STRINGSTRING
eya4 eya4 rad50 rad50 brcc3 brcc3 uba52 uba52 nsd2 nsd2 LOC101062878 LOC101062878 baz1b baz1b rnf8 rnf8 rps27a rps27a LOC101072117 LOC101072117 eya3 eya3 H2U0M1_TAKRU H2U0M1_TAKRU LOC101079595 LOC101079595 mre11 mre11 LOC101079015 LOC101079015 chek2 chek2 smarca5 smarca5 ube2i ube2i ppp5c ppp5c LOC101068996 LOC101068996 kat5 kat5 pias4 pias4 abraxas1 abraxas1 ankrd11 ankrd11 LOC101063148 LOC101063148 brca1 brca1 ENSTRUP00000050752 ENSTRUP00000050752 LOC115248315 LOC115248315 LOC115253391 LOC115253391 LOC101068156 LOC101068156 LOC101068558 LOC101068558 LOC101063387 LOC101063387 LOC101072687 LOC101072687 babam1 babam1 LOC101068156-2 LOC101068156-2 ENSTRUP00000055871 ENSTRUP00000055871 ube2v2 ube2v2 LOC115248316 LOC115248316 LOC101068156-3 LOC101068156-3 LOC101074989 LOC101074989 ENSTRUP00000059378 ENSTRUP00000059378 ENSTRUP00000061189 ENSTRUP00000061189 sumo1 sumo1 ENSTRUP00000061711 ENSTRUP00000061711 ENSTRUP00000061761 ENSTRUP00000061761 abl1 abl1 RNF168 RNF168 ENSTRUP00000063541 ENSTRUP00000063541 ENSTRUP00000063639 ENSTRUP00000063639 ENSTRUP00000063810 ENSTRUP00000063810 atm atm eya1 eya1 babam2 babam2 ENSTRUP00000086695 ENSTRUP00000086695 ENSTRUP00000085886 ENSTRUP00000085886 ENSTRUP00000085627 ENSTRUP00000085627 ENSTRUP00000085448 ENSTRUP00000085448 ENSTRUP00000083601 ENSTRUP00000083601 ENSTRUP00000082854 ENSTRUP00000082854 ENSTRUP00000082823 ENSTRUP00000082823 LOC115248064 LOC115248064 LOC101065945 LOC101065945 ENSTRUP00000080653 ENSTRUP00000080653 LOC115248316-3 LOC115248316-3 ENSTRUP00000079500 ENSTRUP00000079500 LOC115248316-2 LOC115248316-2 ENSTRUP00000078869 ENSTRUP00000078869 ENSTRUP00000078617 ENSTRUP00000078617 ENSTRUP00000078201 ENSTRUP00000078201 ENSTRUP00000076769 ENSTRUP00000076769 ENSTRUP00000075951 ENSTRUP00000075951 ENSTRUP00000074977 ENSTRUP00000074977 ENSTRUP00000074749 ENSTRUP00000074749 ENSTRUP00000072164 ENSTRUP00000072164 LOC101078382 LOC101078382 ENSTRUP00000071049 ENSTRUP00000071049 ENSTRUP00000070036 ENSTRUP00000070036 ENSTRUP00000069326 ENSTRUP00000069326 kxd1 kxd1 rnf169 rnf169 LOC105416732 LOC105416732 ankrd12 ankrd12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
eya4Eyes absent homolog 4; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity); B [...] (664 aa)
rad50RAD50 homolog, double strand break repair protein. (1312 aa)
brcc3BRCA1/BRCA2-containing complex, subunit 3. (260 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
nsd2Nuclear receptor binding SET domain protein 2. (1353 aa)
LOC101062878Histone H2B; Belongs to the histone H2B family. (126 aa)
baz1bBromodomain adjacent to zinc finger domain, 1B. (1561 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (473 aa)
rps27aRibosomal protein S27a. (156 aa)
LOC101072117Histone H2A; Belongs to the histone H2A family. (138 aa)
eya3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (601 aa)
H2U0M1_TAKRUHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (100 aa)
LOC101079595Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (391 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (691 aa)
LOC101079015Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (476 aa)
chek2Checkpoint kinase 2. (538 aa)
smarca5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1035 aa)
ube2iUbiquitin-conjugating enzyme E2Ia; Belongs to the ubiquitin-conjugating enzyme family. (187 aa)
ppp5cSerine/threonine-protein phosphatase. (498 aa)
LOC101068996UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (580 aa)
