10 items (Takifugu rubripes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (477 aa)
	ENSTRUP00000058317	Polyubiquitin-like. (110 aa)
	traf4	TNF receptor-associated factor. (470 aa)
	nck1	Cytoplasmic protein. (399 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
	il1b	Interleukin-1; Belongs to the IL-1 family. (256 aa)
	nck2	Cytoplasmic protein. (396 aa)
	traf7	TNF receptor-associated factor 7. (661 aa)
	LOC101079595	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (391 aa)
	nod2	CARD15. (998 aa)

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSTRUP00000058317	LOC101079595	ENSTRUP00000058317	ENSTRUP00000030644	Polyubiquitin-like.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.423
ENSTRUP00000058317	il1b	ENSTRUP00000058317	ENSTRUP00000040920	Polyubiquitin-like.	Interleukin-1; Belongs to the IL-1 family.	0.433
ENSTRUP00000058317	traf4	ENSTRUP00000058317	ENSTRUP00000056400	Polyubiquitin-like.	TNF receptor-associated factor.	0.480
ENSTRUP00000058317	traf6	ENSTRUP00000058317	ENSTRUP00000041697	Polyubiquitin-like.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.683
ENSTRUP00000058317	traf7	ENSTRUP00000058317	ENSTRUP00000034084	Polyubiquitin-like.	TNF receptor-associated factor 7.	0.906
LOC101079595	ENSTRUP00000058317	ENSTRUP00000030644	ENSTRUP00000058317	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Polyubiquitin-like.	0.423
LOC101079595	akt1	ENSTRUP00000030644	ENSTRUP00000084921	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.480
LOC101079595	traf6	ENSTRUP00000030644	ENSTRUP00000041697	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.608
LOC101079595	traf7	ENSTRUP00000030644	ENSTRUP00000034084	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	TNF receptor-associated factor 7.	0.475
akt1	LOC101079595	ENSTRUP00000084921	ENSTRUP00000030644	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.480
akt1	nck1	ENSTRUP00000084921	ENSTRUP00000045455	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cytoplasmic protein.	0.472
akt1	nck2	ENSTRUP00000084921	ENSTRUP00000034543	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cytoplasmic protein.	0.472
akt1	traf4	ENSTRUP00000084921	ENSTRUP00000056400	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	TNF receptor-associated factor.	0.419
akt1	traf6	ENSTRUP00000084921	ENSTRUP00000041697	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.492
akt1	traf7	ENSTRUP00000084921	ENSTRUP00000034084	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	TNF receptor-associated factor 7.	0.607
il1b	ENSTRUP00000058317	ENSTRUP00000040920	ENSTRUP00000058317	Interleukin-1; Belongs to the IL-1 family.	Polyubiquitin-like.	0.433
il1b	nod2	ENSTRUP00000040920	ENSTRUP00000067959	Interleukin-1; Belongs to the IL-1 family.	CARD15.	0.475
il1b	traf6	ENSTRUP00000040920	ENSTRUP00000041697	Interleukin-1; Belongs to the IL-1 family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.867
il1b	traf7	ENSTRUP00000040920	ENSTRUP00000034084	Interleukin-1; Belongs to the IL-1 family.	TNF receptor-associated factor 7.	0.402
nck1	akt1	ENSTRUP00000045455	ENSTRUP00000084921	Cytoplasmic protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.472