STRINGSTRING
orc1 orc1 ube2s ube2s LOC101077988 LOC101077988 rpa1 rpa1 anapc2 anapc2 cdc7 cdc7 H2RXN1_TAKRU H2RXN1_TAKRU LOC101077756 LOC101077756 psma5 psma5 H2AZ1 H2AZ1 psmb6 psmb6 LOC101075221 LOC101075221 LOC101076451 LOC101076451 pole4 pole4 cdc27 cdc27 kpnb1 kpnb1 H2S5K4_TAKRU H2S5K4_TAKRU psmb4 psmb4 RPA1 RPA1 mcm4 mcm4 LOC101063521-2 LOC101063521-2 LOC101074545 LOC101074545 mcm6 mcm6 psmc1 psmc1 cdc6 cdc6 mcm7 mcm7 ENSTRUP00000084610 ENSTRUP00000084610 ube2e1 ube2e1 ENSTRUP00000084390 ENSTRUP00000084390 LOC101067241 LOC101067241 ENSTRUP00000084116 ENSTRUP00000084116 ube2c ube2c ENSTRUP00000084018 ENSTRUP00000084018 LOC101065848 LOC101065848 ENSTRUP00000083601 ENSTRUP00000083601 LOC101062380 LOC101062380 kpna1 kpna1 LOC101069157-2 LOC101069157-2 pole3 pole3 LOC105417201 LOC105417201 ENSTRUP00000080653 ENSTRUP00000080653 LOC101069157 LOC101069157 LOC115248316-3 LOC115248316-3 GMNN GMNN cdk2 cdk2 LOC115248316-2 LOC115248316-2 ENSTRUP00000078869 ENSTRUP00000078869 LOC101067696-4 LOC101067696-4 ENSTRUP00000074977 ENSTRUP00000074977 psmb5 psmb5 bicra bicra rpa2 rpa2 LOC101069186 LOC101069186 LOC101067696-3 LOC101067696-3 ENSTRUP00000073536 ENSTRUP00000073536 ENSTRUP00000071049 ENSTRUP00000071049 kpna6 kpna6 H2SAU2_TAKRU H2SAU2_TAKRU kxd1 kxd1 anapc7 anapc7 anapc11 anapc11 orc2 orc2 psmd12 psmd12 ENSTRUP00000063810 ENSTRUP00000063810 ENSTRUP00000063766 ENSTRUP00000063766 ENSTRUP00000063541 ENSTRUP00000063541 psmb8 psmb8 LOC101061681-2 LOC101061681-2 ENSTRUP00000063087 ENSTRUP00000063087 psmb7 psmb7 psme3 psme3 LOC101067696-2 LOC101067696-2 LOC101068229 LOC101068229 ENSTRUP00000061189 ENSTRUP00000061189 prim1 prim1 tm7sf3 tm7sf3 psmc6 psmc6 ENSTRUP00000060235 ENSTRUP00000060235 ENSTRUP00000059378 ENSTRUP00000059378 LOC101074989 LOC101074989 mcm3 mcm3 ENSTRUP00000058649 ENSTRUP00000058649 psmb3 psmb3 Mcm9 Mcm9 psmd9 psmd9 psmb2 psmb2 LOC101061681 LOC101061681 LOC101068156-3 LOC101068156-3 LOC101071831 LOC101071831 LOC115248316 LOC115248316 rpa3 rpa3 LOC101068314 LOC101068314 ENSTRUP00000056504 ENSTRUP00000056504 LOC101067696 LOC101067696 LOC101080230 LOC101080230 ENSTRUP00000055871 ENSTRUP00000055871 mcm5 mcm5 FZR1 FZR1 LOC101073150 LOC101073150 LOC101068156-2 LOC101068156-2 psmd7 psmd7 ENSTRUP00000054961 ENSTRUP00000054961 orc4 orc4 ENSTRUP00000053968 ENSTRUP00000053968 psmd2 psmd2 ENSTRUP00000053371 ENSTRUP00000053371 LOC101071855 LOC101071855 pole pole LOC101063387 LOC101063387 anapc16 anapc16 LOC101063521 LOC101063521 LOC101068558 LOC101068558 LOC101068156 LOC101068156 ENSTRUP00000052153 ENSTRUP00000052153 LOC105417929 LOC105417929 psmd10 psmd10 LOC115253391 LOC115253391 LOC101061620 LOC101061620 LOC115248315 LOC115248315 ENSTRUP00000050752 ENSTRUP00000050752 ENSTRUP00000049880 ENSTRUP00000049880 ENSTRUP00000049431 ENSTRUP00000049431 LOC101066780 LOC101066780 LOC101075392 LOC101075392 cdc16 cdc16 LOC101070924 LOC101070924 LOC101063148 LOC101063148 LOC101068629 LOC101068629 psmd5 psmd5 bicral bicral anapc10 anapc10 psmd1 psmd1 H2V558_TAKRU H2V558_TAKRU psmd14 psmd14 meiob meiob cdc23 cdc23 psma4 psma4 cdc45 cdc45 anapc5 anapc5 prim2 prim2 orc5 orc5 pola2 pola2 anapc4 anapc4 LOC101065302 LOC101065302 pole2 pole2 psmd13 psmd13 H2U0M1_TAKRU H2U0M1_TAKRU LOC101072117 LOC101072117 rps27a rps27a psmd8 psmd8 LOC101078394 LOC101078394 psmd6 psmd6 psma1 psma1 psma3 psma3 H2T664_TAKRU H2T664_TAKRU pola1 pola1 mcm8 mcm8 psmb1 psmb1 psmc3 psmc3 mcm2 mcm2 LOC101074926 LOC101074926 psmc4 psmc4 orc3 orc3 psme1 psme1 LOC101062878 LOC101062878 LOC115246432 LOC115246432 uba52 uba52