pias4Protein inhibitor of activated STAT, 4a. (502 aa)
abraxas1Abraxas 1, BRCA1 A complex subunit. (387 aa)
ankrd11Ankyrin repeat domain 11. (2841 aa)
LOC101063148Histone H2B; Belongs to the histone H2B family. (67 aa)
brca1Uncharacterized protein. (1338 aa)
ENSTRUP00000050752Histone H2B; Belongs to the histone H2B family. (238 aa)
LOC115248315Histone H2B; Belongs to the histone H2B family. (124 aa)
LOC115253391Histone H2B; Belongs to the histone H2B family. (125 aa)
LOC101068156Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC101068558Histone H2B; Belongs to the histone H2B family. (125 aa)
LOC101063387Histone H2B; Belongs to the histone H2B family. (116 aa)
LOC101072687UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
babam1BRISC and BRCA1 A complex member 1. (378 aa)
LOC101068156-2Histone H4. (103 aa)
ENSTRUP00000055871annotation not available (95 aa)
ube2v2Ubiquitin-conjugating enzyme E2 variant 2. (155 aa)
LOC115248316Histone H2B; Belongs to the histone H2B family. (124 aa)
LOC101068156-3Histone H4. (103 aa)
LOC101074989Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (95 aa)
ENSTRUP00000059378annotation not available (93 aa)
ENSTRUP00000061189annotation not available (224 aa)
sumo1Small ubiquitin-related modifier. (110 aa)
ENSTRUP00000061711annotation not available (1043 aa)
ENSTRUP00000061761annotation not available (258 aa)
abl1Tyrosine-protein kinase. (1115 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (128 aa)
ENSTRUP00000063541Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
ENSTRUP00000063639annotation not available (332 aa)
ENSTRUP00000063810Zgc:163040. (95 aa)
atmTAN domain-containing protein. (3087 aa)
eya1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (636 aa)
babam2BRISC and BRCA1 A complex member 2. (470 aa)
ENSTRUP00000086695annotation not available (282 aa)
ENSTRUP00000085886annotation not available (572 aa)
ENSTRUP00000085627Poly [ADP-ribose] polymerase tankyrase-like. (548 aa)
ENSTRUP00000085448annotation not available (477 aa)
ENSTRUP00000083601annotation not available (89 aa)
ENSTRUP00000082854annotation not available (312 aa)
ENSTRUP00000082823annotation not available (323 aa)
LOC115248064LOW QUALITY PROTEIN: uncharacterized protein LOC115248064. (846 aa)
LOC101065945Lysine (K)-specific demethylase 4B. (1207 aa)
ENSTRUP00000080653annotation not available (98 aa)
LOC115248316-3Histone H2B 1/2-like. (124 aa)
ENSTRUP00000079500annotation not available (578 aa)
LOC115248316-2Histone H2B 1/2-like. (124 aa)
ENSTRUP00000078869Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
ENSTRUP00000078617annotation not available (248 aa)
ENSTRUP00000078201annotation not available (398 aa)
ENSTRUP00000076769annotation not available (1312 aa)
ENSTRUP00000075951annotation not available (94 aa)
ENSTRUP00000074977annotation not available (93 aa)
ENSTRUP00000074749annotation not available (128 aa)
ENSTRUP00000072164annotation not available (949 aa)
LOC101078382Ubiquitin-conjugating enzyme E2Na; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
ENSTRUP00000071049annotation not available (95 aa)
ENSTRUP00000070036annotation not available (89 aa)
ENSTRUP00000069326annotation not available (777 aa)
kxd1KxDL motif containing 1. (194 aa)
rnf169Ring finger protein 169. (543 aa)
LOC105416732Mediator of DNA damage checkpoint protein 1. (1666 aa)
ankrd12ANK_REP_REGION domain-containing protein. (1894 aa)
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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