(14 nodes) (2017) Peptides, Peptidomimetics, and Polypeptides from Marine Sources: A Wealth of Natural Sources for Pharmaceutical Applications. network (Takifugu rubripes)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101063159	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (912 aa)
	hdac5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1134 aa)
	il1b	Interleukin-1; Belongs to the IL-1 family. (256 aa)
	ace	Angiotensin-converting enzyme. (1290 aa)
	LOC101077704	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1098 aa)
	nos1	Nitric oxide synthase; Produces nitric oxide (NO). (1428 aa)
	hdac4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1112 aa)
	LOC105418820	Insulin. (114 aa)
	LOC101074356	Zgc:112160; Belongs to the peptidase S1 family. (264 aa)
	LOC101074083	Tyrosine-protein kinase receptor. (1393 aa)
	LOC101061705	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1006 aa)
	ace2	Angiotensin-converting enzyme. (818 aa)
	LOC101074582	Zgc:136461; Belongs to the peptidase S1 family. (263 aa)
	LOC101077681	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (264 aa)

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101074083	LOC105418820	ENSTRUP00000074370	ENSTRUP00000071470	Tyrosine-protein kinase receptor.	Insulin.	0.776
LOC101077704	hdac4	ENSTRUP00000059304	ENSTRUP00000065796	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.901
LOC101077704	hdac5	ENSTRUP00000059304	ENSTRUP00000030069	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.903
LOC105418820	LOC101074083	ENSTRUP00000071470	ENSTRUP00000074370	Insulin.	Tyrosine-protein kinase receptor.	0.776
LOC105418820	ace	ENSTRUP00000071470	ENSTRUP00000042104	Insulin.	Angiotensin-converting enzyme.	0.453
LOC105418820	il1b	ENSTRUP00000071470	ENSTRUP00000040920	Insulin.	Interleukin-1; Belongs to the IL-1 family.	0.417
ace	LOC105418820	ENSTRUP00000042104	ENSTRUP00000071470	Angiotensin-converting enzyme.	Insulin.	0.453
ace	ace2	ENSTRUP00000042104	ENSTRUP00000080132	Angiotensin-converting enzyme.	Angiotensin-converting enzyme.	0.418
ace2	ace	ENSTRUP00000080132	ENSTRUP00000042104	Angiotensin-converting enzyme.	Angiotensin-converting enzyme.	0.418
hdac4	LOC101077704	ENSTRUP00000065796	ENSTRUP00000059304	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.901
hdac4	hdac5	ENSTRUP00000065796	ENSTRUP00000030069	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.903
hdac5	LOC101077704	ENSTRUP00000030069	ENSTRUP00000059304	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.903
hdac5	hdac4	ENSTRUP00000030069	ENSTRUP00000065796	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.903
il1b	LOC105418820	ENSTRUP00000040920	ENSTRUP00000071470	Interleukin-1; Belongs to the IL-1 family.	Insulin.	0.417
il1b	nos1	ENSTRUP00000040920	ENSTRUP00000059857	Interleukin-1; Belongs to the IL-1 family.	Nitric oxide synthase; Produces nitric oxide (NO).	0.436
nos1	il1b	ENSTRUP00000059857	ENSTRUP00000040920	Nitric oxide synthase; Produces nitric oxide (NO).	Interleukin-1; Belongs to the IL-1 family.	0.436