STRINGSTRING
mcm3 mcm3 ENSTRUP00000073536 ENSTRUP00000073536 ENSTRUP00000073787 ENSTRUP00000073787 LOC101069186 LOC101069186 rfc5 rfc5 mcm4 mcm4 LOC101071855 LOC101071855 pole pole anapc16 anapc16 LOC105417929 LOC105417929 psmd10 psmd10 fen1 fen1 ccna2 ccna2 gins2 gins2 LOC101070845 LOC101070845 psmb4 psmb4 LOC101063185 LOC101063185 RPA1 RPA1 H2S5K4_TAKRU H2S5K4_TAKRU cdc27 cdc27 pole4 pole4 ENSTRUP00000060235 ENSTRUP00000060235 psmc6 psmc6 tm7sf3 tm7sf3 dna2 dna2 prim1 prim1 LOC101068229 LOC101068229 LOC115248454 LOC115248454 psme3 psme3 psmb7 psmb7 ENSTRUP00000063087 ENSTRUP00000063087 LOC101061681-2 LOC101061681-2 psmb8 psmb8 ENSTRUP00000063766 ENSTRUP00000063766 psmd12 psmd12 orc2 orc2 anapc11 anapc11 anapc7 anapc7 rfc3 rfc3 gins3 gins3 pold4 pold4 LOC101066780 LOC101066780 cdc16 cdc16 psmd5 psmd5 bicral bicral anapc10 anapc10 psmd1 psmd1 psmd14 psmd14 meiob meiob cdc23 cdc23 psma4 psma4 psme4 psme4 anapc5 anapc5 prim2 prim2 orc5 orc5 pola2 pola2 anapc4 anapc4 LOC101065302 LOC101065302 LOC101069462 LOC101069462 pole2 pole2 H2U2H7_TAKRU H2U2H7_TAKRU psmd13 psmd13 rps27a rps27a psmd8 psmd8 rfc2 rfc2 LOC101078394 LOC101078394 psmd6 psmd6 rfc1 rfc1 psma1 psma1 LOC101062730 LOC101062730 psma3 psma3 skp1 skp1 pola1 pola1 mcm8 mcm8 ccne2 ccne2 mcm6 mcm6 psmb1 psmb1 psmc3 psmc3 mcm2 mcm2 LOC101074926 LOC101074926 psmc4 psmc4 gins1 gins1 orc3 orc3 pold2 pold2 rfc4 rfc4 psme1 psme1 LOC115246432 LOC115246432 uba52 uba52 orc1 orc1 ube2s ube2s LOC101077988 LOC101077988 rpa1 rpa1 anapc2 anapc2 gins4 gins4 H2RXN1_TAKRU H2RXN1_TAKRU LOC101077756 LOC101077756 psma5 psma5 LOC101063185-2 LOC101063185-2 pold3 pold3 psmb6 psmb6 ENSTRUP00000002993 ENSTRUP00000002993 LOC101075221 LOC101075221 LOC101076451 LOC101076451 rpa2 rpa2 bicra bicra psmb5 psmb5 ccna1 ccna1 cdk2 cdk2 GMNN GMNN LOC101069157 LOC101069157 LOC105417201 LOC105417201 ENSTRUP00000080931 ENSTRUP00000080931 pole3 pole3 LOC101069157-2 LOC101069157-2 LOC101062380 LOC101062380 ENSTRUP00000083798 ENSTRUP00000083798 LOC101065848 LOC101065848 LOC115251941 LOC115251941 ube2c ube2c LOC101067241 LOC101067241 ENSTRUP00000084390 ENSTRUP00000084390 ube2e1 ube2e1 rcbtb2 rcbtb2 mcm7 mcm7 cdc6 cdc6 psmc1 psmc1 LOC101065632 LOC101065632 ENSTRUP00000067332 ENSTRUP00000067332 pold1 pold1 kxd1 kxd1 H2SAU2_TAKRU H2SAU2_TAKRU LOC101079814 LOC101079814 ENSTRUP00000073355 ENSTRUP00000073355 pcna pcna ENSTRUP00000053371 ENSTRUP00000053371 ENSTRUP00000053968 ENSTRUP00000053968 orc4 orc4 psmd7 psmd7 LOC101073150 LOC101073150 skp2 skp2 FZR1 FZR1 mcm5 mcm5 RCBTB1 RCBTB1 rpa3 rpa3 LOC101061681 LOC101061681 psmb2 psmb2 psmd9 psmd9 Mcm9 Mcm9 psmb3 psmb3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mcm3DNA helicase; Belongs to the MCM family. (813 aa)
ENSTRUP00000073536annotation not available (91 aa)
ENSTRUP00000073787annotation not available (310 aa)
LOC101069186Proteasome 26S subunit, non-ATPase 11b. (500 aa)
rfc5Replication factor C (activator 1) 5. (338 aa)
mcm4DNA helicase; Belongs to the MCM family. (869 aa)
LOC101071855Chromatin licensing and DNA replication factor 1. (657 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2290 aa)
anapc16Anaphase promoting complex subunit 16. (143 aa)
LOC105417929SCY domain-containing protein. (126 aa)
psmd10Proteasome 26S subunit, non-ATPase 10. (228 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (381 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (459 aa)
gins2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
LOC101070845Zgc:110269. (320 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (259 aa)
