68 items (Takifugu rubripes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101067042	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	LOC101061204	Uncharacterized protein. (205 aa)
	LOC101070196	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
	mapk1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (390 aa)
	fgf22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	kras	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (210 aa)
	ENSTRUP00000052849	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (148 aa)
	shc1	SHC (Src homology 2 domain containing) transforming protein 1. (594 aa)
	fndc3a	Fibronectin type III domain containing 3A. (1253 aa)
	LOC101066563	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (391 aa)
	plcg1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1314 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	LOC445932	Anosmin 1b. (715 aa)
	LOC101067205	WAP domain-containing protein. (649 aa)
	LOC115253205	PiggyBac transposable element-derived protein 4-like. (411 aa)
	cbl	Cbl proto-oncogene, E3 ubiquitin protein ligase. (951 aa)
	ENSTRUP00000064799	annotation not available (598 aa)
	FGFRL1	Fibroblast growth factor receptor like 1. (521 aa)
	LOC101071062	Sprouty related EVH1 domain containing 2a. (427 aa)
	LOC115252788	Fibronectin leucine rich transmembrane protein 1. (681 aa)
	fgf5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (229 aa)
	LOC101067940	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
	LOC101064999	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	LOC101079556	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (179 aa)
	LOC101069386	Fibronectin leucine rich transmembrane protein 2. (654 aa)
	LOC101067191	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC101069736	Zgc:55558. (187 aa)
	ppp2ca	Serine/threonine-protein phosphatase. (309 aa)
	grb2	Growth factor receptor-bound protein 2b. (220 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	LOC101061209	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (263 aa)
	FGF6-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa)
	ppp2cb	Serine/threonine-protein phosphatase. (309 aa)
	LOC101070370	Uncharacterized protein. (862 aa)
	LOC115252438	Fibronectin leucine rich transmembrane protein 1b. (732 aa)
	gab1	GRB2-associated binding protein 1. (749 aa)
	LOC101074964	Fibroblast growth factor receptor substrate 3. (613 aa)
	LOC101071373	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	ENSTRUP00000088182	annotation not available (138 aa)
	SPRED2	Sprouty related EVH1 domain containing 2. (503 aa)
	H2SX87_TAKRU	Sprouty RTK signaling antagonist 2. (370 aa)
	ENSTRUP00000087098	annotation not available (189 aa)
	frs2	Fibroblast growth factor receptor substrate 2b. (1049 aa)
	fndc3b	Fibronectin type III domain containing 3Ba. (1224 aa)
	shc4	SHC-transforming protein 4 isoform X2. (470 aa)
	ANOS1	Anosmin 1. (721 aa)
	LOC101065281	Tyrosine-protein kinase. (552 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (905 aa)
	ENSTRUP00000078829	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (967 aa)
	LOC101069995	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (154 aa)
	spred1	Sprouty-related, EVH1 domain-containing protein 1. (456 aa)
	mknk1	MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (489 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (238 aa)
	ppp2r1b	Protein phosphatase 2, regulatory subunit A, beta b. (619 aa)
	ENSTRUP00000070707	annotation not available (656 aa)
	mknk2	MAPK interacting serine/threonine kinase 2b; Belongs to the protein kinase superfamily. (474 aa)
	fgfrl1	Fibroblast growth factor receptor like 1a. (495 aa)
	LOC101070231	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
	fgfr1	Fibroblast growth factor receptor. (845 aa)
	fgf10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
	LOC101078435	PH domain-containing protein. (744 aa)
	fgf17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (278 aa)
	flrt3	Fibronectin leucine rich transmembrane 3. (650 aa)
	src	Tyrosine-protein kinase. (552 aa)

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANOS1	ENSTRUP00000052849	ENSTRUP00000084678	ENSTRUP00000052849	Anosmin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.424
ANOS1	FGFRL1	ENSTRUP00000084678	ENSTRUP00000067976	Anosmin 1.	Fibroblast growth factor receptor like 1.	0.524
ANOS1	LOC101061209	ENSTRUP00000084678	ENSTRUP00000027922	Anosmin 1.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.491
ANOS1	LOC101064999	ENSTRUP00000084678	ENSTRUP00000008737	Anosmin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.459
ANOS1	LOC101069995	ENSTRUP00000084678	ENSTRUP00000078224	Anosmin 1.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.459
ANOS1	LOC101070231	ENSTRUP00000084678	ENSTRUP00000039249	Anosmin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.459
ANOS1	LOC101071373	ENSTRUP00000084678	ENSTRUP00000068288	Anosmin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.427
ANOS1	LOC101079556	ENSTRUP00000084678	ENSTRUP00000012796	Anosmin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.424
ANOS1	fgf17	ENSTRUP00000084678	ENSTRUP00000044857	Anosmin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.630
ANOS1	fgf5	ENSTRUP00000084678	ENSTRUP00000002293	Anosmin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.412
ANOS1	fgf8	ENSTRUP00000084678	ENSTRUP00000058477	Anosmin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.693
ANOS1	fgfr1	ENSTRUP00000084678	ENSTRUP00000042243	Anosmin 1.	Fibroblast growth factor receptor.	0.700
ANOS1	fgfrl1	ENSTRUP00000084678	ENSTRUP00000038805	Anosmin 1.	Fibroblast growth factor receptor like 1a.	0.524
CSDE1	ENSTRUP00000052849	ENSTRUP00000080673	ENSTRUP00000052849	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.427
CSDE1	ENSTRUP00000078829	ENSTRUP00000080673	ENSTRUP00000078829	Cold shock domain containing E1, RNA-binding.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.509
CSDE1	LOC101061204	ENSTRUP00000080673	ENSTRUP00000049272	Cold shock domain containing E1, RNA-binding.	Uncharacterized protein.	0.593
CSDE1	LOC101061209	ENSTRUP00000080673	ENSTRUP00000027922	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.435
CSDE1	LOC101066563	ENSTRUP00000080673	ENSTRUP00000057781	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.454
CSDE1	LOC101067042	ENSTRUP00000080673	ENSTRUP00000049123	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.455
CSDE1	LOC101067191	ENSTRUP00000080673	ENSTRUP00000016050	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.509