(20 nodes) (2005) Functional evolution of ADAMTS genes: evidence from analyses of phylogeny and gene organization. network (Takifugu rubripes)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	adamts18	ADAM metallopeptidase with thrombospondin type 1 motif, 18. (1249 aa)
	thbs1	Uncharacterized protein. (1174 aa)
	adamts15	ADAM metallopeptidase with thrombospondin type 1 motif, 15b. (923 aa)
	adamts8	ADAM metallopeptidase with thrombospondin type 1 motif, 15b. (937 aa)
	LOC101067296	ADAM metallopeptidase with thrombospondin type 1 motif, 10. (1106 aa)
	vwf	Uncharacterized protein. (2818 aa)
	adamts14	ADAM metallopeptidase with thrombospondin type 1 motif, 14. (1232 aa)
	LOC101078322	Furin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family. (828 aa)
	ADAMTS20	ADAM metallopeptidase with thrombospondin type 1 motif 20. (1898 aa)
	adamts16	ADAM metallopeptidase with thrombospondin type 1 motif, 16. (1274 aa)
	adamts6	ADAM metallopeptidase with thrombospondin type 1 motif, 6. (1168 aa)
	adamts13	Uncharacterized protein. (1365 aa)
	papln	Papilin isoform X1. (1213 aa)
	ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif 2. (1670 aa)
	ADAMTS7	ADAM metallopeptidase with thrombospondin type 1 motif 7. (1740 aa)
	adamts9	ADAM metallopeptidase with thrombospondin type 1 motif, 9. (1910 aa)
	LOC101061571	Furin (paired basic amino acid cleaving enzyme) b; Belongs to the peptidase S8 family. (835 aa)
	LOC101062487	Thrombospondin 1b. (1182 aa)
	adamts12	Peptidase M12B domain-containing protein. (1617 aa)
	il1b	Interleukin-1; Belongs to the IL-1 family. (256 aa)

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS2	vwf	ENSTRUP00000070817	ENSTRUP00000004319	ADAM metallopeptidase with thrombospondin type 1 motif 2.	Uncharacterized protein.	0.427
LOC101062487	thbs1	ENSTRUP00000077773	ENSTRUP00000037248	Thrombospondin 1b.	Uncharacterized protein.	0.901
adamts13	vwf	ENSTRUP00000069364	ENSTRUP00000004319	Uncharacterized protein.	Uncharacterized protein.	0.693
adamts14	adamts8	ENSTRUP00000058663	ENSTRUP00000029499	ADAM metallopeptidase with thrombospondin type 1 motif, 14.	ADAM metallopeptidase with thrombospondin type 1 motif, 15b.	0.418
adamts8	adamts14	ENSTRUP00000029499	ENSTRUP00000058663	ADAM metallopeptidase with thrombospondin type 1 motif, 15b.	ADAM metallopeptidase with thrombospondin type 1 motif, 14.	0.418
thbs1	LOC101062487	ENSTRUP00000037248	ENSTRUP00000077773	Uncharacterized protein.	Thrombospondin 1b.	0.901
vwf	ADAMTS2	ENSTRUP00000004319	ENSTRUP00000070817	Uncharacterized protein.	ADAM metallopeptidase with thrombospondin type 1 motif 2.	0.427
vwf	adamts13	ENSTRUP00000004319	ENSTRUP00000069364	Uncharacterized protein.	Uncharacterized protein.	0.693