LOC101063185Uncharacterized protein; Belongs to the cyclin family. (380 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (713 aa)
H2S5K4_TAKRUUncharacterized protein. (147 aa)
cdc27Cell division cycle 27. (839 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (130 aa)
ENSTRUP00000060235annotation not available (105 aa)
psmc6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (411 aa)
tm7sf3Transmembrane 7 superfamily member 3. (620 aa)
dna2DNA replication helicase/nuclease 2. (1376 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (425 aa)
LOC101068229Proteasome 26S subunit, non-ATPase 3. (516 aa)
LOC115248454RING-box protein 1. (126 aa)
psme3Proteasome activator subunit 3. (258 aa)
psmb7Proteasome subunit beta. (280 aa)
ENSTRUP00000063087annotation not available (105 aa)
LOC101061681-2Protein FAM89A-like. (217 aa)
psmb8Proteasome subunit beta. (275 aa)
ENSTRUP00000063766annotation not available (165 aa)
psmd12Proteasome 26S subunit, non-ATPase 12. (457 aa)
orc2Origin recognition complex, subunit 2. (601 aa)
anapc11APC11 anaphase promoting complex subunit 11 homolog (yeast). (84 aa)
anapc7Anaphase promoting complex subunit 7. (567 aa)
rfc3Replication factor C (activator 1) 3. (410 aa)
gins3GINS complex subunit 3. (211 aa)
pold4Si:dkey-28b4.7. (107 aa)
LOC101066780PCI domain-containing protein. (424 aa)
cdc16Cell division cycle 16 homolog (S. cerevisiae). (620 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (466 aa)
bicralBRD4 interacting chromatin remodeling complex associated protein like. (781 aa)
anapc10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (182 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (958 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (332 aa)
meiobMethionine sulfoxide reductase B1b. (483 aa)
cdc23CDC23 (cell division cycle 23, yeast, homolog). (587 aa)
psma4Proteasome subunit alpha type. (261 aa)
psme4Proteasome activator subunit 4a. (1828 aa)
anapc5Anaphase promoting complex subunit 5. (770 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (504 aa)
orc5Origin recognition complex, subunit 5. (460 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
anapc4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (813 aa)
LOC101065302Geminin. (226 aa)
LOC101069462Proteasome subunit beta. (283 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
H2U2H7_TAKRUUncharacterized protein. (718 aa)
psmd13Proteasome 26S subunit, non-ATPase 13. (392 aa)
rps27aRibosomal protein S27a. (156 aa)
psmd8Proteasome 26S subunit, non-ATPase 8. (277 aa)
rfc2Replication factor C (activator 1) 2. (350 aa)
LOC101078394RPA_C domain-containing protein. (224 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (389 aa)
rfc1Replication factor C subunit 1. (1157 aa)
psma1Proteasome subunit alpha type. (263 aa)
LOC101062730Proteasome subunit alpha type. (251 aa)
psma3Proteasome subunit alpha type. (255 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
pola1DNA polymerase. (1467 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (874 aa)
ccne2Cyclin E2; Belongs to the cyclin family. (416 aa)
mcm6DNA helicase; Belongs to the MCM family. (826 aa)
psmb1Proteasome subunit beta. (243 aa)
psmc3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (427 aa)
mcm2DNA helicase; Belongs to the MCM family. (896 aa)
LOC101074926Proteasome subunit beta. (280 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (417 aa)
gins1GINS complex subunit 1 (Psf1 homolog). (171 aa)
orc3Origin recognition complex, subunit 3. (716 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa)
rfc4Replication factor C (activator 1) 4. (357 aa)
psme1Proteasome activator subunit 1. (249 aa)
