STRINGSTRING
LOC101063185 LOC101063185 LOC101066871 LOC101066871 cdc27 cdc27 LOC101076451 LOC101076451 LOC101073562 LOC101073562 LOC101077745 LOC101077745 ttk ttk LOC101064374 LOC101064374 LOC101078750 LOC101078750 LOC101070983 LOC101070983 LOC101071662 LOC101071662 anapc2 anapc2 cdkn2d cdkn2d orc1 orc1 rbl1 rbl1 orc3 orc3 smc3 smc3 rad21 rad21 mcm2 mcm2 ccne2 ccne2 skp1 skp1 mdm2 mdm2 myc myc cdc14a cdc14a LOC101063905 LOC101063905 LOC101077955 LOC101077955 wee1 wee1 e2f4 e2f4 bub3 bub3 LOC101072042 LOC101072042 LOC101080220 LOC101080220 YWHAB YWHAB e2f1 e2f1 ccnb1 ccnb1 e2f2 e2f2 LOC101079595 LOC101079595 LOC101070901 LOC101070901 GADD45B GADD45B LOC101077171 LOC101077171 LOC101073984 LOC101073984 tfdp1 tfdp1 LOC101074584 LOC101074584 LOC101067307 LOC101067307 stag1 stag1 ywhaq ywhaq atr atr chek2 chek2 smc1a smc1a anapc4 anapc4 bub1 bub1 cdk6 cdk6 mad1l1 mad1l1 LOC101068040 LOC101068040 orc5 orc5 ccnd1 ccnd1 LOC115246431 LOC115246431 tgf-beta1 tgf-beta1 LOC101069671 LOC101069671 anapc5 anapc5 cdc45 cdc45 chek1 chek1 prkdc prkdc anapc10 anapc10 cdc16 cdc16 SMAD4 SMAD4 LOC101072182 LOC101072182 E2F3 E2F3 ccnh ccnh LOC101074416 LOC101074416 bub1b bub1b ENSTRUP00000049720 ENSTRUP00000049720 ENSTRUP00000050866 ENSTRUP00000050866 tgfb3 tgfb3 LOC101066787 LOC101066787 pcna pcna LOC101068466 LOC101068466 cdkn1b cdkn1b LOC101076205 LOC101076205 LOC101079162 LOC101079162 orc4 orc4 pkmyt1 pkmyt1 LOC101063623 LOC101063623 LOC101077048 LOC101077048 FZR1 FZR1 mcm5 mcm5 LOC101079903 LOC101079903 GADD45B-2 GADD45B-2 espl1 espl1 mcm3 mcm3 ccna1 ccna1 LOC105417819 LOC105417819 LOC101065671 LOC101065671 abl1 abl1 LOC115248454 LOC115248454 orc2 orc2 anapc11 anapc11 anapc7 anapc7 LOC101065632 LOC101065632 YWHAE YWHAE anapc13 anapc13 HDAC2 HDAC2 LOC115248448 LOC115248448 ENSTRUP00000069966 ENSTRUP00000069966 LOC101079814 LOC101079814 LOC101072742 LOC101072742 cdk4 cdk4 LOC101072871 LOC101072871 mad2l1 mad2l1 ywhaz ywhaz LOC101077875 LOC101077875 gadd45a gadd45a cdk2 cdk2 LOC101076947 LOC101076947 zbtb17 zbtb17 gsk3b gsk3b LOC101078653 LOC101078653 LOC101069155 LOC101069155 LOC115251941 LOC115251941 mcm7 mcm7 cdc6 cdc6 cdc25b cdc25b mcm6 mcm6 cdkn2A/B cdkn2A/B mcm4 mcm4 LOC101077647 LOC101077647 atm atm
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC101063185Uncharacterized protein; Belongs to the cyclin family. (380 aa)
LOC101066871Cyclin Dx; Belongs to the cyclin family. (300 aa)
cdc27Cell division cycle 27. (839 aa)
LOC101076451Fizzy/cell division cycle 20 related 1b. (487 aa)
LOC101073562Cyclin D2, a; Belongs to the cyclin family. (296 aa)
LOC101077745E2F transcription factor 5. (362 aa)
ttkTtk protein kinase. (1022 aa)
LOC101064374Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (301 aa)
LOC101078750RAD21 cohesin complex component like 1. (562 aa)
LOC101070983Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; Belongs to the 14-3-3 family. (248 aa)
LOC101071662Wee1-like protein kinase. (557 aa)
anapc2Anaphase promoting complex subunit 2; Belongs to the cullin family. (817 aa)
cdkn2dCyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). (164 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (898 aa)
rbl1Retinoblastoma-like 1 (p107). (1045 aa)
orc3Origin recognition complex, subunit 3. (716 aa)
smc3Structural maintenance of chromosomes protein. (1162 aa)
rad21RAD21 cohesin complex component a. (635 aa)
mcm2DNA helicase; Belongs to the MCM family. (896 aa)
ccne2Cyclin E2; Belongs to the cyclin family. (416 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
mdm2MDM2 proto-oncogene. (495 aa)
mycTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (418 aa)
cdc14aCell division cycle 14Ab. (609 aa)
LOC101063905Cyclin D3; Belongs to the cyclin family. (300 aa)
LOC101077955Transforming growth factor beta; Belongs to the TGF-beta family. (406 aa)
wee1Wee1-like protein kinase. (645 aa)
e2f4E2F transcription factor 4. (387 aa)
bub3BUB3 mitotic checkpoint protein. (339 aa)
LOC101072042Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (476 aa)
LOC101080220Cyclin D2, b; Belongs to the cyclin family. (294 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b; Belongs to the 14-3-3 family. (244 aa)
e2f1E2F transcription factor 1. (452 aa)
ccnb1Cyclin B1; Belongs to the cyclin family. (403 aa)
e2f2Si:ch211-160f23.5. (440 aa)
LOC101079595Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (391 aa)
LOC101070901Retinoblastoma-like 2 (p130). (1084 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (173 aa)
LOC101077171Growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1. (154 aa)
LOC101073984CREB binding protein a. (3609 aa)
tfdp1Transcription factor. (412 aa)
LOC101074584Transforming growth factor beta; Belongs to the TGF-beta family. (420 aa)
LOC101067307Si:ch211-269e2.1. (1178 aa)
stag1Stromal antigen 1a. (1260 aa)
ywhaq14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (249 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2599 aa)