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (898 aa)
ube2sUbiquitin-conjugating enzyme E2S; Belongs to the ubiquitin-conjugating enzyme family. (232 aa)
LOC101077988Proteasome subunit beta 12. (217 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (600 aa)
anapc2Anaphase promoting complex subunit 2; Belongs to the cullin family. (817 aa)
cdc7Cell division cycle 7 homolog (S. cerevisiae). (534 aa)
H2RXN1_TAKRUUncharacterized protein. (105 aa)
LOC101077756Proteasome subunit beta. (275 aa)
psma5Proteasome subunit alpha type. (244 aa)
H2AZ1Histone H2A; Belongs to the histone H2A family. (131 aa)
psmb6Proteasome subunit beta. (226 aa)
LOC101075221Anaphase promoting complex subunit 1. (1895 aa)
LOC101076451Fizzy/cell division cycle 20 related 1b. (487 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (130 aa)
cdc27Cell division cycle 27. (839 aa)
kpnb1Karyopherin (importin) beta 1. (876 aa)
H2S5K4_TAKRUUncharacterized protein. (147 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (259 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (713 aa)
mcm4DNA helicase; Belongs to the MCM family. (869 aa)
LOC101063521-2Histone H3.3. (151 aa)
LOC101074545Histone H2A; Belongs to the histone H2A family. (151 aa)
mcm6DNA helicase; Belongs to the MCM family. (826 aa)
psmc1Proteasome 26S subunit, ATPase 1b; Belongs to the AAA ATPase family. (443 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (574 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (732 aa)
ENSTRUP00000084610annotation not available (122 aa)
ube2e1UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (281 aa)
ENSTRUP00000084390Proteasome 20S subunit beta 8A. (105 aa)
LOC101067241Proteasome 26S subunit, non-ATPase 4b. (374 aa)
ENSTRUP00000084116annotation not available (138 aa)
ube2cUncharacterized protein. (301 aa)
ENSTRUP00000084018annotation not available (138 aa)
LOC101065848Proteasome subunit beta 9a. (216 aa)
ENSTRUP00000083601annotation not available (89 aa)
LOC101062380Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (425 aa)
kpna1Importin subunit alpha; Belongs to the importin alpha family. (571 aa)
LOC101069157-2Proteasome subunit alpha type-6. (266 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (144 aa)
LOC105417201Proteasome 26S subunit, non-ATPase 4a. (376 aa)
ENSTRUP00000080653annotation not available (98 aa)
LOC101069157Proteasome subunit alpha type. (246 aa)
LOC115248316-3Histone H2B 1/2-like. (124 aa)
GMNNGeminin DNA replication inhibitor. (223 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
LOC115248316-2Histone H2B 1/2-like. (124 aa)
ENSTRUP00000078869Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
LOC101067696-4Histone H2A. (125 aa)
ENSTRUP00000074977annotation not available (93 aa)
psmb5Proteasome subunit beta. (288 aa)
bicraBRD4 interacting chromatin remodeling complex associated protein. (1892 aa)
rpa2Replication protein A2. (280 aa)
LOC101069186Proteasome 26S subunit, non-ATPase 11b. (500 aa)