LOC115246432Chromatin licensing and DNA replication factor 1. (619 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (898 aa)
ube2sUbiquitin-conjugating enzyme E2S; Belongs to the ubiquitin-conjugating enzyme family. (232 aa)
LOC101077988Proteasome subunit beta 12. (217 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (600 aa)
anapc2Anaphase promoting complex subunit 2; Belongs to the cullin family. (817 aa)
gins4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (224 aa)
H2RXN1_TAKRUUncharacterized protein. (105 aa)
LOC101077756Proteasome subunit beta. (275 aa)
psma5Proteasome subunit alpha type. (244 aa)
LOC101063185-2Uncharacterized protein; Belongs to the cyclin family. (281 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (439 aa)
psmb6Proteasome subunit beta. (226 aa)
ENSTRUP00000002993annotation not available (368 aa)
LOC101075221Anaphase promoting complex subunit 1. (1895 aa)
LOC101076451Fizzy/cell division cycle 20 related 1b. (487 aa)
rpa2Replication protein A2. (280 aa)
bicraBRD4 interacting chromatin remodeling complex associated protein. (1892 aa)
psmb5Proteasome subunit beta. (288 aa)
ccna1Cyclin-A1 isoform X1. (414 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
GMNNGeminin DNA replication inhibitor. (223 aa)
LOC101069157Proteasome subunit alpha type. (246 aa)
LOC105417201Proteasome 26S subunit, non-ATPase 4a. (376 aa)
ENSTRUP00000080931Ligase I, DNA, ATP-dependent. (540 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (144 aa)
LOC101069157-2Proteasome subunit alpha type-6. (266 aa)
LOC101062380Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (425 aa)
ENSTRUP00000083798annotation not available (222 aa)
LOC101065848Proteasome subunit beta 9a. (216 aa)
LOC115251941Cyclin E1; Belongs to the cyclin family. (502 aa)
ube2cUncharacterized protein. (301 aa)
LOC101067241Proteasome 26S subunit, non-ATPase 4b. (374 aa)
ENSTRUP00000084390Proteasome 20S subunit beta 8A. (105 aa)
ube2e1UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (281 aa)
rcbtb2Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (550 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (732 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (574 aa)
psmc1Proteasome 26S subunit, ATPase 1b; Belongs to the AAA ATPase family. (443 aa)
LOC101065632G1/S-specific cyclin-E1-like isoform X1. (502 aa)
ENSTRUP00000067332Cyclin E1. (364 aa)
pold1DNA polymerase. (1112 aa)
kxd1KxDL motif containing 1. (194 aa)
H2SAU2_TAKRUUncharacterized protein. (183 aa)
LOC101079814Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
ENSTRUP00000073355Replication factor C (activator 1) 3. (228 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
ENSTRUP00000053371Cell division cycle 26 homolog. (96 aa)
ENSTRUP00000053968Uncharacterized protein. (121 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (538 aa)
psmd7Proteasome 26S subunit, non-ATPase 7. (329 aa)
LOC101073150PROTEASOME_ALPHA_1 domain-containing protein. (246 aa)
skp2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (480 aa)
FZR1Fizzy/cell division cycle 20 related 1a. (496 aa)
mcm5DNA helicase; Belongs to the MCM family. (737 aa)
RCBTB1Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (620 aa)
rpa3Replication protein A3. (122 aa)
LOC101061681Family with sequence similarity 89 member A. (172 aa)
psmb2Proteasome subunit beta. (199 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (226 aa)
Mcm9MCM_OB domain-containing protein. (683 aa)
psmb3Proteasome subunit beta. (206 aa)
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
Server load: low (22%) [HD]