(31 nodes) (2017) Novel transcriptome assembly and comparative toxicity pathway analysis in mahi-mahi (Coryphaena hippurus) embryos and larvae exposed to Deepwater Horizon oil. network (Takifugu rubripes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC777975	Noggin; Belongs to the noggin family. (210 aa)
	hmgcr	3-hydroxy-3-methylglutaryl coenzyme A reductase. (886 aa)
	fdft1	Farnesyl-diphosphate farnesyltransferase 1. (457 aa)
	tnnt2	Troponin T type 2a (cardiac). (299 aa)
	abcg5	ATP-binding cassette, sub-family G (WHITE), member 5. (643 aa)
	ahr2a	Uncharacterized protein. (929 aa)
	LOC101070433	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (427 aa)
	ahr1a	Uncharacterized protein. (975 aa)
	LOC101063574	Myosin light chain 4. (202 aa)
	abca1	ATP-binding cassette, sub-family A (ABC1), member 1A. (2282 aa)
	pik3ip1	Phosphoinositide-3-kinase interacting protein 1. (279 aa)
	msmo1	Methylsterol monooxygenase 1; Belongs to the sterol desaturase family. (361 aa)
	LOC101078757	3-hydroxy-3-methylglutaryl coenzyme A reductase. (862 aa)
	abcg8	ATP-binding cassette, sub-family G (WHITE), member 8. (659 aa)
	ahr1b	Aryl hydrocarbon receptor 1B. (854 aa)
	LOC101077970	Tight junction protein 2b (zona occludens 2); Belongs to the MAGUK family. (1150 aa)
	ahr2b	PAS domain-containing protein. (980 aa)
	LOC101068538	Fibroblast growth factor receptor 4. (1053 aa)
	LOC101074542	Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. (521 aa)
	cxcl14	Chemokine (C-X-C motif) ligand 14. (217 aa)
	bmp4	Bone morphogenetic protein 4. (459 aa)
	ahr2c	Uncharacterized protein. (818 aa)
	ppard	Uncharacterized protein. (491 aa)
	ENSTRUP00000084559	ATP-binding cassette, subfamily G (WHITE), member 1. (666 aa)
	fdps	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (373 aa)
	nppb	Brain natriuretic peptide; Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Has a cGMP-stimulating activity (By similarity); Belongs to the natriuretic peptide family. (275 aa)
	LOC101067723	Cell division cycle 42. (191 aa)
	LOC101061703	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (441 aa)
	LOC101065431	Potassium inwardly-rectifying channel, subfamily J, member 11. (384 aa)
	nog	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling. (250 aa)
	LOC101071896	7-dehydrocholesterol reductase. (472 aa)

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSTRUP00000084559	LOC101071896	ENSTRUP00000084559	ENSTRUP00000009273	ATP-binding cassette, subfamily G (WHITE), member 1.	7-dehydrocholesterol reductase.	0.417
ENSTRUP00000084559	LOC101078757	ENSTRUP00000084559	ENSTRUP00000074548	ATP-binding cassette, subfamily G (WHITE), member 1.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.475
ENSTRUP00000084559	abcg5	ENSTRUP00000084559	ENSTRUP00000023704	ATP-binding cassette, subfamily G (WHITE), member 1.	ATP-binding cassette, sub-family G (WHITE), member 5.	0.833
ENSTRUP00000084559	fdft1	ENSTRUP00000084559	ENSTRUP00000030934	ATP-binding cassette, subfamily G (WHITE), member 1.	Farnesyl-diphosphate farnesyltransferase 1.	0.452
ENSTRUP00000084559	fdps	ENSTRUP00000084559	ENSTRUP00000080593	ATP-binding cassette, subfamily G (WHITE), member 1.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.456
LOC101061703	LOC101063574	ENSTRUP00000076810	ENSTRUP00000016130	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Myosin light chain 4.	0.532
LOC101061703	LOC101065431	ENSTRUP00000076810	ENSTRUP00000017672	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Potassium inwardly-rectifying channel, subfamily J, member 11.	0.470
LOC101061703	LOC101070433	ENSTRUP00000076810	ENSTRUP00000076592	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.901
LOC101061703	LOC777975	ENSTRUP00000076810	ENSTRUP00000036627	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Noggin; Belongs to the noggin family.	0.451
LOC101061703	nog	ENSTRUP00000076810	ENSTRUP00000006286	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling.	0.435
LOC101061703	tnnt2	ENSTRUP00000076810	ENSTRUP00000029972	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Troponin T type 2a (cardiac).	0.529
LOC101063574	LOC101061703	ENSTRUP00000016130	ENSTRUP00000076810	Myosin light chain 4.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.532
LOC101063574	LOC101065431	ENSTRUP00000016130	ENSTRUP00000017672	Myosin light chain 4.	Potassium inwardly-rectifying channel, subfamily J, member 11.	0.443
LOC101063574	LOC101070433	ENSTRUP00000016130	ENSTRUP00000076592	Myosin light chain 4.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.532
LOC101063574	LOC777975	ENSTRUP00000016130	ENSTRUP00000036627	Myosin light chain 4.	Noggin; Belongs to the noggin family.	0.451
LOC101063574	nog	ENSTRUP00000016130	ENSTRUP00000006286	Myosin light chain 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling.	0.429
LOC101063574	tnnt2	ENSTRUP00000016130	ENSTRUP00000029972	Myosin light chain 4.	Troponin T type 2a (cardiac).	0.773
LOC101065431	LOC101061703	ENSTRUP00000017672	ENSTRUP00000076810	Potassium inwardly-rectifying channel, subfamily J, member 11.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.470
LOC101065431	LOC101063574	ENSTRUP00000017672	ENSTRUP00000016130	Potassium inwardly-rectifying channel, subfamily J, member 11.	Myosin light chain 4.	0.443
LOC101065431	LOC101070433	ENSTRUP00000017672	ENSTRUP00000076592	Potassium inwardly-rectifying channel, subfamily J, member 11.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.471