LOC101067696-3Histone H2A. (125 aa)
ENSTRUP00000073536annotation not available (91 aa)
ENSTRUP00000071049annotation not available (95 aa)
kpna6Importin subunit alpha; Belongs to the importin alpha family. (559 aa)
H2SAU2_TAKRUUncharacterized protein. (183 aa)
kxd1KxDL motif containing 1. (194 aa)
anapc7Anaphase promoting complex subunit 7. (567 aa)
anapc11APC11 anaphase promoting complex subunit 11 homolog (yeast). (84 aa)
orc2Origin recognition complex, subunit 2. (601 aa)
psmd12Proteasome 26S subunit, non-ATPase 12. (457 aa)
ENSTRUP00000063810Zgc:163040. (95 aa)
ENSTRUP00000063766annotation not available (165 aa)
ENSTRUP00000063541Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
psmb8Proteasome subunit beta. (275 aa)
LOC101061681-2Protein FAM89A-like. (217 aa)
ENSTRUP00000063087annotation not available (105 aa)
psmb7Proteasome subunit beta. (280 aa)
psme3Proteasome activator subunit 3. (258 aa)
LOC101067696-2Histone H2A. (125 aa)
LOC101068229Proteasome 26S subunit, non-ATPase 3. (516 aa)
ENSTRUP00000061189annotation not available (224 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (425 aa)
tm7sf3Transmembrane 7 superfamily member 3. (620 aa)
psmc6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (411 aa)
ENSTRUP00000060235annotation not available (105 aa)
ENSTRUP00000059378annotation not available (93 aa)
LOC101074989Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (95 aa)
mcm3DNA helicase; Belongs to the MCM family. (813 aa)
ENSTRUP00000058649Histone H2A; Belongs to the histone H2A family. (130 aa)
psmb3Proteasome subunit beta. (206 aa)
Mcm9MCM_OB domain-containing protein. (683 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (226 aa)
psmb2Proteasome subunit beta. (199 aa)
LOC101061681Family with sequence similarity 89 member A. (172 aa)
LOC101068156-3Histone H4. (103 aa)
LOC101071831Histone H2A-like. (125 aa)
LOC115248316Histone H2B; Belongs to the histone H2B family. (124 aa)
rpa3Replication protein A3. (122 aa)
LOC101068314Histone H3. (139 aa)
ENSTRUP00000056504annotation not available (141 aa)
LOC101067696Histone H2A; Belongs to the histone H2A family. (125 aa)
LOC101080230Histone H2A; Belongs to the histone H2A family. (128 aa)
ENSTRUP00000055871annotation not available (95 aa)
mcm5DNA helicase; Belongs to the MCM family. (737 aa)
FZR1Fizzy/cell division cycle 20 related 1a. (496 aa)
LOC101073150PROTEASOME_ALPHA_1 domain-containing protein. (246 aa)
LOC101068156-2Histone H4. (103 aa)
psmd7Proteasome 26S subunit, non-ATPase 7. (329 aa)
ENSTRUP00000054961Histone H3; Belongs to the histone H3 family. (157 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (538 aa)
ENSTRUP00000053968Uncharacterized protein. (121 aa)
psmd226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (913 aa)
ENSTRUP00000053371Cell division cycle 26 homolog. (96 aa)
LOC101071855Chromatin licensing and DNA replication factor 1. (657 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2290 aa)
LOC101063387Histone H2B; Belongs to the histone H2B family. (116 aa)
anapc16Anaphase promoting complex subunit 16. (143 aa)
LOC101063521Histone H3; Belongs to the histone H3 family. (136 aa)
LOC101068558Histone H2B; Belongs to the histone H2B family. (125 aa)
