STRINGSTRING
cd40 cd40 tab2 tab2 atm atm LOC101061159-2 LOC101061159-2 blnk blnk FAIM2 FAIM2 LOC101066987 LOC101066987 LOC101074026 LOC101074026 LOC101062695 LOC101062695 LOC101074428 LOC101074428 wap65-2 wap65-2 LOC105418743 LOC105418743 LOC101064045 LOC101064045 LOC101067723 LOC101067723 LOC101067856 LOC101067856 H2SH89_TAKRU H2SH89_TAKRU LOC101072985 LOC101072985 rabif rabif LOC101069822 LOC101069822 TOLLIP TOLLIP map2k2 map2k2 sos2 sos2 LOC101078862 LOC101078862 c9 c9 irf5 irf5 LOC101066292 LOC101066292 btk btk RASGRP1 RASGRP1 apaf1 apaf1 LOC101075779 LOC101075779 LOC101066992 LOC101066992 itk itk LOC101067067 LOC101067067 LOC101061159 LOC101061159 LOC105418528 LOC105418528 LOC101078355 LOC101078355 plcg1 plcg1 casp7 casp7 pten pten myd88 myd88 irak4 irak4 il-18 il-18 tlr3 tlr3 LOC101077059 LOC101077059 traf2 traf2 meltf meltf tradd tradd casp9 casp9 plcg2 plcg2 tirap tirap LOC101061773 LOC101061773 LOC101064444 LOC101064444 traf3 traf3 LOC101077601 LOC101077601 pak1 pak1 LOC101072918 LOC101072918 tlr5 tlr5 lck lck apo14kDa apo14kDa fyn fyn tlr2 tlr2 LOC101075537 LOC101075537 LOC101067377 LOC101067377 il1b il1b LOC101065354 LOC101065354 CASP3 CASP3 bcr bcr LOC101076070 LOC101076070 hpx hpx ticam ticam SOS1 SOS1 LOC101064315 LOC101064315 habp2 habp2 Il-18 Il-18 LOC101071639 LOC101071639 prkcq prkcq c3 c3 casp8 casp8 mtor mtor casp6 casp6 grb2 grb2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cd40CD40. (307 aa)
tab2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (748 aa)
atmTAN domain-containing protein. (3087 aa)
LOC101061159-2CD81 antigen-like. (282 aa)
blnkB cell linker. (165 aa)
FAIM2Fas apoptotic inhibitory molecule 2; Belongs to the BI1 family. (331 aa)
LOC101066987Bcr-Abl_Oligo domain-containing protein. (1454 aa)
LOC101074026Mitogen-activated protein kinase. (364 aa)
LOC101062695Mitogen-activated protein kinase 12a. (361 aa)
LOC101074428Mitogen-activated protein kinase. (412 aa)
wap65-2Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (449 aa)
LOC105418743BCL2 associated agonist of cell death b. (168 aa)
LOC101064045Mitogen-activated protein kinase. (383 aa)
LOC101067723Cell division cycle 42. (191 aa)
LOC101067856Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (353 aa)
H2SH89_TAKRUPeptidase S1 domain-containing protein. (644 aa)
LOC101072985Uncharacterized protein. (606 aa)
rabifRAB interacting factor. (142 aa)
LOC101069822Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (384 aa)
TOLLIPToll-interacting protein. (275 aa)
map2k2Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (399 aa)
sos2Son of sevenless homolog 2 (Drosophila). (1336 aa)
LOC101078862Hepatocyte growth factor a; Belongs to the peptidase S1 family. Plasminogen subfamily. (717 aa)
c9Complement component C9; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC; Belongs to the complement C6/C7/C8/C9 family. (566 aa)
irf5IRF tryptophan pentad repeat domain-containing protein. (497 aa)
LOC101066292Uncharacterized protein; Belongs to the protein kinase superfamily. (372 aa)
btkTyrosine-protein kinase. (634 aa)
RASGRP1RAS guanyl releasing protein 1. (786 aa)
apaf1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1292 aa)
LOC101075779TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
LOC101066992Serine protease 59, tandem duplicate 1; Belongs to the peptidase S1 family. (251 aa)
itkTyrosine-protein kinase. (622 aa)
LOC101067067DED domain-containing protein. (196 aa)
LOC101061159Tetraspanin. (239 aa)
LOC105418528Uncharacterized protein. (1035 aa)
LOC101078355Toll interacting protein. (275 aa)
plcg11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1314 aa)
casp7Caspase 7, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (315 aa)
ptenPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (452 aa)
myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (288 aa)
irak4Interleukin-1 receptor-associated kinase 4. (460 aa)
il-18Takifugu rubripes interleukin-18 (il-18), mRNA. (185 aa)
tlr3Toll-like receptor 3. (913 aa)
LOC101077059Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (327 aa)
traf2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (520 aa)
meltfSerotransferrin; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate. (753 aa)
traddTnfrsf1a-associated via death domain. (305 aa)
casp9Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (432 aa)
plcg2Phosphoinositide phospholipase C. (1248 aa)
tirapToll-interleukin 1 receptor (TIR) domain containing adaptor protein. (180 aa)
LOC101061773Interleukin-1 receptor-associated kinase 1. (721 aa)
LOC101064444TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (597 aa)
traf3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (614 aa)
LOC101077601Serotransferrin; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate. (955 aa)
pak1Non-specific serine/threonine protein kinase. (562 aa)
LOC101072918Uncharacterized protein; Belongs to the peptidase S1 family. (665 aa)
tlr5TIR domain-containing protein; Belongs to the Toll-like receptor family. (884 aa)
lckTyrosine-protein kinase. (511 aa)
apo14kDaUncharacterized protein. (168 aa)
fynTyrosine-protein kinase. (538 aa)
tlr2Toll-like receptor 2. (810 aa)
LOC101075537Baculoviral IAP repeat containing 2. (639 aa)
LOC101067377Mitogen-activated protein kinase. (408 aa)
il1bInterleukin-1; Belongs to the IL-1 family. (256 aa)
LOC101065354Complement 4B (Chido blood group). (1703 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (280 aa)
bcrSi:dkey-91m11.5. (1287 aa)
LOC101076070Serotransferrin; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate. (720 aa)
hpxHemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (425 aa)
ticamToll-like receptor adaptor molecule. (577 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1313 aa)
LOC101064315Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (756 aa)
habp2Hyaluronan binding protein 2. (556 aa)
Il-18Interleukin-18. (185 aa)
LOC101071639Interferon regulatory factor 3. (465 aa)
prkcqProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
c3Uncharacterized protein. (1735 aa)
casp8Uncharacterized protein; Belongs to the peptidase C14A family. (526 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2554 aa)
casp6Caspase 6, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (303 aa)
grb2Growth factor receptor-bound protein 2b. (220 aa)
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.