSTRUP00000078829	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (967 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (905 aa)

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	ENSTRUP00000052849	ENSTRUP00000080673	ENSTRUP00000052849	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.427
CSDE1	ENSTRUP00000078829	ENSTRUP00000080673	ENSTRUP00000078829	Cold shock domain containing E1, RNA-binding.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.509
CSDE1	LOC101061204	ENSTRUP00000080673	ENSTRUP00000049272	Cold shock domain containing E1, RNA-binding.	Uncharacterized protein.	0.593
CSDE1	LOC101061209	ENSTRUP00000080673	ENSTRUP00000027922	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.435
CSDE1	LOC101067042	ENSTRUP00000080673	ENSTRUP00000049123	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.455
CSDE1	LOC101067191	ENSTRUP00000080673	ENSTRUP00000016050	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.509
CSDE1	LOC101067940	ENSTRUP00000080673	ENSTRUP00000003093	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	0.455
CSDE1	LOC101069995	ENSTRUP00000080673	ENSTRUP00000078224	Cold shock domain containing E1, RNA-binding.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.444
CSDE1	LOC101074964	ENSTRUP00000080673	ENSTRUP00000038716	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor receptor substrate 3.	0.443
CSDE1	LOC101079556	ENSTRUP00000080673	ENSTRUP00000012796	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.427
CSDE1	PIK3CA	ENSTRUP00000080673	ENSTRUP00000009530	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.509
CSDE1	fgf17	ENSTRUP00000080673	ENSTRUP00000044857	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.446
CSDE1	fgf3	ENSTRUP00000080673	ENSTRUP00000074114	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.466
CSDE1	fgf5	ENSTRUP00000080673	ENSTRUP00000002293	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.437
CSDE1	fgf7	ENSTRUP00000080673	ENSTRUP00000056954	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor 7; Belongs to the heparin-binding growth factors family.	0.453
CSDE1	fgf8	ENSTRUP00000080673	ENSTRUP00000058477	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.453
CSDE1	frs2	ENSTRUP00000080673	ENSTRUP00000086584	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor receptor substrate 2b.	0.443
CSDE1	grb2	ENSTRUP00000080673	ENSTRUP00000020659	Cold shock domain containing E1, RNA-binding.	Growth factor receptor-bound protein 2b.	0.593
CSDE1	shc1	ENSTRUP00000080673	ENSTRUP00000055854	Cold shock domain containing E1, RNA-binding.	SHC (Src homology 2 domain containing) transforming protein 1.	0.431
CSDE1	shc4	ENSTRUP00000080673	ENSTRUP00000086042	Cold shock domain containing E1, RNA-binding.	SHC-transforming protein 4 isoform X2.	0.431