chek2Checkpoint kinase 2. (538 aa)
smc1aStructural maintenance of chromosomes protein. (1232 aa)
anapc4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (813 aa)
bub1BUB1 mitotic checkpoint serine/threonine kinase. (1153 aa)
cdk6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (325 aa)
mad1l1Mitotic arrest deficient 1 like 1. (719 aa)
LOC101068040Uncharacterized protein. (669 aa)
orc5Origin recognition complex, subunit 5. (460 aa)
ccnd1Cyclin D1. (292 aa)
LOC115246431Retinoblastoma 1. (913 aa)
tgf-beta1Transforming growth factor beta; Belongs to the TGF-beta family. (383 aa)
LOC101069671Cyclin-dependent kinase inhibitor 1Cb. (214 aa)
anapc5Anaphase promoting complex subunit 5. (770 aa)
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae). (568 aa)
chek1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa)
prkdcProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4112 aa)
anapc10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (182 aa)
cdc16Cell division cycle 16 homolog (S. cerevisiae). (620 aa)
SMAD4Mothers against decapentaplegic homolog. (521 aa)
LOC101072182Uncharacterized protein. (178 aa)
E2F3E2F transcription factor 3. (439 aa)
ccnhCyclin H; Belongs to the cyclin family. (319 aa)
LOC101074416Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (391 aa)
bub1bBUB1 mitotic checkpoint serine/threonine kinase Bb. (403 aa)
ENSTRUP00000049720E2F_TDP domain-containing protein. (82 aa)
ENSTRUP00000050866Uncharacterized protein. (177 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (404 aa)
LOC101066787Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
LOC101068466Mothers against decapentaplegic homolog 4-like. (557 aa)
cdkn1bCyclin-dependent kinase inhibitor 1Bb. (184 aa)
LOC101076205Cyclin B2; Belongs to the cyclin family. (416 aa)
LOC101079162Cyclin-dependent kinase inhibitor 1D. (181 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (538 aa)
pkmyt1Protein kinase, membrane associated tyrosine/threonine 1. (588 aa)
LOC10106362314_3_3 domain-containing protein. (245 aa)
LOC101077048Stromal antigen 2b. (1274 aa)
FZR1Fizzy/cell division cycle 20 related 1a. (496 aa)
mcm5DNA helicase; Belongs to the MCM family. (737 aa)
LOC1010799033-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2; Belongs to the 14-3-3 family. (247 aa)
GADD45B-2Growth arrest and DNA damage inducible beta. (164 aa)
espl1Extra spindle pole bodies like 1, separase. (1956 aa)
mcm3DNA helicase; Belongs to the MCM family. (813 aa)
ccna1Cyclin-A1 isoform X1. (414 aa)
LOC105417819Cyclin-dependent kinase inhibitor 1A. (205 aa)
LOC101065671Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (385 aa)
abl1Tyrosine-protein kinase. (1115 aa)
LOC115248454RING-box protein 1. (126 aa)
orc2Origin recognition complex, subunit 2. (601 aa)
anapc11APC11 anaphase promoting complex subunit 11 homolog (yeast). (84 aa)
anapc7Anaphase promoting complex subunit 7. (567 aa)
LOC101065632G1/S-specific cyclin-E1-like isoform X1. (502 aa)
YWHAE14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)
anapc13Anaphase promoting complex subunit 13. (74 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (489 aa)
LOC115248448E1A binding protein p300 b. (2795 aa)
ENSTRUP00000069966Cyclin-dependent kinase 6-like isoform X2. (309 aa)
LOC101079814Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
LOC101072742Myelocytomatosis oncogene homolog. (367 aa)
cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (299 aa)
LOC101072871Mothers against decapentaplegic homolog. (467 aa)
mad2l1MAD2 mitotic arrest deficient-like 1 (yeast). (202 aa)
ywhaz14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (241 aa)
LOC101077875Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family. (257 aa)
gadd45aGrowth arrest and DNA-damage-inducible, alpha, a. (162 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
LOC101076947Growth arrest and DNA damage-inducible protein GADD45 gamma-like. (163 aa)
zbtb17Zinc finger and BTB domain-containing protein 17 isoform X1. (883 aa)
gsk3bGlycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (459 aa)
LOC1010786533-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1; Belongs to the 14-3-3 family. (247 aa)
LOC101069155Stromal antigen 2a. (1278 aa)
LOC115251941Cyclin E1; Belongs to the cyclin family. (502 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (732 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (574 aa)
cdc25bCell division cycle 25B. (606 aa)
mcm6DNA helicase; Belongs to the MCM family. (826 aa)
cdkn2A/BCyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (133 aa)
mcm4DNA helicase; Belongs to the MCM family. (869 aa)
LOC101077647E2F_TDP domain-containing protein. (84 aa)
atmTAN domain-containing protein. (3087 aa)
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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