LOC101068156Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
ENSTRUP00000052153Histone H3; Belongs to the histone H3 family. (97 aa)
LOC105417929SCY domain-containing protein. (126 aa)
psmd10Proteasome 26S subunit, non-ATPase 10. (228 aa)
LOC115253391Histone H2B; Belongs to the histone H2B family. (125 aa)
LOC101061620Histone domain-containing protein. (155 aa)
LOC115248315Histone H2B; Belongs to the histone H2B family. (124 aa)
ENSTRUP00000050752Histone H2B; Belongs to the histone H2B family. (238 aa)
ENSTRUP00000049880Histone H3; Belongs to the histone H3 family. (95 aa)
ENSTRUP00000049431Histone H3; Belongs to the histone H3 family. (101 aa)
LOC101066780PCI domain-containing protein. (424 aa)
LOC101075392Histone H2A type 1-H. (124 aa)
cdc16Cell division cycle 16 homolog (S. cerevisiae). (620 aa)
LOC101070924Histone H3; Belongs to the histone H3 family. (138 aa)
LOC101063148Histone H2B; Belongs to the histone H2B family. (67 aa)
LOC101068629Histone H2A; Belongs to the histone H2A family. (142 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (466 aa)
bicralBRD4 interacting chromatin remodeling complex associated protein like. (781 aa)
anapc10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (182 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (958 aa)
H2V558_TAKRUHistone H3; Belongs to the histone H3 family. (128 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (332 aa)
meiobMethionine sulfoxide reductase B1b. (483 aa)
cdc23CDC23 (cell division cycle 23, yeast, homolog). (587 aa)
psma4Proteasome subunit alpha type. (261 aa)
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae). (568 aa)
anapc5Anaphase promoting complex subunit 5. (770 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (504 aa)
orc5Origin recognition complex, subunit 5. (460 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
anapc4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (813 aa)
LOC101065302Geminin. (226 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
psmd13Proteasome 26S subunit, non-ATPase 13. (392 aa)
H2U0M1_TAKRUHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (100 aa)
LOC101072117Histone H2A; Belongs to the histone H2A family. (138 aa)
rps27aRibosomal protein S27a. (156 aa)
psmd8Proteasome 26S subunit, non-ATPase 8. (277 aa)
LOC101078394RPA_C domain-containing protein. (224 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (389 aa)
psma1Proteasome subunit alpha type. (263 aa)
psma3Proteasome subunit alpha type. (255 aa)
H2T664_TAKRUHistone H3; Belongs to the histone H3 family. (124 aa)
pola1DNA polymerase. (1467 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (874 aa)
psmb1Proteasome subunit beta. (243 aa)
psmc3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (427 aa)
mcm2DNA helicase; Belongs to the MCM family. (896 aa)
LOC101074926Proteasome subunit beta. (280 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (417 aa)
orc3Origin recognition complex, subunit 3. (716 aa)
psme1Proteasome activator subunit 1. (249 aa)
LOC101062878Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC115246432Chromatin licensing and DNA replication factor 1. (619 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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