88 items (Takifugu rubripes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fgf22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
	PTBP3	Polypyrimidine tract binding protein 3. (546 aa)
	TIAL1	TIA1 cytotoxic granule associated RNA binding protein like 1. (451 aa)
	LOC101062289	Cytotoxic granule-associated RNA binding protein 1, like. (386 aa)
	LOC115253205	PiggyBac transposable element-derived protein 4-like. (411 aa)
	cbl	Cbl proto-oncogene, E3 ubiquitin protein ligase. (951 aa)
	polr2c	Polymerase (RNA) II (DNA directed) polypeptide C. (315 aa)
	ENSTRUP00000064737	annotation not available (263 aa)
	LOC101071373	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	hnrnpm	Heterogeneous nuclear ribonucleoprotein M. (690 aa)
	mknk2	MAPK interacting serine/threonine kinase 2b; Belongs to the protein kinase superfamily. (474 aa)
	NCBP1	Nuclear cap binding protein subunit 1. (839 aa)
	ppp2r1b	Protein phosphatase 2, regulatory subunit A, beta b. (619 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (238 aa)
	polr2j	Polymerase (RNA) II (DNA directed) polypeptide J. (117 aa)
	ncbp2	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (173 aa)
	mknk1	MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (489 aa)
	LOC101069995	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (154 aa)
	LOC101066749	TFIIF_beta domain-containing protein. (146 aa)
	ENSTRUP00000078829	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (967 aa)
	LOC101065968	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (526 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (905 aa)
	TIA1	TIA1 cytotoxic granule associated RNA binding protein. (394 aa)
	LOC101065281	Tyrosine-protein kinase. (552 aa)
	ENSTRUP00000084773	annotation not available (1172 aa)
	shc4	SHC-transforming protein 4 isoform X2. (470 aa)
	fndc3b	Fibronectin type III domain containing 3Ba. (1224 aa)
	frs2	Fibroblast growth factor receptor substrate 2b. (1049 aa)
	polr2a	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1965 aa)
	H2SX87_TAKRU	Sprouty RTK signaling antagonist 2. (370 aa)
	ENSTRUP00000088182	annotation not available (138 aa)
	Fgfbp2	Fibroblast growth factor binding protein 2b. (213 aa)
	POLR2E	RNA polymerase II subunit E. (210 aa)
	src	Tyrosine-protein kinase. (552 aa)
	gtf2f2	General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (269 aa)
	LOC101067042	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	LOC101061204	Uncharacterized protein. (205 aa)
	polr2g	Polymerase (RNA) II (DNA directed) polypeptide G-like. (172 aa)
	polr2k	Uncharacterized protein. (85 aa)
	polr2i	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (198 aa)
	LOC101070196	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
	mapk1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (390 aa)
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	LOC101077619	Uncharacterized protein. (326 aa)
	kras	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (210 aa)
	ENSTRUP00000052849	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (148 aa)
	fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	LOC101073994	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (377 aa)
	polr2f	Polymerase (RNA) II (DNA directed) polypeptide F. (178 aa)
	shc1	SHC (Src homology 2 domain containing) transforming protein 1. (594 aa)
	fgf7	Fibroblast growth factor 7; Belongs to the heparin-binding growth factors family. (238 aa)
	fndc3a	Fibronectin type III domain containing 3A. (1253 aa)
	LOC101077836	Uncharacterized protein. (248 aa)
	LOC101066563	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (391 aa)
	plcg1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1314 aa)
	POLR2B	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	fgf10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
	polr2l	Polymerase (RNA) II (DNA directed) polypeptide L. (67 aa)
	LOC101078435	PH domain-containing protein. (744 aa)
	fgf17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (278 aa)
	fgfr2	Fibroblast growth factor receptor. (838 aa)
	LOC101070231	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
	LOC101074964	Fibroblast growth factor receptor substrate 3. (613 aa)
	gab1	GRB2-associated binding protein 1. (749 aa)
	LOC101070370	Uncharacterized protein. (862 aa)
	ptbp1	Polypyrimidine tract binding protein 1a. (562 aa)
	ppp2cb	Serine/threonine-protein phosphatase. (309 aa)
	FGF6-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa)
	LOC101061209	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (263 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	LOC115247179	Uncharacterized protein. (584 aa)
	esrp1	Epithelial splicing regulatory protein 1. (781 aa)
	grb2	Growth factor receptor-bound protein 2b. (220 aa)
	ppp2ca	Serine/threonine-protein phosphatase. (309 aa)
	LOC101064111	Epithelial splicing regulatory protein 2. (740 aa)
	polr2h	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
	fgfbp1	Fibroblast growth factor binding protein 1b. (207 aa)
	LOC101069736	Zgc:55558. (187 aa)
	LOC101067191	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC101079556	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (179 aa)
	polr2d	Polymerase (RNA) II (DNA directed) polypeptide D. (142 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC101064999	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	LOC101067940	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
	fgf5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (229 aa)

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	ENSTRUP00000052849	ENSTRUP00000080673	ENSTRUP00000052849	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.427
CSDE1	ENSTRUP00000078829	ENSTRUP00000080673	ENSTRUP00000078829	Cold shock domain containing E1, RNA-binding.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.509
CSDE1	LOC101061204	ENSTRUP00000080673	ENSTRUP00000049272	Cold shock domain containing E1, RNA-binding.	Uncharacterized protein.	0.593
CSDE1	LOC101061209	ENSTRUP00000080673	ENSTRUP00000027922	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.435
CSDE1	LOC101066563	ENSTRUP00000080673	ENSTRUP00000057781	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.454
CSDE1	LOC101067042	ENSTRUP00000080673	ENSTRUP00000049123	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.455
CSDE1	LOC101067191	ENSTRUP00000080673	ENSTRUP00000016050	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.509
CSDE1	LOC101067940	ENSTRUP00000080673	ENSTRUP00000003093	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	0.455
CSDE1	LOC101069995	ENSTRUP00000080673	ENSTRUP00000078224	Cold shock domain containing E1, RNA-binding.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.444
CSDE1	LOC101074964	ENSTRUP00000080673	ENSTRUP00000038716	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor receptor substrate 3.	0.443
CSDE1	LOC101079556	ENSTRUP00000080673	ENSTRUP00000012796	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.427
CSDE1	PIK3CA	ENSTRUP00000080673	ENSTRUP00000009530	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.509
CSDE1	fgf17	ENSTRUP00000080673	ENSTRUP00000044857	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.446
CSDE1	fgf3	ENSTRUP00000080673	ENSTRUP00000074114	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.466
CSDE1	fgf5	ENSTRUP00000080673	ENSTRUP00000002293	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.437
CSDE1	fgf7	ENSTRUP00000080673	ENSTRUP00000056954	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor 7; Belongs to the heparin-binding growth factors family.	0.453
CSDE1	fgf8	ENSTRUP00000080673	ENSTRUP00000058477	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.453
CSDE1	frs2	ENSTRUP00000080673	ENSTRUP00000086584	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor receptor substrate 2b.	0.443
CSDE1	grb2	ENSTRUP00000080673	ENSTRUP00000020659	Cold shock domain containing E1, RNA-binding.	Growth factor receptor-bound protein 2b.	0.593
CSDE1	mapk1	ENSTRUP00000080673	ENSTRUP00000051554	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.454